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Electrophysiology Experts
Product Range Overview
Manipulators Patchstar
The PatchStar is an ultra-stable, super smooth micromanipulator with extremely low electrical noise micromanipulator. With a versatile, modular design and user friendly responsive controls, the PatchStar is perfect for a wide range of electrophysiological, microinjection and other demanding positioning requirements. Ergonomically designed in collaboration with leading physiologists, the PatchStar will increase productivity and ensure quality recordings, resulting in it being the first choice in many labs worldwide. Attention to detail and modular versatility means that the PatchStar can adapt to your present and future experimental needs. The ability to easily computer control and multiplex these devices ensure that they are suitable for the most demanding applications. A wide range of user interfaces are available: Control Cube - compact and comfortable to use, this popular wheeled design gives fingertip control and excellent functionality. “Speed”, “Home In”, “Home Out”, “Memory” and “Step” positions can all be controlled from buttons on the cube. Joystick - Ergonomic design offers intuitive directional control in 3 axes. Proportional movement and a speed change button allow you to comfortably and naturally use the joystick whilst concentrating on your experiment. PatchPad - This alternative control system, with panel mounted wheels and colour touch screen with function buttons, offers maximum versatility and control. Double PatchStar system
PC - Create your own speed settings; customise the wheel directions and pre-program step size and direction together with home in / out functionality. The easy to use graphical interface gives full control of the manipulator and comes free of charge with every PatchStar.
Control Cube
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Features & Benefits Q
Ultra Stable - Less than 1 micron of drift in 2 hours, allows long term experiments
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Low noise electronics - suitable for single channel recordings
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Super smooth motion - 20 nm resolution and quality engineering means that you can confidently position your electrode or probe
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Choice of Controls - Control cube, Joystick, PatchPad or PC
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Four axes of motion - maximum positioning versatility
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Easy pipette exchange - increased productivity and reproducible positioning
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Auto angle detection - pipette axis motion for accurate sub surface positioning
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Modular Design - easily configured for left or right-handed operation
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Choice of Accessories - customise your PatchStar to suit you
PatchStar with swing up bracket
Mounting Solutions Slice Platforms and Microscope Stages
A crucial part in every experimental set-up is a stable mounting system. Scientifica offer height adjustable platforms for upright and inverted microscopes from Olympus, Zeiss, Nikon and Leica. Used in combination with these platforms are either manual or motorised translation stages which allow the microscope objective to be positioned over the complete preparation.
Upright SlicePlatform The SlicePlatform provides a large, extremely stable mounting surface onto which several manipulators and the sample can be mounted. Fully height adjustable legs accommodate any microscope, whilst the unique rotating slotted inserts mean that it can be attached to any standard vibration platform. The sliding carriage design enables you to easily position whichever manipulators you choose, including the PatchStar, at any orientation to the microscope objective.
Inverted SlicePlatform Similar to the upright solution, this innovative design is specific for inverted microscopes and provides a mounting surface onto which several manipulators and the sample can be mounted. The height adjustable legs make this platform compatible with microscopes from Olympus, Nikon, Leica and Zeiss. The sliding carriages allow manipulators to be easily positioned. UMS with Z focus SlicePlatform with manual XY and two PatchStars
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Universal Motorised Stage UMS The Scientifica UMS provides rapid, accurate and intuitive remote control which removes the effort and potential for error from the adjustment process. The 400mm x 200mm UMS provides complete microscope support and the 50mm of travel in both the X and Y axes allows you to roam the largest of samples. An optional Z axis focus control is also available providing fully automated control. Speed can be controlled down to 1 micron per second, making this motorised stage more accurate than any manually adjustable system. Choose between a joystick or control cube for positioning your stage with all systems coming complete with the option of PC control. The ability to store and recall up to 50 memory positions in X, Y and Z (focus) ensures that every site of interest can be referenced.
Nikon Eclipse FN1 with SlicePlatform and UMS
The ultra low noise electronics means you can continue to record sensitive signals even during microscope adjustment.
