Research Report 2014 – 2015 Psychiatry And Psychology

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2014 – 2015 Research Report Psychiatry and Psychology Department Chairs TABLE OF CONTENTS 2 Introduction Left to right: Clark, Frye, Kung Mark A. Frye, M.D. (Chair, Rochester, Minnesota) Matthew M. Clark, Ph.D. (Chair of Research) Simon Kung, M.D. (Vice-chair of Research) 4 Clinical Disorders 16 Novel Methods for Understanding 20 Novel Methods for Intervening 24 Medical Diseases Interface with Psychiatry and Psychology 44 Science of Health Care Delivery 46 Career Development 53 Resident and Fellow Researchers 59 The Research Psychometrics Resource Teresa A. Rummans, M.D. (Jacksonville, Florida) 60 Research Study Team Cynthia M. Stonnington, M.D. (Scottsdale, Arizona) Kristin Vickers Douglas, Ph.D. (Chair of Education) Brian A. Palmer, M.D. (Vice-chair of Education) 1 Welcome to the 2014 - 2015 Research Report of the Mayo Clinic Department of Psychiatry & Psychology T hank you for your interest in our Department of Psychiatry and Psychology and learning more about our recent research accomplishments. Our department plays an essential role in Mayo Clinic’s goal of inspiring hope and contributing to health and well-being by providing the best care to every patient through integrated clinical practice, education, and research. At Mayo Clinic’s three main campuses -- Rochester, Minnesota; Jacksonville, Florida; and Scottsdale, Arizona -- there are over 150 psychiatrists and psychologists, joined by over 200 allied health staff to meet the needs of the patient. Our flagship clinical programs include our Psychiatric Hospital, Mayo Clinic Depression Center, Pain Rehabilitation Program, Addiction Treatment Center, Child and Adolescent Programs, Neurocognitive Assessment and Treatment Programs, Behavioral Medicine Program, and Integrated Care Programs. Our department provides numerous educational programs including Graduate Medical Education residencies in Adult and Child and Adolescent Psychiatry, fellowships in Medical Psychology (Clinical Child Psychology, Clinical Health Psychology, and Clinical Neuropsychology), Geriatric Psychiatry, Psychosomatic Medicine, Sleep Medicine, and Addiction Psychiatry. Due to the expertise and range of these clinical and educational programs, our Department of Psychiatry and Psychology was ranked as one of the Top Ten Psychiatry Departments in the country by the U.S. News and World Report in 2014. Many of our research projects focus on clinical interventions and our clinical programs guide and shape our research efforts, which in combination seek to provide the best care to every patient every day. The Department of Psychiatry and Psychology continues to highlight research teams in our annual 2014-15 departmental research report. We want to highlight the value, importance, and productivity of research teams within our department. These research teams can also be found across the Mayo Clinic sites which include Minnesota, Florida, and Arizona, and also involve the many hospitals that comprise the Mayo Clinic Health System. For example, the Neuropsychology, Aging, and Cognition Research Team has scientific investigators across all three campuses. Research teams within our department include an array of health care professionals and focus on the evaluation and treatment of a range of mental health problems and their impact on patients and their families. The Mayo Clinic Depression Center Research Team, which includes psychiatrists, psychologists, nurses, and social workers, conducting clinically relevant research in treatment-resistant depression and bipolar disorder, is an example of a highly productive multidisciplinary clinical research team. Additionally, many investigators in our department are engaged in research projects with other departments or centers of excellence across our academic medical center. Our department has investigators in The Mayo Clinic Comprehensive Cancer Center, The Bariatric Surgery Center of Excellence, and The Alzheimer’s Disease Research Center. Finally, we encourage the participation of research with other academic centers, collaborations, and multisite studies. The University of Minnesota, the Karolinska Institute in Sweden, and the National Network of Depression Centers are outstanding examples of collaborative multicenter research projects. ——— If you are interested in contacting any of the investigators highlighted in this report, please contact our department at 507-266-5100. 