Transcript
m o l e c u l a r
s p e c t r o s c o p y
DXR Raman Microscope
Precision Raman Microscopy Point-and-shoot Raman microscopy Exceptional spatial resolution Powerful analytical tool focused on results Three excitation laser frequencies
Part of Thermo Fisher Scientific
F O C U S O N R E S U LT S – DXR R A M A N M I C R O S C O P E
Packaging
Forensics
Fibers
Gems/Geology
Art Restoration
The DXR Raman microscope delivers uncompromising 1-micron spatial resolution and true confocal depth profiling for the most demanding analytical challenges.
Nanotechnology
DXR Micro Interior 1-23-08
1/23/08
7:43 PM
Page 2
ANSWERS YOU CAN TRUST
Patent g Pendin
T HE R AMAN M ICROSCOPE D ESIGNED W ITH Y OU I N M IND
Results Made Easy
From the Experts in Raman Microscopy
The DXR Raman microscope lets the user focus on the results, not on learning new techniques and procedures. At Thermo Scientific, we design instruments that take care of the details.
With many years of experience in Raman and FT-IR microscopy, Thermo Fisher Scientific has designed the DXR Raman microscope to encompass all the benefits of Raman microscopy in one simple, easy-to-use instrument. The DXR Raman microscope includes patented technology to take the guesswork out of achieving optimal performance – routinely and reproducibly. This is the Raman microscope that the busy analytical lab cannot afford to be without.
Top Quality Results Made Easy – unique software features optimize signal-to-noise to reveal even the finest details in a spectrum of Tyrian Purple pigment.
Your Applications and Raman Microscopy You are going to find yourself relying on your DXR Raman microscope for many of your most challenging applications. For small particle analysis, the 1-micron spatial resolution is invaluable. In addition, the DXR Raman microscope gives you true confocal depth profiling abilities, enabling you to look for evidence of inclusions or impurities and characterize multi-layer polymer films. Raman provides many benefits:
Autofocus – optimizes the focus to maximize the Raman signal automatically. Smart Background – the DXR Raman microscope collects background data during instrument downtime, so that the user never has to wait.
• Rapid and non destructive • No sample preparation • No water interference – easy to measure aqueous samples • Complementary to FT-IR • Easy access to low vibrational frequencies, making it easy to analyze inorganic molecules
Automatic Fluorescence Correction – automatically corrects for fluorescence interference. Available for all excitation lasers.
Laser Power Regulator – compensates for changes in laser power output and guarantees consistent Raman response. Legend: Zone A: The Laser Power Regulator controls the laser power reaching the sample to ensure reproducible results. Zone B: As the laser power declines over its lifetime, measurements become non-reproducible on instruments lacking a Laser Power Regulator. Zone C: Beyond the expected laser lifetime. The DXR Raman microscope can still be used reproducibly at lower power levels, however the laser should be replaced in order to obtain maximum power output.
Automatic Intensity Correction – compensates for detector wavelength dependence.
• Dyes and Chemicals • Fibers • Pharmaceuticals • Nanotechnology • Packaging • Polymers • Paper Manufacturing • Forensics • Gemstones • Geology • Art Restoration and the Study of Cultural Artifacts
Raman microscopy is employed at many stages in the manufacturing process from research to final product QC: • Methods Development •R&D • QA/QC • Reverse Engineering • Failure and Defect Analysis
The DXR Raman Microscope The DXR Raman microscope is a research-quality tool designed specifically for today’s multi-purpose analytical labs. This is the microscope for the user who needs the high spatial resolution, ease of sample preparation and power of Raman microscopy, and who has neither the time nor the desire to become a Raman expert. The DXR Raman microscope delivers spatial resolution that is as good or better than any instrument on the market, together with unique features designed to make it as easy as possible to get high quality results.
Autoexposure – the DXR Raman microscope calculates the exposure time and number of exposures for optimal sensitivity.
Raman microscopy is of critical value in industrial and non-industrial environments alike. New applications are being discovered daily in:
• Patented autoalignment system for guaranteed optimal performance • True point-and-shoot Raman capability • Exceptional spatial resolution • Superb visual quality
Unlock the power of Raman microscopy, effortlessly…
DXR Micro Interior 1-23-08
1/23/08
7:43 PM
Page 2
ANSWERS YOU CAN TRUST
Patent g Pendin
T HE R AMAN M ICROSCOPE D ESIGNED W ITH Y OU I N M IND
Results Made Easy
From the Experts in Raman Microscopy
The DXR Raman microscope lets the user focus on the results, not on learning new techniques and procedures. At Thermo Scientific, we design instruments that take care of the details.
With many years of experience in Raman and FT-IR microscopy, Thermo Fisher Scientific has designed the DXR Raman microscope to encompass all the benefits of Raman microscopy in one simple, easy-to-use instrument. The DXR Raman microscope includes patented technology to take the guesswork out of achieving optimal performance – routinely and reproducibly. This is the Raman microscope that the busy analytical lab cannot afford to be without.
Top Quality Results Made Easy – unique software features optimize signal-to-noise to reveal even the finest details in a spectrum of Tyrian Purple pigment.