Manual Stage
Axioskop 2 FS Plus with SlicePlatform & UMS
The manual stage offers positioning control of your microscope. High capacity crossed roller bearings ensure 25 mm of super smooth travel in X & Y axes. High performance micrometers allow fingertip control and the capability to change from right to left-handed operation provides added convenience. Its large 200 x 400 mm footprint means that the stage can support even the heaviest of microscopes.
Olympus IX71 with inverted SlicePlatform and manual XY stage
PatchPro PatchPro Systems
The PatchPro system is a fully integrated patch clamping solution and is a revolutionary approach to patch clamp electrophysiology. It allows the user to control manipulators, microscope platforms, microscope focus and temperature control all from one neat, simple user console. With the versatility to have up to 12 individual modules, the PatchPro will be perfect for your current and future experimental needs. At any time you can add additional manipulators or heater units. Exciting new modules are planned for the future and will be compatible with the existing PatchPro system. The simple, intuitive, multiplexing control options can be by single or multiple control cubes, joysticks or a combination of both. Fully upgradeable with future proof computer control at no extra cost. The PatchPro is available in a choice of configurations, alternatively custom systems can be assembled.
Zeiss Axioskop 2 FS Plus with PatchPro 2000
Olympus BX51-WI with PatchPro 1000
PatchPro PRO-1000 Compatible with all major upright microscopes. This system includes; 2 Ultra fine PatchStar manipulators. Motorised microscope translation stage (UMS) with focus module. In line temperature control heater module. Two Post and Platforms for easy positioning of manipulators. An additional Post and Platform for holding your sample chamber. User Console with your choice of Joystick, Control cube or a combination of both. PC control software.
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Nikon Eclipse FN1 with PatchPro 3000
PatchPro PRO-3000
Olympus IX71 with PatchPro 4000
Compatible with all major upright microscopes. This system includes: 2 Ultra fine PatchStar manipulators. In line temperature control heater module. Motorised Movable Top Plate (MMTP) with Z focus module, sliding manipulator carriages and rotational sample plate holder. User Console with your choice of Joystick, Control cube or a combination of both. PC control software.
PatchPro PRO-4000 PatchPro PRO-2000 Compatible with all major upright microscopes. This system includes: 2 Ultra fine PatchStar manipulators. Motorised microscope translation stage (UMS) with focus module. In line temperature control heater module. SlicePlatform with sliding manipulator carriages and a rotational sample plate holder. User Console with your choice of Joystick, Control cube or a combination of both. PC control software.
Compatible with all major inverted microscopes. This system includes: 2 Ultra fine PatchStar manipulators. In line temperature control heater module. Unique Inverted Sample Platform with sliding manipulator carriages and a rotational sample plate holder. Motorised microscope translation stage (UMS) with focus module. User Console with your choice of Joystick, Control cube or a combination of both. PC control software.
Imaging Platforms Imaging Platforms
Movable Top Plate (MTP)
Cutaway image of Motorised Movable Top Plate
Motorised Movable Top Plate (MMTP)
The MTP is an ultra stable microscope stage ideal for use with confocal or multiphoton microscopes. In situations where your microscope is firmly attached to the table top, the MTP still provides you with the freedom to manually search for different areas of interest in different fields of view of the microscope objective. The Top Plate can be moved over a distance of 25mm in X and Y direction with fingertip control using micrometers; the smoothness of the motion allows the investigator to maintain a patched cell whilst moving the stage. Combining the height adjustable legs with a large condenser working area makes the Movable Top Plate compatible with all leading brands of upright microscopes.
Compatible with all major upright microscopes the MMTP is ideal for use with a confocal or multiphoton system. It offers 25 mm of super smooth X & Y travel with a resolution of 20 nm. The manipulators and sample can be positioned as one, allowing movement to different fields of view of the objective, whilst the microscope remains fixed. This means that you can image different areas of interest whilst maintaining delicate patch clamp experiments. Up to 50 memory positions can be stored and recalled in XY & Z (focus) axes. The ultra low noise electronics means you can continue to record sensitive signals even during sample adjustment. Platform positioning can be carried out by either a joystick, control cube or with a PC.