6 2 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY In 2014, our Department had 27 funded grants where the Principal Investigator was a faculty member in our department. We also contributed to a significant number of funded studies as co-investigators across numerous departments at Mayo Clinic. The wide portfolio and funding sources in our Department include: • Agency for Healthcare Research and Quality • Center of Medicare and Medicaid Services • National Cancer Institute • National Institute on Aging • N  ational Institute of Alcohol Abuse and Alcoholism • National Institute on Drug Abuse • National Institute of General Medical Science • National Institute of Mental Health Meeting the needs of underserved populations and addressing health disparities is a priority of our department’s clinical, educational, and research programs. To address the problem, our department has numerous academic and research projects focused on meeting the needs of underserved populations, developing creative mental health treatment delivery systems, and tailoring interventions for specific underserved populations. Many people with mental health issues struggle to get needed medical, psychiatric and psychological care. Specific examples include: Expanding access to cognitive behavioral therapy (CBT) for childhood anxiety disorders via smartphones. Funded by the National Institute of Mental Health. Principal investigator: Dr. Stephen Whiteside. Family cancer literacy to promote mammography screening among Navajo women. Funded by the National Cancer Institute. Principal Investigator: Dr. Christi Patten. Healthy immigrant families: Working together to move more and eat well. Funded by the National Heart, Lung and Blood Institute. Coinvestigators: Drs. Bridget Biggs, Matthew Clark, and Christi Patten. Community intervention to reduce tobacco use among pregnant Alaska Native women. Funded by the National Cancer Institute. Principal Investigator: Dr. Christi Patten. National Network of Depression Centers. Principal Investigator: Dr. Mark Frye. Primary Care Initiatives: Coordinated Anxiety Learning and Management (CALM), Diabetes, Cardiovascular Disease, Depression, Comprehensive Pediatric and Adolescent Support Services Care Team (ComPASS), Early Management and Evidence-Based Recognition of Adolescents Living With Depression (EMERALD), and Depression Improvement Across Minnesota, Offering A New Direction (DIAMOND) Drs. David Katzelnick and Mark Williams. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 3 Mayo Clinic Depression Center ADULT INVESTIGATORS Renato D. Alarcón, M.D., MPH, William V. Bobo, M.D., MPH, Mark A. Frye, M.D., Astrid A. Hoberg, D.N.P., Theresa E. Hurne, LICSW, Simon Kung, M.D., Maria I. Lapid, M.D., Katherine M. Moore, M.D., Mary J. Moore, R.N., Kathleen A. Poppe, R.N., Randall L. Stone LICSW, Susannah J. Tye, Ph.D., Marin Veldic, M.D., Nicole D. Borrenpohl, M.S.N., R.N., C.N.P. PEDIATRIC INVESTIGATORS Third row, left to right: Tye, Stone, Frye, Borrenpohl, Kung Second row, left to right: Daily, Moore, K, Fuhrmeister, Hoberg, Moore, M Front row, left to right: Croarkin, Bobo, Hurne, Rosenblad Paul E. Croarkin, D.O., John E. Huxsahl, M.D., Jarrod M. Leffler, PhD, Jennifer L. Vande Voort, M.D. Depression is a significant public health problem, in this country and across the globe. Effective treatment can be challenging to identify for the individual and relapse is common after depression treatment. Therefore effective, individualized, long lasting treatments are needed for depression. The main focus of the Mayo Clinic Depression Center is to conduct clinically relevant research in treatment-resistant depression and bipolar disorder, in adults, adolescents and children. Our current research projects aim to build on our comprehensive and multidisciplinary depression treatment programs. Mayo Clinic Depression Center is a Center of Excellence for the National Network of Depression Centers, a network of 21 leading clinical and academic Centers of Excellence in the U.S. working to transform the field of depressive illness and related mood disorders. GRANTS National Institute of Mental Health RO1MH079261 1H-MR Spectroscopy of Bipolar Depression Before & After Lamotrigine Treatment. Frye (PI) 07/2009 - 12/2014. To Identify baseline MR glutamate / glutamine abnormalities in bipolar depression and evaluate whether these predict treatment response to lamotrigine. Myriad/Rules-Based Medicine A Feasibility Study to Develop a Biomarker Signature in Mood Disorders. Frye/Biernacka (PI) 09/2010 – 12/2014 This feasibility study will be looking at discovering proteomic platforms to identify serum samples from patients with mood disorders and controls. 