Your Applications and Raman Microscopy You are going to find yourself relying on your DXR Raman microscope for many of your most challenging applications. For small particle analysis, the 1-micron spatial resolution is invaluable. In addition, the DXR Raman microscope gives you true confocal depth profiling abilities, enabling you to look for evidence of inclusions or impurities and characterize multi-layer polymer films. Raman provides many benefits:
Autofocus – optimizes the focus to maximize the Raman signal automatically. Smart Background – the DXR Raman microscope collects background data during instrument downtime, so that the user never has to wait.
• Rapid and non destructive • No sample preparation • No water interference – easy to measure aqueous samples • Complementary to FT-IR • Easy access to low vibrational frequencies, making it easy to analyze inorganic molecules
Automatic Fluorescence Correction – automatically corrects for fluorescence interference. Available for all excitation lasers.
Laser Power Regulator – compensates for changes in laser power output and guarantees consistent Raman response. Legend: Zone A: The Laser Power Regulator controls the laser power reaching the sample to ensure reproducible results. Zone B: As the laser power declines over its lifetime, measurements become non-reproducible on instruments lacking a Laser Power Regulator. Zone C: Beyond the expected laser lifetime. The DXR Raman microscope can still be used reproducibly at lower power levels, however the laser should be replaced in order to obtain maximum power output.
Automatic Intensity Correction – compensates for detector wavelength dependence.
• Dyes and Chemicals • Fibers • Pharmaceuticals • Nanotechnology • Packaging • Polymers • Paper Manufacturing • Forensics • Gemstones • Geology • Art Restoration and the Study of Cultural Artifacts
Raman microscopy is employed at many stages in the manufacturing process from research to final product QC: • Methods Development •R&D • QA/QC • Reverse Engineering • Failure and Defect Analysis
The DXR Raman Microscope The DXR Raman microscope is a research-quality tool designed specifically for today’s multi-purpose analytical labs. This is the microscope for the user who needs the high spatial resolution, ease of sample preparation and power of Raman microscopy, and who has neither the time nor the desire to become a Raman expert. The DXR Raman microscope delivers spatial resolution that is as good or better than any instrument on the market, together with unique features designed to make it as easy as possible to get high quality results.
Autoexposure – the DXR Raman microscope calculates the exposure time and number of exposures for optimal sensitivity.
Raman microscopy is of critical value in industrial and non-industrial environments alike. New applications are being discovered daily in:
• Patented autoalignment system for guaranteed optimal performance • True point-and-shoot Raman capability • Exceptional spatial resolution • Superb visual quality
Unlock the power of Raman microscopy, effortlessly…
DXR Micro Interior 1-23-08
1/23/08
7:43 PM
Page 2
ANSWERS YOU CAN TRUST
Patent g Pendin
T HE R AMAN M ICROSCOPE D ESIGNED W ITH Y OU I N M IND
Results Made Easy
From the Experts in Raman Microscopy
The DXR Raman microscope lets the user focus on the results, not on learning new techniques and procedures. At Thermo Scientific, we design instruments that take care of the details.
With many years of experience in Raman and FT-IR microscopy, Thermo Fisher Scientific has designed the DXR Raman microscope to encompass all the benefits of Raman microscopy in one simple, easy-to-use instrument. The DXR Raman microscope includes patented technology to take the guesswork out of achieving optimal performance – routinely and reproducibly. This is the Raman microscope that the busy analytical lab cannot afford to be without.
Top Quality Results Made Easy – unique software features optimize signal-to-noise to reveal even the finest details in a spectrum of Tyrian Purple pigment.
Your Applications and Raman Microscopy You are going to find yourself relying on your DXR Raman microscope for many of your most challenging applications. For small particle analysis, the 1-micron spatial resolution is invaluable. In addition, the DXR Raman microscope gives you true confocal depth profiling abilities, enabling you to look for evidence of inclusions or impurities and characterize multi-layer polymer films. Raman provides many benefits:
Autofocus – optimizes the focus to maximize the Raman signal automatically. Smart Background – the DXR Raman microscope collects background data during instrument downtime, so that the user never has to wait.
• Rapid and non destructive • No sample preparation • No water interference – easy to measure aqueous samples • Complementary to FT-IR • Easy access to low vibrational frequencies, making it easy to analyze inorganic molecules
Automatic Fluorescence Correction – automatically corrects for fluorescence interference. Available for all excitation lasers.
Laser Power Regulator – compensates for changes in laser power output and guarantees consistent Raman response. Legend: Zone A: The Laser Power Regulator controls the laser power reaching the sample to ensure reproducible results. Zone B: As the laser power declines over its lifetime, measurements become non-reproducible on instruments lacking a Laser Power Regulator. Zone C: Beyond the expected laser lifetime. The DXR Raman microscope can still be used reproducibly at lower power levels, however the laser should be replaced in order to obtain maximum power output.
Automatic Intensity Correction – compensates for detector wavelength dependence.
• Dyes and Chemicals • Fibers • Pharmaceuticals • Nanotechnology • Packaging • Polymers • Paper Manufacturing • Forensics • Gemstones • Geology • Art Restoration and the Study of Cultural Artifacts
Raman microscopy is employed at many stages in the manufacturing process from research to final product QC: • Methods Development •R&D • QA/QC • Reverse Engineering • Failure and Defect Analysis
The DXR Raman Microscope The DXR Raman microscope is a research-quality tool designed specifically for today’s multi-purpose analytical labs. This is the microscope for the user who needs the high spatial resolution, ease of sample preparation and power of Raman microscopy, and who has neither the time nor the desire to become a Raman expert. The DXR Raman microscope delivers spatial resolution that is as good or better than any instrument on the market, together with unique features designed to make it as easy as possible to get high quality results.