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Close up of manual Movable Top Plate
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Post and Platform (P&P)
LBM 7
Build your experiments on a firm base.
The LBM-7 was designed and developed in conjunction with scientists to be stable, have low drift and be easy to use. It bridges the gap between coarse manipulators and micromanipulators.
The Scientifica Post and Platform offers a versatile yet very stable platform for mounting manipulators, tissue samples and other equipment around your microscope. The choice of a bolt down or a magnetic base means that the P&P will be suitable for many different table tops. The platform is fully height adjustable and has the benefit of a convenient swing in/swing out function. Post and Platform with magnetic and bolt down base
Affectionately known as the Little Blue Manipulator, this device can be easily configured from left to right-handed. With seven axes of movement, four liner and three rotational, combined with micron resolution, the LBM-7 was designed to serve the scientist in a broad range of applications that include: Q
Positioning Stimulating Electrodes
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Inserting extracellular recording probes
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Aligning perfusion and drug delivery systems
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Impaling oocytes
LBM7
Drug Delivery
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Chambers & Perfusion SliceMate
Pumped Perfusion System (PPS)
The SliceMate utilizes cutting edge technology to give outstanding temperature control in a compact, easy and convenient package which replaces the clumsy, slow reacting and problematic water bath designs.
Control the delivery of up to 8 solutions to your experiment using the Pumped Perfusion System.
With no electrical noise the digital temperature control and twin temperature sensors ensure that the SliceMate offers fast, repeatable temperature regulation. A peltier element allows you to heat or cool the solution whilst a data file of the actual temperature is recorded. The bath itself can be easily removed and exchanged for cleaning, as can all of the tubing within the system. Different size baths are available for a variety of preparations.
Designed for electrophysiological experiments, the ultra low noise controller ensures that there is no electrical noise from the peristaltic pump or the high performance pinch valves. This system comes with a clear and simple to use Graphical User Interface which allows you the control the speed of the peristaltic pump, as well as the switching and timing of each perfusion channel. Perfusion rates between 0.5 - 20 ml per minute are easily reproduced. Each solution can be re-circulated or sent to waste simply by the click of a mouse. The pinch valves and disposable tubing ensure easy maintenance making the PPS a reliable drug delivery system.
SliceMate with mouse chamber
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Pumped perfusion system
Complete Systems Complete Systems FibreMaster
SliceMaster
Designed specifically to target Safety Pharmacology applications, the FibreMaster offers increased throughput and productivity whilst at the same time minimizing animal usage.
This unique, high throughput system allows a single user to record from up to 8 tissue preparations at one time.
The fully integrated system includes: manipulation, amplifiers, temperature control, stimulation, antivibration, optical systems and perfusion control. Maximising tissue viability, the FibreMaster is an easy to use system which allows an experimenter to record from up to three chambers at once. The FibreMaster can be customized to suit many experiments.
This proven technology is based around existing methodology to offer reproducible and robust experiments whilst optimizing tissue usage. The integrated system can be combined with many existing data acquisition methods, making the SliceMaster easy to use, thereby maximizing quality data output. Each SliceMaster can be customized to suit different experimental needs and can be configured from two to eight stations. A variety of recording techniques that include extracellular, intracellular and voltammetry can be accommodated.
8 station SliceMaster 3 station FiberMaster
Formed in 1997 Scientifica specialises in supplying innovative, high quality products that offer many benefits to research using electrophysiology and associated techniques. Listening carefully to our customers requirements, and thinking laterally around a problem, has meant that the company's product range is used from simple to the most demanding applications. Scientifica has headquarters in Uckfield and a production facility in Maidenhead, both in the South East of the UK. Our systems are used in laboratories throughout the world and include many top universities, research centres and pharmaceutical companies.
Your nearest distributor
Tel: +44(0)1825 749933
Fax: +44(0)1825 749934
Email:
[email protected] Web: www.scientifica.uk.com SCIENTIFICA LTD Kingfisher Court Brambleside Bellbrook Industrial Estate Uckfield East Sussex TN22 1QQ UK