6 4 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY AssureRX A pharmacokinetic/Pharmacodynamic Genetic Variation Treatment Algorithm versus Treatment as Usual for Management of Depression. Frye (PI) 07/2014 – 06/2016. Evaluate clinical value of genotyping. Microbiome CIM Florida The Microbiome of Depression. Frye/Richelson, (Pis) 07/2014 – 06/2016. Evaluate feasibility of testing microbiome in depression before and after treatment. Janssen Research and Development, LLC A Double-Blind Randomized Placebo-Controlled Study to Evaluate the Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Major Depressive Disorder Including Suicidal Ideation in Subjects at Imminent Risk for Suicide, Frye (PI) 05/2014 – 06/2015. AWARDS AND LEADERSHIP ROLES Altinbas K, Ozerdem A, Prieto ML,m Fuentes ME, Yalin N, Ersoy Z, Ayedmir O, Quiroz D, Oztekin S, Geske JR, Feeder SE, Angst J, Frye MA. A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression. J Affect Disord 2014 Jan; 152-154:478-482.Doi 10.1016/j.jad.2013.07.032. Renato D. Alarcón, MD, MPH. Co-Editor, Archivos de Psiquiatría, Madrid, Spain; Associate Editor, Asia-Pacific Psychiatry; Associate Editor, Transcultural Psychiatry. Calabrese JR, Frye MA, Yang R, Ketter TA, for the Armodafinil Treatment Trial Study Network. Efficacy and safety of adjunctive armodafinil in adults with major depressive episodes associated with bipolar I disorder: A randomized double-blind, placebocontrolled, multicenter trial. J Clin Psychiatry 2014 Jul 22 [Epub ahead of print] Croarkin PE, Nakonezny PA, Husain MM, Melton T, Buyukdura JS, Kennard BD, Emslie GJ, Kozel FA, Daskalakis ZJ. Evidence for Increased Glutamatergic Cortical Facilitation in Children and Adolescents With Major Depressive Disorder. JAMA Psychiatry. 2013 Jan 9:1-9. Fuentes Salgado ME, Sutor B, Albright RC, Frye MA. Every reason to discontinue lithium. Int Journal Bipolar Disorders, 2014 in press. Frye MA, Blier P, Tye, SJ. Concomitant benzodiazepine use attenuates ketamine response: Implications or large scale study design and clinical development. J Clin Psychopharmacology 2014, in press. Frye MA, Prieto ML, Bobo WV, Kung S, Veldic M, Alarcon RD, Moore KM, Choi D-s, Biernacka JM, Tye SL. Current landscape and unmet needs for treatment of bipolar depression. J Affect Disorder, 2014 in press. Kung, S, Alarcon RD, Williams MD, Poppe KA, Moore MJ, Frye MA. Comparing the Beck Depression Inventory-II (BDI-II) and Patient Health Questionnaire (PhQ-9) depression measures in an integrated mood disorders practice. J Affect Disord. 2013 Mar 5;145(3):341-3. Renato D. Alarcón, MD. MPH. Member, Board of Directors, World Association of Cultural Psychiatry. Renato D. Alarcón, MD. MPH. Workgroup member, DSM-V Committee, American Psychiatric Association. Mark A. Frye, MD. Scientific Reviewer. Member, NIMH Interventions Committee for Adult Disorders (ITVA), 2013 – Present. Susannah J. Tye, Ph.D., Co-Chair. Treatment Resistant Depression Task Force, National Network of Depression Centers. Mark A. Frye, MD. Member, Scientific Advisory Board, Depression and Bipolar Support Alliance. Simon Kung, MD. Recipient of a Mayo Clinic Individual Award for Service Excellence, 2012. PROFESSIONAL INTERNATIONAL PRESENTATIONS World Psychiatric Association’s XVI World Congress of Psychiatry, September 14-18, 2014, Madrid, Spain. Symposium Chair: Cardiovascular Disease and Obesity in Bipolar Disorder: Translational Research Focused on Epidemiology and Genetics “Mayo Clinic Bipolar: Focus on Metabolic Disorders”. Rasmussen KG, Hanson AJ, Frye MA, Galardy CW, Kung S, Lapid MI, Lineberry TW, Palmer BA, Ritter MJ, Schak KM, Sola CL. Serial Infusions of low-dose ketamine for major depression. Journal of Psychopharmacology 2013. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 5 CLINICAL DISORDERS KEY PUBLICATIONS Neuromodulation Research Group: Electroconvulsive Therapy, Transcranial Magnetic Stimulation, And Deep Brain Stimulation INVESTIGATORS From left to right: Fields, Tye, Frye, Lee From left to right: Min, Sampson, Citronowicz Back row, from left to right: Croarkin, Johnson, Rasmussen, Govrik, Ryan Front row, from left to right: Lapid, Kung, Brown, Farrow Sarah K. Brown, PA-C, Ron I. Citronowicz, PA-C, Paul E. Croarkin, D.O., Stacy L. Farrow, R.N., C.N.P., Julie A. Fields, Ph.D., Mark A. Frye, M.D., Michael N. Govrik, PA-C, Emily K. Johnson, D.N.P., R.N., C.N.P., Kendall H. Lee, M.D., Ph.D., Maria I. Lapid, M.D., Simon Kung, M.D., Paul H. Min, Ph.D., Brian A. Palmer, MD., Keith G. Rasmussen Jr, M.D., Debra A. Ryan, R.N., Shirlene M. Sampson, M.D., and Susannah J. Tye, Ph.D. The Neuromodulation Research Group at Mayo Clinic in Rochester, Minnesota, has been active in performing research regarding Electroconvulsive Therapy (ECT), Transcranial Magnetic Stimulation (TMS), and Deep Brain Stimulation (DBS). Dr. Rasmussen is leading a study investigating the use of daily right unilateral ultrabrief pulse ECT to potentially shorten the treatment duration of ECT for depression, without sacrificing effectiveness or cognitive impairments. Drs. Johnson and Kung are tracking real-world clinical outcomes of ECT for depression, with special attention to perceived memory impairments. Dr. Croarkin is leading a multi-site randomized double-blinded study of