Autoexposure – the DXR Raman microscope calculates the exposure time and number of exposures for optimal sensitivity.
Raman microscopy is of critical value in industrial and non-industrial environments alike. New applications are being discovered daily in:
• Patented autoalignment system for guaranteed optimal performance • True point-and-shoot Raman capability • Exceptional spatial resolution • Superb visual quality
Unlock the power of Raman microscopy, effortlessly…
DXR Micro Interior 1-23-08
1/23/08
7:43 PM
Page 1
S I M P LY T H E B E S T
PERFORMANCE WITHOUT COMPROMISE
Raman Spectrometer
The Performance You Need
Invaluable – Now and into the Future
Effortless Maintenance
• Class I laser safe; safe to use in the open lab (Class IIIb optional)
The DXR Raman microscope is designed from start to finish as a robust analytical tool. This means no compromises on the performance features that matter.
The DXR Raman microscope is the platform that expands to meet your changing needs.
A fully calibrated and aligned instrument delivers reproducible results dependably. With its deceptively simple design and minimal moving parts, the DXR Raman microscope is easy to maintain. Patented autoalignment, calibration and other features make it easy to incorporate routine instrument maintenance into standard lab operating procedures.
• Convenient storage container for additional lasers, gratings and filters
Precision
a
b
Low Brightness
High Brightness
High Brightness Lasers – focus all of the laser energy on the target for better contrast and no wasted laser power. The absence of scatter from material surrounding the target guarantees true confocality.
Fiber optics for remote sampling
Visual Light Path
on ati cit x E
Patented Autoalignment – precision sampling with minimum interference from surrounding materials.
• High-resolution gratings for difficult to resolve bands. 50 cm-1 to 1800 cm-1 (fingerprint region) • SmartLock technology for reproducibly mounting lasers, gratings, filters, fiber port • Smart components report identity and serial numbers for compatibility checking, traceability and laser lifetime tracking • Patented Autoalignment procedure to ensure optimal alignment and precision sampling • Rapid automated calibration to ensure validity of results • Laser Power Regulator * Spectral range for the 780 nm excitation laser is 50 cm-1 to 3300 cm-1
Sampling Easy-to-maintain Spectrograph – no moving parts, unique design optimizes performance at all wavelengths.
• Software-controlled motorized microscope stage for automated data collection and sample mapping (manual stage optional) • Multi-well adapter for automated multi-well plate sampling • Spacious microscope stage compartment for large samples, heated, cooled and other specialty stages User-replaceable Components – no service calls required to replace a laser.
Add objectives for additional versatility
r se La
• Full range gratings for complete spectra in one shot. 50 cm-1 to 3500 cm-1, 5 cm-1 spectral resolution*
Pre-aligned Smart Components – factory-aligned components permit lasers, gratings and filters to be exchanged easily. Lasers, gratings, filters, fiber launcher identify themselves by serial number and wavelength. OMNIC software checks for component compatibility.
Exceptional Spatial Resolution – analyze the smallest sample features with confidence. (a) and (b): SEM of spatial resolution target and Raman map, respectively; (c) cross-section of the Raman map, demonstrating better than 1-micron resolution.
Ra ma n Sc att er
• Spectrometer with no moving parts for dependable performance
DIC and fluorescence for greater flexibility in sample imaging
Choice of Spectral Resolution – choose standard spectral resolution for routine analysis. For hard-toresolve bands high resolution gratings are available for all three lasers.
c
• 532-, 633- and 780-nm high-brightness lasers; factory aligned, user-interchangeable
Fully Automated Confocal Microscopy – 2-micron resolution for depth profiling and inclusion analysis. Depth profile of food packaging.
Superior Visual Imaging
• Trinocular • Full range of Olympus microscope options
Switch to brightfield or darkfield illumination
Multiple Lasers – Be ready for any sample. Expand the capabilities of the DXR Raman microscope by adding a second or third excitation laser. Minimize fluorescence interference, or enhance sensitivity by up to 10-fold. Facilities with more than one DXR microscope or SmartRaman can share lasers, gratings and filters between instruments for even greater versatility. Components are automatically recognized by Smart technology and pre-aligned so there is no need for a service call.
Smart Lasers – automatically track laser lifetime. Patented Autoalignment – keeps the excitation laser, the Raman scattering, and the visual light paths precisely aligned to the same sampling point for maximum sampling precision. No manual alignment necessary.
• Optional tube and vial sampling accessory • Fiber optic probe sampling option
Software • Comprehensive OMNIC software suite for full instrument control and data processing • OMNIC Array Automation provides automated data collection from sample arrays and post-collection data processing • OMNIC Atlµs™ software permits sample mapping and image analysis • TQ Analyst™ with chemometrics for comprehensive data analysis • Extensive Raman libraries and easy to use search capabilities
Light Microscope • Research grade microscope • 4X, 10X, 20X, 50X and 100X microscope objectives, with brightfield/darkfield, oil immersion, and long working distance options • Standard and brightfield/darkfield illuminators • Fluorescence and DIC light microscopy options
SmartLock Technology for Reproducible Results
• Digital video camera for video data capture • Trinocular for visual and video imaging (binocular or video only optional) SmartLock Filters
Users can configure the DXR Raman microscope with up to three different excitation wavelengths – at 532, 633 and 780 nm. The lasers, together with the appropriate filters and gratings, lock into place using SmartLock technology for precisely reproducible results. OMNIC™ software recognizes each component, records the serial numbers and checks for compatibility. A convenient storage container is provided for when the components are not in use.
SmartLock Grating
Ensures reproducible spectra even with multiple grating exchanges (plot shows an overlay of 150 spectra; grating exchanged between each collect).
Maintenance • Single beam-path spectrometer for robustness and simple alignment
Single USB Connection – full instrument control from either a desktop or laptop computer through a single USB port.
• Spectrograph with no moving parts for high reliability • Minimal service requirements
Automated Calibration – spectrograph, laser and Raman intensity calibrations are completely automated by OMNIC software using standards located in the alignment/calibration tool. SmartLock Lasers
Fine-adjust Mirrors – software-controlled mirror adjustments to maintain peak performance.
Laser Power Regulator – compensates for changes in laser power output and guarantees consistent power at the sample.
• All consumables, including lasers, are user-replaceable • Software-controlled alignment and calibration performed routinely by the user
Validation • ValPro™ System Qualification package for full validation to meet all regulatory requirements
DXR Micro Interior 1-23-08
1/23/08
7:43 PM
Page 1
S I M P LY T H E B E S T
PERFORMANCE WITHOUT COMPROMISE
Raman Spectrometer
The Performance You Need
Invaluable – Now and into the Future
Effortless Maintenance
• Class I laser safe; safe to use in the open lab (Class IIIb optional)
The DXR Raman microscope is designed from start to finish as a robust analytical tool. This means no compromises on the performance features that matter.
The DXR Raman microscope is the platform that expands to meet your changing needs.
A fully calibrated and aligned instrument delivers reproducible results dependably. With its deceptively simple design and minimal moving parts, the DXR Raman microscope is easy to maintain. Patented autoalignment, calibration and other features make it easy to incorporate routine instrument maintenance into standard lab operating procedures.
• Convenient storage container for additional lasers, gratings and filters
Precision
a
b
Low Brightness
High Brightness
High Brightness Lasers – focus all of the laser energy on the target for better contrast and no wasted laser power. The absence of scatter from material surrounding the target guarantees true confocality.
Fiber optics for remote sampling
Visual Light Path
on ati cit x E
Patented Autoalignment – precision sampling with minimum interference from surrounding materials.
• High-resolution gratings for difficult to resolve bands. 50 cm-1 to 1800 cm-1 (fingerprint region) • SmartLock technology for reproducibly mounting lasers, gratings, filters, fiber port • Smart components report identity and serial numbers for compatibility checking, traceability and laser lifetime tracking • Patented Autoalignment procedure to ensure optimal alignment and precision sampling • Rapid automated calibration to ensure validity of results • Laser Power Regulator * Spectral range for the 780 nm excitation laser is 50 cm-1 to 3300 cm-1
Sampling Easy-to-maintain Spectrograph – no moving parts, unique design optimizes performance at all wavelengths.
• Software-controlled motorized microscope stage for automated data collection and sample mapping (manual stage optional) • Multi-well adapter for automated multi-well plate sampling • Spacious microscope stage compartment for large samples, heated, cooled and other specialty stages User-replaceable Components – no service calls required to replace a laser.
Add objectives for additional versatility
r se La
• Full range gratings for complete spectra in one shot. 50 cm-1 to 3500 cm-1, 5 cm-1 spectral resolution*
Pre-aligned Smart Components – factory-aligned components permit lasers, gratings and filters to be exchanged easily. Lasers, gratings, filters, fiber launcher identify themselves by serial number and wavelength. OMNIC software checks for component compatibility.
Exceptional Spatial Resolution – analyze the smallest sample features with confidence. (a) and (b): SEM of spatial resolution target and Raman map, respectively; (c) cross-section of the Raman map, demonstrating better than 1-micron resolution.
Ra ma n Sc att er
• Spectrometer with no moving parts for dependable performance
DIC and fluorescence for greater flexibility in sample imaging
Choice of Spectral Resolution – choose standard spectral resolution for routine analysis. For hard-toresolve bands high resolution gratings are available for all three lasers.
c
• 532-, 633- and 780-nm high-brightness lasers; factory aligned, user-interchangeable
Fully Automated Confocal Microscopy – 2-micron resolution for depth profiling and inclusion analysis. Depth profile of food packaging.
Superior Visual Imaging
• Trinocular • Full range of Olympus microscope options
Switch to brightfield or darkfield illumination
Multiple Lasers – Be ready for any sample. Expand the capabilities of the DXR Raman microscope by adding a second or third excitation laser. Minimize fluorescence interference, or enhance sensitivity by up to 10-fold. Facilities with more than one DXR microscope or SmartRaman can share lasers, gratings and filters between instruments for even greater versatility. Components are automatically recognized by Smart technology and pre-aligned so there is no need for a service call.