TMS versus sham for the treatment of adolescent depression, which will be the largest study of TMS in the adolescent population. Dr. Sampson has conducted openlabel TMS studies in patients with depression and comorbid conditions such as Post-traumatic Stress Disorder (PTSD), Borderline Personality Disorder, and chronic pain/fibromyalgia. Dr. Frye is leading a groundbreaking randomized study of DBS for treatment-resistant obsessive-compulsive disorder, in collaboration with Neurology and Neurosurgery. These examples of our neuromodulation research highlight the underlying goal: to expand our knowledge and treatment options for depression and other psychiatric illnesses, beyond conventional medications and psychotherapies. 6 6 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY CLINICAL DISORDERS GRANTS Brain and Behavior Research Foundation, NARSAD Young Investigator Award. Gutamatergic Neurotransmission in Youth at Risk for Bipolar Disorder (PI: Croarkin, Mentor: Frye) 07/201307/2015. NIMH Mentored Patient-Oriented Research Career Development Award. 1K23MH10026-01A1: Glutamate Probes in Adolescent Depression (PI: Croarkin, Mentor: Frye) 02/2013-01/2018. Paul and Betty Woolls Foundation (formerly The O’Shaughnessy Foundation): A Double-Blinded, Sham-Controlled Study Utilizing rTMS in Adolescents with Major Depressive Disorder. Funding period: 07/2012 – 06/2015; PI: Croarkin. KEY PUBLICATIONS Chopra A, Abulseoud OA, Sampson S, Lee KH, Klassen BT, Fields JA, Matsumoto JY, Adams AC, Stoppel CJ, Geske JR, Frye MA. Mood Stability in Parkinson Disease Following Deep Brain Stimulation: A 6-Month Prospective Follow-up Study. Psychosomatics 2014;55(5):478-84. Kozel FA, Croarkin PE, Mapes KS. A non-epileptiform event in the course of rTMS: a case for close physician monitoring. Brain Stimul 2013;6(6):970-2. Rasmussen KG. Do Patients With Personality Disorders Respond Differentially to Electroconvulsive Therapy?: A Review of the Literature and Consideration of Conceptual Issues. J ECT 2014 (epub ahead of print) Rasmussen KG, Ritter MJ. Some Considerations of the Tolerability of Ketamine for ECT Anesthesia: A Case Series and Review of the Literature. J ECT 2014 (epub ahead of print) Rasmussen KG. Propofol for ECT anesthesia: A review of the literature. J ECT 2014;30(3):210-5. Rasmussen KG, Kung S, Lapid MI, Oesterle TS, Geske JR, Nuttall GA, Oliver WC, Abenstein JP. A randomized comparison of ketamine versus methohexital anesthesia in electroconvulsive therapy. Psychiatry Res 2014;215(2):362-5. Wall CA, Croarkin PE, McClintock SM, Murphy LL, Bandel LA, Sim LA, Sampson SM. Neurocognitive effects of repetitive transcranial magnetic stimulation in adolescents with major depressive disorder. Front Psychiatry 2013;12(4):165. Croarkin PE, Nakonezny PA, Lewis CP, Zaccariello MJ, Huxsahl JE, Husain MM, Kennard BD, Emslie GJ, Daskalakis ZJ. Developmental aspects of cortical excitability and inhibition in depressed and healthy youth: an exploratory study. Front Hum Neurosci 2014;8:669. LEADERSHIP ROLES Croarkin PE, Nakonezny PA, Husain MM, Port JD, Melton T, Kennard BD, Emslie GJ, Kozel FA, Daskalakis ZJ. Evidence for pretreatment LICI deficits among depressed children and adolescents with nonresponse to fluoxetine. Brain Stimul 2014;7(2):243-51. Shirlene M. Sampson, M.D., Executive Committee Member, International Society for ECT and Neurostimulation, 2010 – present. Paul Croarkin, D.O. Co-Chair of Annual Meeting, Clinical Society of Transcranial Magnetic Stimulation, 2014-2015. Dare FY, Rasmussen KG. Court-approved electroconvulsive therapy in patients unable to provider their own consent: A case series. J ECT 2014 (epub ahead of print). 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 7 Pediatric Anxiety Disorders Research Group INVESTIGATORS Stephen P. Whiteside, Ph.D., L.P., Bridget K. Biggs, Ph.D., L.P., Mark W. Olsen, M.D., Michael S. Tiede, MA, LP, and Julie E. Dammann, MA, LP From left to right: Dammann, Whiteside, Biggs, Tiede The goal of this multidisciplinary research team is to improve the care of children and adolescents with anxiety disorders and obsessive compulsive disorder (OCD). During the past year, we completed a dismantling study evaluating the relative effectiveness of different components of CBT and an examination of anxiety treatment throughout the Mayo Clinic Health System. We are currently investigating the potential for using technology to increase access to high quality treatment for childhood anxiety disorders. This work proceeds under a grant to develop a web-based application for clinicians to interact with patients using our iPhone application, Mayo Clinic Anxiety Coach, and a grant to develop an immersive video game for children with social phobia. Our team is also in the process of extending our research on intensive treatments for pediatric