Smart Lasers – automatically track laser lifetime. Patented Autoalignment – keeps the excitation laser, the Raman scattering, and the visual light paths precisely aligned to the same sampling point for maximum sampling precision. No manual alignment necessary.
• Optional tube and vial sampling accessory • Fiber optic probe sampling option
Software • Comprehensive OMNIC software suite for full instrument control and data processing • OMNIC Array Automation provides automated data collection from sample arrays and post-collection data processing • OMNIC Atlµs™ software permits sample mapping and image analysis • TQ Analyst™ with chemometrics for comprehensive data analysis • Extensive Raman libraries and easy to use search capabilities
Light Microscope • Research grade microscope • 4X, 10X, 20X, 50X and 100X microscope objectives, with brightfield/darkfield, oil immersion, and long working distance options • Standard and brightfield/darkfield illuminators • Fluorescence and DIC light microscopy options
SmartLock Technology for Reproducible Results
• Digital video camera for video data capture • Trinocular for visual and video imaging (binocular or video only optional) SmartLock Filters
Users can configure the DXR Raman microscope with up to three different excitation wavelengths – at 532, 633 and 780 nm. The lasers, together with the appropriate filters and gratings, lock into place using SmartLock technology for precisely reproducible results. OMNIC™ software recognizes each component, records the serial numbers and checks for compatibility. A convenient storage container is provided for when the components are not in use.
SmartLock Grating
Ensures reproducible spectra even with multiple grating exchanges (plot shows an overlay of 150 spectra; grating exchanged between each collect).
Maintenance • Single beam-path spectrometer for robustness and simple alignment
Single USB Connection – full instrument control from either a desktop or laptop computer through a single USB port.
• Spectrograph with no moving parts for high reliability • Minimal service requirements
Automated Calibration – spectrograph, laser and Raman intensity calibrations are completely automated by OMNIC software using standards located in the alignment/calibration tool. SmartLock Lasers
Fine-adjust Mirrors – software-controlled mirror adjustments to maintain peak performance.
Laser Power Regulator – compensates for changes in laser power output and guarantees consistent power at the sample.
• All consumables, including lasers, are user-replaceable • Software-controlled alignment and calibration performed routinely by the user
Validation • ValPro™ System Qualification package for full validation to meet all regulatory requirements
DXR Micro Interior 1-23-08
1/23/08
7:43 PM
Page 1
S I M P LY T H E B E S T
PERFORMANCE WITHOUT COMPROMISE
Raman Spectrometer
The Performance You Need
Invaluable – Now and into the Future
Effortless Maintenance
• Class I laser safe; safe to use in the open lab (Class IIIb optional)
The DXR Raman microscope is designed from start to finish as a robust analytical tool. This means no compromises on the performance features that matter.
The DXR Raman microscope is the platform that expands to meet your changing needs.
A fully calibrated and aligned instrument delivers reproducible results dependably. With its deceptively simple design and minimal moving parts, the DXR Raman microscope is easy to maintain. Patented autoalignment, calibration and other features make it easy to incorporate routine instrument maintenance into standard lab operating procedures.
• Convenient storage container for additional lasers, gratings and filters
Precision
a
b
Low Brightness
High Brightness
High Brightness Lasers – focus all of the laser energy on the target for better contrast and no wasted laser power. The absence of scatter from material surrounding the target guarantees true confocality.
Fiber optics for remote sampling
Visual Light Path
on ati cit x E
Patented Autoalignment – precision sampling with minimum interference from surrounding materials.
• High-resolution gratings for difficult to resolve bands. 50 cm-1 to 1800 cm-1 (fingerprint region) • SmartLock technology for reproducibly mounting lasers, gratings, filters, fiber port • Smart components report identity and serial numbers for compatibility checking, traceability and laser lifetime tracking • Patented Autoalignment procedure to ensure optimal alignment and precision sampling • Rapid automated calibration to ensure validity of results • Laser Power Regulator * Spectral range for the 780 nm excitation laser is 50 cm-1 to 3300 cm-1
Sampling Easy-to-maintain Spectrograph – no moving parts, unique design optimizes performance at all wavelengths.
• Software-controlled motorized microscope stage for automated data collection and sample mapping (manual stage optional) • Multi-well adapter for automated multi-well plate sampling • Spacious microscope stage compartment for large samples, heated, cooled and other specialty stages User-replaceable Components – no service calls required to replace a laser.
Add objectives for additional versatility
r se La
• Full range gratings for complete spectra in one shot. 50 cm-1 to 3500 cm-1, 5 cm-1 spectral resolution*
Pre-aligned Smart Components – factory-aligned components permit lasers, gratings and filters to be exchanged easily. Lasers, gratings, filters, fiber launcher identify themselves by serial number and wavelength. OMNIC software checks for component compatibility.
Exceptional Spatial Resolution – analyze the smallest sample features with confidence. (a) and (b): SEM of spatial resolution target and Raman map, respectively; (c) cross-section of the Raman map, demonstrating better than 1-micron resolution.
Ra ma n Sc att er
• Spectrometer with no moving parts for dependable performance
DIC and fluorescence for greater flexibility in sample imaging
Choice of Spectral Resolution – choose standard spectral resolution for routine analysis. For hard-toresolve bands high resolution gratings are available for all three lasers.
c
• 532-, 633- and 780-nm high-brightness lasers; factory aligned, user-interchangeable
Fully Automated Confocal Microscopy – 2-micron resolution for depth profiling and inclusion analysis. Depth profile of food packaging.
Superior Visual Imaging
• Trinocular • Full range of Olympus microscope options
Switch to brightfield or darkfield illumination
Multiple Lasers – Be ready for any sample. Expand the capabilities of the DXR Raman microscope by adding a second or third excitation laser. Minimize fluorescence interference, or enhance sensitivity by up to 10-fold. Facilities with more than one DXR microscope or SmartRaman can share lasers, gratings and filters between instruments for even greater versatility. Components are automatically recognized by Smart technology and pre-aligned so there is no need for a service call.
Smart Lasers – automatically track laser lifetime. Patented Autoalignment – keeps the excitation laser, the Raman scattering, and the visual light paths precisely aligned to the same sampling point for maximum sampling precision. No manual alignment necessary.
• Optional tube and vial sampling accessory • Fiber optic probe sampling option
Software • Comprehensive OMNIC software suite for full instrument control and data processing • OMNIC Array Automation provides automated data collection from sample arrays and post-collection data processing • OMNIC Atlµs™ software permits sample mapping and image analysis • TQ Analyst™ with chemometrics for comprehensive data analysis • Extensive Raman libraries and easy to use search capabilities
Light Microscope • Research grade microscope • 4X, 10X, 20X, 50X and 100X microscope objectives, with brightfield/darkfield, oil immersion, and long working distance options • Standard and brightfield/darkfield illuminators • Fluorescence and DIC light microscopy options
SmartLock Technology for Reproducible Results
• Digital video camera for video data capture • Trinocular for visual and video imaging (binocular or video only optional) SmartLock Filters
Users can configure the DXR Raman microscope with up to three different excitation wavelengths – at 532, 633 and 780 nm. The lasers, together with the appropriate filters and gratings, lock into place using SmartLock technology for precisely reproducible results. OMNIC™ software recognizes each component, records the serial numbers and checks for compatibility. A convenient storage container is provided for when the components are not in use.
SmartLock Grating
Ensures reproducible spectra even with multiple grating exchanges (plot shows an overlay of 150 spectra; grating exchanged between each collect).
Maintenance • Single beam-path spectrometer for robustness and simple alignment
Single USB Connection – full instrument control from either a desktop or laptop computer through a single USB port.
• Spectrograph with no moving parts for high reliability • Minimal service requirements
Automated Calibration – spectrograph, laser and Raman intensity calibrations are completely automated by OMNIC software using standards located in the alignment/calibration tool. SmartLock Lasers
Fine-adjust Mirrors – software-controlled mirror adjustments to maintain peak performance.
Laser Power Regulator – compensates for changes in laser power output and guarantees consistent power at the sample.
• All consumables, including lasers, are user-replaceable • Software-controlled alignment and calibration performed routinely by the user
Validation • ValPro™ System Qualification package for full validation to meet all regulatory requirements
DXR Micro Interior 1-23-08
1/23/08
7:43 PM
Page 1
S I M P LY T H E B E S T
PERFORMANCE WITHOUT COMPROMISE
Raman Spectrometer
The Performance You Need
Invaluable – Now and into the Future
Effortless Maintenance
• Class I laser safe; safe to use in the open lab (Class IIIb optional)
The DXR Raman microscope is designed from start to finish as a robust analytical tool. This means no compromises on the performance features that matter.
The DXR Raman microscope is the platform that expands to meet your changing needs.
A fully calibrated and aligned instrument delivers reproducible results dependably. With its deceptively simple design and minimal moving parts, the DXR Raman microscope is easy to maintain. Patented autoalignment, calibration and other features make it easy to incorporate routine instrument maintenance into standard lab operating procedures.
• Convenient storage container for additional lasers, gratings and filters
Precision
a
b
Low Brightness
High Brightness
High Brightness Lasers – focus all of the laser energy on the target for better contrast and no wasted laser power. The absence of scatter from material surrounding the target guarantees true confocality.
Fiber optics for remote sampling
Visual Light Path
on ati cit x E
Patented Autoalignment – precision sampling with minimum interference from surrounding materials.
• High-resolution gratings for difficult to resolve bands. 50 cm-1 to 1800 cm-1 (fingerprint region) • SmartLock technology for reproducibly mounting lasers, gratings, filters, fiber port • Smart components report identity and serial numbers for compatibility checking, traceability and laser lifetime tracking • Patented Autoalignment procedure to ensure optimal alignment and precision sampling • Rapid automated calibration to ensure validity of results • Laser Power Regulator * Spectral range for the 780 nm excitation laser is 50 cm-1 to 3300 cm-1
Sampling Easy-to-maintain Spectrograph – no moving parts, unique design optimizes performance at all wavelengths.
• Software-controlled motorized microscope stage for automated data collection and sample mapping (manual stage optional) • Multi-well adapter for automated multi-well plate sampling • Spacious microscope stage compartment for large samples, heated, cooled and other specialty stages User-replaceable Components – no service calls required to replace a laser.