OCD to all pediatric anxiety disorders. Finally, we are continuing work to develop an electronic assessment system for evaluating pediatric psychiatric symptoms. In 2014 - 2015 presentations and workshops were given at the annual meetings of the World Congress of Cognitive and Behavioral Therapy, the Anxiety and Depression Association of America, and the Association of Behavioral and Cognitive Therapy. GRANT KEY PUBLICATIONS National Institute of Mental Health Clinic: Expanding access to CBT for childhood anxiety disorders via smart phones (R34 MH 100468). Funding period: 2013-2016; PI: Whiteside. Ale, C. M., Arnold, E.A., Whiteside, S. P., & Storch, E. A. (2014). Family-based behavioral treatment of pediatric compulsive hoarding: A case example. Clinical Case Studies, 13, 9-21. National Institute of Mental Health Clinic: Games for Children with Social Anxieties (SBIR MH 103301). Funding period: 20142016; Site-PI: Whiteside. Gryczkowski M.R., Tiede M.S., Dammann J.E., Brown Jacobsen A., Hale L.R., & Whiteside S.P. (2013). The Timing of Exposure in Clinic-Based Treatment for Childhood Anxiety Disorders. Behavior Modification, 37, 211-225. McKay, D. & Whiteside S.P. (2013). Introduction to the special issue: New methods in exposure therapy. Behavior Modification, 37, 163-169. Nogueira, C. Y. S., Carvalho, A. M., Gauer, G. Tavares, N, Santos, R. M. M., Ginani, G., Rivero, T. S., Moraes, P. H. P., Whiteside, S. P., Malloy-­Diniz, L. F. (2013). Translation and adaptation of impulsive behavior scale (UPPS) to the Brazilian population. Clinical Neuropsychiatry, 10, 79-­85. 6 8 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY CLINICAL DISORDERS Whiteside, S. P., Ale, C. M., Vickers Douglas, K., Tiede, M. S., & Dammann, J. E. (2014). Case examples of enhancing pediatric OCD treatment with a smartphone application. Clinical Case Studies, 13, 80-94. Whiteside, S. P., Gryczkowski, M., Ale, C. M., Brown-Jacobsen, A. M., McCarthy, D. M. (2013). Development of child- and parentreport measures of behavioral avoidance related to childhood anxiety disorders. Behavior Therapy, 44, 325-337. Whiteside, S. P., McKay, D., De Nadai, A. S., Tiede, M.S., Ale, C. M., & Storch, E. A. (in press). A baseline controlled examination of a 5-day intensive treatment for pediatric obsessive-compulsive. Psychiatry Research. Young, B. J., Wallace, D. P., Imig, M., Borgerding, L., BrownJacobsen, A. M., & Whiteside, S. P. (2013). Parenting behaviors and childhood anxiety: A psychometric investigation of the EMBU-C. Journal of Child and Family Studies, 22, 1138-1146. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 9 Rochester Epidemiologic Psychiatric Research Program INVESTIGATORS William V. Bobo, M.D. and J. Michael Bostwick, M.D. William V. Bobo, M.D. J. Michael Bostwick, M.D. The suicide research group focuses on improving suicide risk assessment and management through identifying risk factors and warning signs in high-risk clinical groups. Dr. Bostwick continues to supervise numerous residents and medical students, mentoring promising trainees as they undertake suicidology research projects. Using an Olmsted County cohort of more than 1,500 suicide attempters who received medical care after their attempts, Dr. Bostwick is investigating what proportion eventually died by suicide and what characterizes the long-term survivors compared to the dead. He leads a case-control study looking at health care visits and suicidal ideation in the year prior to completed suicide (86 cases) with the goals of identifying whether decedents had more visits than controls and whether they said or did anything during those visits that implicated future risk. He is participating in a naturalistic study looking at outcomes in more than 200 patients who have overdosed on acetaminophen, a readily available but potentially lethal over-the-counter medication. Dr. Bostwick is also involved in ongoing projects on physician suicide, transjurisdictional suicide, suicide in patients hospitalized on medical or surgical units, and the role of the Dexamethasone Suppression Test as a suicide risk indicator, using historical and current cohorts. KEY PUBLICATIONS Bailey CH, Andersen LK, Lowe GC, Pittelkow MR, Bostwick JM , Davis MD. A population-based study of the incidence of delusional infestation in Olmsted County, Minnesota, 1976-2010. Br J Dermatol. 2014 May; 170(5):1130-5. PMID:24472115. DOI:10.1111/bjd.12848. Foster AA, Hylwa SA, Bury JE, Davis MD, Pittelkow MR, Bostwick JM . Delusional infestation: clinical presentation in 147 patients seen at Mayo Clinic. J Am Acad Dermatol. 2012 Oct; 67(4):673.e1-10. Epub 2012 Jan 20. PMID:22264448. DOI:10.1016/j.jaad.2011.12.012. Shekunov J, Geske JR, Bostwick JM . Inpatient medical-surgical suicidal behavior: a 12-year case-control study. Gen Hosp Psychiatry. 