Add objectives for additional versatility
r se La
• Full range gratings for complete spectra in one shot. 50 cm-1 to 3500 cm-1, 5 cm-1 spectral resolution*
Pre-aligned Smart Components – factory-aligned components permit lasers, gratings and filters to be exchanged easily. Lasers, gratings, filters, fiber launcher identify themselves by serial number and wavelength. OMNIC software checks for component compatibility.
Exceptional Spatial Resolution – analyze the smallest sample features with confidence. (a) and (b): SEM of spatial resolution target and Raman map, respectively; (c) cross-section of the Raman map, demonstrating better than 1-micron resolution.
Ra ma n Sc att er
• Spectrometer with no moving parts for dependable performance
DIC and fluorescence for greater flexibility in sample imaging
Choice of Spectral Resolution – choose standard spectral resolution for routine analysis. For hard-toresolve bands high resolution gratings are available for all three lasers.
c
• 532-, 633- and 780-nm high-brightness lasers; factory aligned, user-interchangeable
Fully Automated Confocal Microscopy – 2-micron resolution for depth profiling and inclusion analysis. Depth profile of food packaging.
Superior Visual Imaging
• Trinocular • Full range of Olympus microscope options
Switch to brightfield or darkfield illumination
Multiple Lasers – Be ready for any sample. Expand the capabilities of the DXR Raman microscope by adding a second or third excitation laser. Minimize fluorescence interference, or enhance sensitivity by up to 10-fold. Facilities with more than one DXR microscope or SmartRaman can share lasers, gratings and filters between instruments for even greater versatility. Components are automatically recognized by Smart technology and pre-aligned so there is no need for a service call.
Smart Lasers – automatically track laser lifetime. Patented Autoalignment – keeps the excitation laser, the Raman scattering, and the visual light paths precisely aligned to the same sampling point for maximum sampling precision. No manual alignment necessary.
• Optional tube and vial sampling accessory • Fiber optic probe sampling option
Software • Comprehensive OMNIC software suite for full instrument control and data processing • OMNIC Array Automation provides automated data collection from sample arrays and post-collection data processing • OMNIC Atlµs™ software permits sample mapping and image analysis • TQ Analyst™ with chemometrics for comprehensive data analysis • Extensive Raman libraries and easy to use search capabilities
Light Microscope • Research grade microscope • 4X, 10X, 20X, 50X and 100X microscope objectives, with brightfield/darkfield, oil immersion, and long working distance options • Standard and brightfield/darkfield illuminators • Fluorescence and DIC light microscopy options
SmartLock Technology for Reproducible Results
• Digital video camera for video data capture • Trinocular for visual and video imaging (binocular or video only optional) SmartLock Filters
Users can configure the DXR Raman microscope with up to three different excitation wavelengths – at 532, 633 and 780 nm. The lasers, together with the appropriate filters and gratings, lock into place using SmartLock technology for precisely reproducible results. OMNIC™ software recognizes each component, records the serial numbers and checks for compatibility. A convenient storage container is provided for when the components are not in use.
SmartLock Grating
Ensures reproducible spectra even with multiple grating exchanges (plot shows an overlay of 150 spectra; grating exchanged between each collect).
Maintenance • Single beam-path spectrometer for robustness and simple alignment
Single USB Connection – full instrument control from either a desktop or laptop computer through a single USB port.
• Spectrograph with no moving parts for high reliability • Minimal service requirements
Automated Calibration – spectrograph, laser and Raman intensity calibrations are completely automated by OMNIC software using standards located in the alignment/calibration tool. SmartLock Lasers
Fine-adjust Mirrors – software-controlled mirror adjustments to maintain peak performance.
Laser Power Regulator – compensates for changes in laser power output and guarantees consistent power at the sample.
• All consumables, including lasers, are user-replaceable • Software-controlled alignment and calibration performed routinely by the user
Validation • ValPro™ System Qualification package for full validation to meet all regulatory requirements
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ANSWERS YOU CAN TRUST
Patent g Pendin
T HE R AMAN M ICROSCOPE D ESIGNED W ITH Y OU I N M IND
Results Made Easy
From the Experts in Raman Microscopy
The DXR Raman microscope lets the user focus on the results, not on learning new techniques and procedures. At Thermo Scientific, we design instruments that take care of the details.
With many years of experience in Raman and FT-IR microscopy, Thermo Fisher Scientific has designed the DXR Raman microscope to encompass all the benefits of Raman microscopy in one simple, easy-to-use instrument. The DXR Raman microscope includes patented technology to take the guesswork out of achieving optimal performance – routinely and reproducibly. This is the Raman microscope that the busy analytical lab cannot afford to be without.
Top Quality Results Made Easy – unique software features optimize signal-to-noise to reveal even the finest details in a spectrum of Tyrian Purple pigment.
Your Applications and Raman Microscopy You are going to find yourself relying on your DXR Raman microscope for many of your most challenging applications. For small particle analysis, the 1-micron spatial resolution is invaluable. In addition, the DXR Raman microscope gives you true confocal depth profiling abilities, enabling you to look for evidence of inclusions or impurities and characterize multi-layer polymer films. Raman provides many benefits:
Autofocus – optimizes the focus to maximize the Raman signal automatically. Smart Background – the DXR Raman microscope collects background data during instrument downtime, so that the user never has to wait.