2013 Jul-Aug; 35(4):423-6. Epub 2013 Apr 15. PMID:23597876. DOI:10.1016/j.genhosppsych.2013.03.005. 6 10 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY CLINICAL DISORDERS Samuel C. Johnson Genomics of Addiction Program INVESTIGATORS Joanna M. Biernacka, Ph.D., Doo-Sup Choi, Ph.D., Mark A. Frye, M.D., Daniel K. HallFlavin, M.D., Victor M. Karpyak, M.D., Ph.D., Paul E. Croarkin, D.O., Keith D. Robertson, Ph.D., Terry D. Schneekloth, M.D., Marin Vedic, M.D., and Richard Weinshilboum, M.D. Back row, from left to right: Schneekloth, Karpyak, Hall-Flavin, Bobo Front row: Choi, Frye The Samuel C. Johnson Genomics of Addiction Program was designed to bring a multidisciplinary, integrated group of clinicians and scientists together to work synergistically to better understand how genetic vulnerability is related to the onset and treatment of alcohol use disorders. In addition, this multidisciplinary research team has concentrated on developing individualized molecular strategies for alcoholism treatment, with the primary focus on studying the pharmacogenomics of anti-craving medications. The S.C. Johnson research team was awarded a P20 developmental center grant from the National Institute on Alcohol Abuse and Alcoholism to establish the Center for Individualized Treatment of Alcohol Dependence (CITA). The primary goal of the funded research was to develop infrastructure for an expanding research team dedicated to designing and launching systematic pharmacogenomic and imaging studies of pharmacological treatments for alcoholism, initially focused on the medication acamprosate, an FDA-approved medication for treating alcoholism. The grant has funded the creation of an expanded multidisciplinary team of investigators who work together to design and conduct preclinical and clinical studies to identify which alcohol-dependent patients are most likely to benefit from acamprosate. With the successful implementation of the National Institutes of Health-supported P20 Center, Mayo S.C. Johnson investigators have published more than 110 peer-reviewed articles in major journals during the last three years in the field of addiction, neuroscience, genetics, and psychiatry. With future support from the NIH and benefactors this multidisciplinary research team plans to expand its studies to better understand the best individualized treatments for alcoholism. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 11 GRANTS KEY PUBLICATIONS National Institute of Alcohol Abuse and Alcoholism (R01): Alcohol and Adenosine-Mediated Glutamate Signaling in Neuro-Glial Interaction. Funding period: 09/2009 – 08/2015; PI: Choi. Abulseoud OA, Camsari UM, Mohamed K, Abdel Gawd N, Ruby CL, Kasasbeh A, Yuksel MY, Choi DS. Lateral hypothalamic kindling induces manic-like behaviors in rats. Intl. J. Bipolar Dis. In Press, 2014. National Institute of Alcohol Abuse and Alcoholism (R01): Developmental pathways, environmental agents, and epigenetics in liver disease. Funding period: 09/2011 – 08/2016; PI K Robertson. S. C. Johnson Genomics of Addiction: Biomarker Development for Individualized Treatment of Alcoholism. Funding period: 01//2014 – 12/2017; PI: Choi. Department of Psychiatry and Psychology Research Grant: Orexin Signaling Mediates Ethanol Drinking Behavior in the Lateral Hypothalamic Kindled Female Rat Mania Model, the Impact of Pregnancy. Funding period: 04/2014 – 04/2016; PI: Choi. Abulseoud OA, Camsari UM, Ruby CL, Kasasbeh A, Choi S, Choi DS. Attenuation of ethanol withdrawal by ceftriaxoneinduced upregulation of glutamate transporter EAAT2. Neuropsychopharmacol. 39: 1674-1684, 2014. Bobo WV, Pathak J, Kremers HM, Yawn BP, Brue SM, Stoppel CJ, Croarkin PE, St Sauver J, Frye MA, Rocca WA. An electronic health record driven algorithm to identify incident antidepressant medication users. J. Am. Med. Inform Assoc. In Press, 2014. Mayo-KI Collaborative Grant: Glutamate NMDA Receptor Signaling in Schizophrenia Disorders. Funding period: 03/2014 – 12/2014; PI: Choi. Chopra A, Abulseoud OA, Sampson S, Lee KH, Klassen BT, Fields JA, Matsumoto JY, Adams AC, Stoppel CJ, Geske JR, Frye MA. Mood Stability in Parkinson Disease Following Deep Brain Stimulation: A 6-Month Prospective Follow-up Study. Psychosomatics. In Press, 2014. Mayo-KI Collaborative Grant: Mathematical Neuroendocrine Modeling of the Lateral Hypothalamic Kindled Rat. Funding period: 03/01/2014 – 12/01/2014; PI: Abulseoud. Co-I: Choi Croarkin P, Thomas MA, Port JD, Baruth J, Choi DS, Abulseoud, OA, Frye MA. N-acetylaspartate normalization in bipolar depression after lamotrigine treatment. Bipolar Dis. In Press, 2014. Mayo Clinic Center for Individualized Medicine Award: Epigenetic DNA Methylation in Bipolar Disorders. Funding period: 08/2012 – 07/2015; PI: Veldic. Cuellar-Barboza AB, Frye, MA. Grothe K, Prieto ML, Schneekloth TD, Loukianova LL, Hall-Flavin DK, Clark MM, Karpyak VM, Miller JD, Abulseoud OA. Change in consumption patterns for treatmentseeking patients with alcohol use disorder post bariatric surgery. J Psychosom Res 2014 in press. Department of Psychiatry and Psychology Research Grant: Epigenetic Regulation of the Expression of Metabotropic Glutamate Receptors (mGluR2 and mGlur3) in Patients with Bipolar Disorder and without Comorbid Alcohol Use Disorder. Funding period: 01/2014 – 12/2014; PI: Veldic, Co-PI: Blacker Marriott Foundation: Bipolar Biobank Biomarker Development (3BD) Program. Funding period: 01/13 – 12/17; PI: Frye, Co-PI: Biernacka, Co-I: Choi National Institute of Mental Health (K23): Glutamate Probes in Adolescent Depression. Funding period: 02/14 – 01/18; PI: Croarkin Brain and Behavior Research Foundation: Glutamate Neurotransmission in Depressed Adolescents at Risk for Bipolar Disorder. Funding period: 07/14 – 06/16; PI: Croarkin Mayo Clinic Center for Individualized Medicine Award: Genetic variation in the glycine signaling and metabolic pathways as a pharmacogenetic predictor of treatment response to acamprosate. 04/2012-04/2013; PI: Karpyak 6 12 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY Frye MA, Prieto ML, Bobo WV, Kung S, Veldic M, Alarcon RD, Moore KM, Choi DS, Biernacka JM, Tye SJ. Current landscape and unmet needs for treatment of bipolar depression (Review). J. Affect Dis. In Press, 2014. Grothe KB1, Mundi MS, Himes SM, Sarr MG, Clark MM, Geske JR, Kalsy SA, Frye MA. Bipolar Disorder Symptoms in Patients Seeking Bariatric Surgery. Obes Surg. In Press, 2014. Hinton DJ, Lee MR, Jang JS, Choi DS. ENT1 regulates glial fibrillary acidic protein expression in the striatum. Brain and Behavior. 4:903914, 2014. Hinton DJ, Lee MR, Kwong HK, Blanco MC, Choi DS. Aberrant bone density in the spine of aged mice lacking adenosine transporter ENT1. PLoS One. 9:288818, 2014. Hlady RH, Tiedemann RL, Puszyk W, Zendejas I, Roberts RL, Choi J-H, Liu C, Robertson KD. Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis. Oncotarget. 5:9425-43, 2014. Karpyak VM, Biernacka J, Geske JR, Jenkins D, Cunningham JM, Ruegg J, Kononenko O, Leontovich AA, Abulseoud O, Hall-Flavin D, Loukianova LL, Schneekloth TD, Skime M, Frank J, Nothen MM, Rietschel M, Kiefer F, Mann K, Weinshilboum RM, Frye MA, Choi DS. Genetic markers associated with abstinence length in alcohol dependent subjects treated with acamprosate. Translational Psychiatry. 4:e462, 2014. Karpyak VM, Romanowicz M, Schmidt JE, Lewis KA, Bostwick JM. Characteristics of heart rate variability in alcohol-dependent subjects and nondependent chronic alcohol users. Alcohol Clin. Exp. Res. 38:926, 2014. Karpyak VM, Winham SJ, Biernacka JM, Cunningham JM, Lewis KA, Geske JR, Colby CL, Abulseoud OA, Hall-Flavin DK, Loukianova LL, Schneekloth TD, Frye MA, Heit JA, Mrazek DA. Association of GATA4 sequence variation with alcohol dependence. Addict Biol. 19:312-5, 2014. Kolla BP, Schneekloth T, Biernacka J, Mansukhani M, Geske J, Karpyak V, Hall-Flavin D, Loukianova L, Frye MA. The course of sleep disturbances in early alcohol recovery: an observational cohort study. Am. J. Addict. 23:21-6, 2014. Lindberg D, Shan D, Ayers-Ringler J, Oliveros A, Benitez J, Prieto Cancino M, McCullumsmith R, Choi DS. Purinergic signaling and energy homeostasis in mental illness. Curr. Mol. Med. In Press, 2014. Mrazek DA, Biernacka JM, McAlpine DE, Benitez J, Karpyak VM, Williams MD, Hall-Flavin DK, Netzel PJ, Passov V, Rohland BM, Shinozaki G, Hoberg AA, Snyder KA, Drews MS, Skime MK, Sagen JA, Schaid DJ, Weinshilboum RM, Katzelnick DJ. Treatment Outcomes of Depression: The Pharmacogenomic Research Network Antidepressant Medication Pharmacogenomic Study. J Clin Psychopharmacol. In Press, 2014. Pathak J, Simon G, Li D, Biernacka JM, Jenkins G, Chute C, HallFlavin D, Weinshilboum R. Detecting associations between major depressive disorder treatment, essential hypertension using electronic health records. Accepted for publication. 2014. Post RM, Altshuler LL, Leverich GS, Frye MA, Suppes T, McElroy SL, Keck PE Jr, Nolen WA, Kupka RW, Grunze H, Rowe M. More medical comorbidities in patients with bipolar disorder from the United States than from the Netherlands and Germany. J. Nerv. Ment. Dis. 202:26570, 2014. Prieto ML, Cuéllar-Barboza AB, Bobo WV, Roger VL, Bellivier F, Leboyer M, West CP, Frye MA. Risk of myocardial infarction and stroke in bipolar disorder: a systematic review and exploratory metaanalysis. Acta Psychiatr. Scand. In Press, 2014. Ruby CL, Vadnie CA, Hinton, DJ, Abulseoud OA, Walker DL, O’Connor K, Noterman, MF, Choi DS. Adenosinergic Regulation of Striatal Clock Gene Expression and Ethanol Intake During Constant Light. Neuropsychopharmacol. 