• Rapid and non destructive • No sample preparation • No water interference – easy to measure aqueous samples • Complementary to FT-IR • Easy access to low vibrational frequencies, making it easy to analyze inorganic molecules
Automatic Fluorescence Correction – automatically corrects for fluorescence interference. Available for all excitation lasers.
Laser Power Regulator – compensates for changes in laser power output and guarantees consistent Raman response. Legend: Zone A: The Laser Power Regulator controls the laser power reaching the sample to ensure reproducible results. Zone B: As the laser power declines over its lifetime, measurements become non-reproducible on instruments lacking a Laser Power Regulator. Zone C: Beyond the expected laser lifetime. The DXR Raman microscope can still be used reproducibly at lower power levels, however the laser should be replaced in order to obtain maximum power output.
Automatic Intensity Correction – compensates for detector wavelength dependence.
• Dyes and Chemicals • Fibers • Pharmaceuticals • Nanotechnology • Packaging • Polymers • Paper Manufacturing • Forensics • Gemstones • Geology • Art Restoration and the Study of Cultural Artifacts
Raman microscopy is employed at many stages in the manufacturing process from research to final product QC: • Methods Development •R&D • QA/QC • Reverse Engineering • Failure and Defect Analysis
The DXR Raman Microscope The DXR Raman microscope is a research-quality tool designed specifically for today’s multi-purpose analytical labs. This is the microscope for the user who needs the high spatial resolution, ease of sample preparation and power of Raman microscopy, and who has neither the time nor the desire to become a Raman expert. The DXR Raman microscope delivers spatial resolution that is as good or better than any instrument on the market, together with unique features designed to make it as easy as possible to get high quality results.
Autoexposure – the DXR Raman microscope calculates the exposure time and number of exposures for optimal sensitivity.
Raman microscopy is of critical value in industrial and non-industrial environments alike. New applications are being discovered daily in:
• Patented autoalignment system for guaranteed optimal performance • True point-and-shoot Raman capability • Exceptional spatial resolution • Superb visual quality
Unlock the power of Raman microscopy, effortlessly…
The Answers You Need Whether it’s library searches to identify unknowns, data interpretation for large collections of samples, or mapping the distribution of key components, the DXR Raman microscope and the OMNIC software suite make it easy to focus on the answers.
Identify Unknowns Sophisticated Spectral Analysis – InterpretIR+™ identifies key spectral features in a nylon fiber sample.
The most extensive Raman libraries
Sophisticated Mapping and Data Analysis OMNIC Atlµs mapping software combines hyperspectral mapping with image analysis algorithms and chemometric tools. Analyze sample cross-sections, extract sample component information using MCR then map and quantify the distribution of components. Add mapping capability to the DXR Raman microscope for ever more sophisticated applications.
Overlay of chemical and video map to show distribution of components
Atlµs generates an information-rich map of a painkiller tablet
Distribution of the two major tablet components generated by MCR analysis of the hyperspectral Atlµs map
Laboratory Solutions Backed by Worldwide Service and Support With its user-friendly patented autoalignment and calibration, plus its user-replaceable lasers, gratings and filters, the DXR Raman microscope has been designed to need
In addition to these offices, Thermo Fisher Scientific maintains a network of representative organizations throughout the world.
little service attention. However, we know that in today’s busy, multifunctional laboratories you cannot afford to be without your workhorse instruments for even the shortest time. With the most extensive world-wide organization of field service engineers, you can count on us to keep you up and running. First class service and support allow you to get the most out of your microscope and samples. With our expertise in applications support, we offer comprehensive training to take you to the next level.
The Thermo Scientific Family of Raman Spectrometers Nicolet Almega XR The Thermo Scientific Nicolet™ Almega™ XR is a highperformance dispersive Raman spectrometer. Fully automated and with micro and macro sampling combined in one instrument, the Almega XR offers the ultimate in performance, automation and flexibility. The Almega XR is ready for any sample and meets the needs of even the most demanding applications.
NXR FT-Raman Series The Nicolet NXR FT-Raman spectrometer uses 1064or 976-nm excitation lasers for radical reduction in fluorescence interference. With the most extensive sampling accessories available, including the FT-Raman MicroStage for microscopic analysis, the NXR FT-Raman spectrometer can be configured either as a dedicated, stand-alone system or as an accessory for FT-IR spectrometers.
DXR SmartRaman Built on the same platform as the DXR Raman microscope, the DXR SmartRaman spectrometer is dedicated to bulk sample analysis. It is intended for use in busy multi-purpose analytical labs, where the users are looking for reproducible and accurate results from a dependable, low maintenance instrument.
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Thermo Electron Scientific Instruments LLC, Madison, WI USA is ISO Certified. The DXR Raman microscope is a Class IIIb laser-safe product, unless installed with the Class I Laser Safety Enclosure. Installation of a fiber optic probe launcher and fiber probe will convert all microscopes to Class IIIb laser-safe, even with the Laser Safety Enclosure installed. ©2008 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific Inc. and its subsidiaries. Specifications, terms and pricing are subject to change. Not all products are available in all countries. Please consult your local sales representative for details. BR51343_E 01/08M