39:2432-2440, 2014. Stamm TJ, Lewitzka U, Sauer C, Pilhatsch M, Smolka MN, Koeberle U, Adli M, Ricken R, Scherk H, Frye MA, Juckel G, Assion HJ, Gitlin M, Whybrow PC, Bauer M. Supraphysiologic doses of levothyroxine as adjunctive therapy in bipolar depression: a randomized, double-blind, placebo-controlled study. J. Clin. Psychiatry. 75:162-8, 2014. Vadnie C, Hinton D, Choi S, Choi Y, Ruby C, Oliveros A, Prieto M, Park JH, Choi DS. Activation of neurotensin receptor type 1 attenuates locomotor activity. Neuropharmacol. 85: 482-492, 2014. Vadnie C, Park JH, Abdel-Gawad N, Ho ADC, Hinton, DA, Choi DS. Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders (Review). Frontiers Neurosci. 8:288:1-25, 2014. Watanabe H, Fitting S, Hussain MZ, Kononenko O, Iatsyshyna A, Yoshitake T, Kehr J, Alkass K, Druid H, Wadensten H, Andren PE, Nylander I, Wedell DH, Krishtal O, Hauser KF, Nyberg F, Karpyak VM, Yakovleva T, Bakalkin G. Asymmetry of the Endogenous Opioid System in the Human Anterior Cingulate: a Putative Molecular Basis for Lateralization of Emotions and Pain. Cereb Cortex. In Press, 2014. Winham SJ, Barboza AC, McElroy S, Oliveros A, Crow S, Colin LC, Choi DS, Chauhan M, Frye M, Biernacka JM. Bipolar disorders with comorbid binge eating history: A genome-wide association study implicates APO. J. Affective Disorders. 165:151-158, 2014. Winham SJ, Barboza AC, Oliveros A, McElroy S, Crow S, Colby C, Choi DS, Chauhan M, Frye M, Biernacka JM. Genome-wide association study of bipolar disorders accounting for effect of body mass index identifies a new risk allele in TCF7L2. Mol. Psychiatry. 19:1010-1016, 2014. Post RM, Altshuler L, Kupka R, McElroy S, Frye MA, Rowe M, Leverich GS, Grunze H, Suppes T, Keck PE Jr, Nolen WA. More pernicious course of bipolar disorder in the United States than in many European countries: implications for policy and treatment. J. Affect. Disord. 160:27-33, 2014. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 13 CLINICAL DISORDERS Ji Y, Schaid DJ, Desta Z, Kubo M, Batzler AJ, Snyder K, Mushiroda T, Kamatani N, Ogbyrn E, Hall-Flavin D, Flockhart D, Nakamura T, Mrazek DA, Weinshilboum RM. Citalopram and escitalopram drug and metabolite concentrations: genome-wide associations. Br J Clin Pharmacol. 2014 Aug; 78(2):373-83. PMCID: 24528284. PMCID: 4137829. DOI:10.1111/bcp.12348. Individualized Medicine Biobank for Bipolar Disorder INVESTIGATORS Mark A. Frye, M.D., Joanna M. Biernacka, Ph.D, Christine W. Galardy, M.D., Ph.D., Simon Kung, M.D., Teresa A. Rummans, M.D., Bruce Sutor, M.D., Marin Veldic, M.D., Paul E. Croarkin, D.O., William V. Bobo, M.D., Susannah J. Tye, Ph.D., Doo-Sup Choi, Ph.D., Stacey J. Winham, Ph.D., (Rochester, Minnesota) and Elliott Richelson, M.D. (Jacksonville, Florida) Back row, left to right: Biernacka, Bobo, Frye, Choi, Winham Front row, left to right: Nassan, Veldic, Seymour Researchers in this team are establishing a large-scale biobank for bipolar type I disorder, collecting both biological samples and clinical data from 2,000 individuals. This is a multisite endeavor, with Mayo Clinic in Rochester, Minnesota, serving as the primary project site. Other sites that will assist in the recruitment of participants include Mayo Clinic in Jacksonville, Florida, Mayo Clinic in Scottsdale, Arizona, Austin Medical Center–Mayo Health System (Austin, Minnesota), the Lindner Center of HOPE (Mason, Ohio), and the University of Minnesota. By establishing the infrastructure of this data-rich biobank, researchers hope to facilitate studies on disease risk and pharmacogenomic probes using state-of-the-art research technology. The identification of genetic risk factors associated with disease onset can potentially lead to early interventional treatment in at-risk patients. This early intervention is particularly important in bipolar disorder because the initiation of any treatment for bipolar disorder is often delayed by more than a decade from the time of onset. Additionally, identification of pharmacogenomic predictors of treatment response could provide increased selectivity to treatment recommendations, as well as help prevent such serious adverse events as antidepressant-induced mania. 6 14 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY GRANT KEY PUBLICATIONS ACADEMIC CAREER DEVELOPMENT Croarkin PE, Thomas MA, Port JD, Baruth J, Choi D-S, Abulseoud OA, Frye MA. N-acetylaspartate normalization in bipolar depression after lamotrigine treatment. Bipolar Disord 2014 in press. Mark A. Frye, M.D. Scientific Reviewer. Member, NIMH Interventions Committee for Adult Disorders (ITVA) 2013 – Present. Frye MA, McElroy SL, Prieto ML, Harper KL, Kung S, Chauhan M, Crow S, Sutor B, Galardy CW, Veldic M, Palmer BA, Geske JR, Fuentes M, Cuellar-Barboza AB, Seymour LR, Mori N, Biernacka JM. Clinical risk factors and serotonin transporter gene variants associated with antidepressant-induced mania. J Clin Psychiatry 2014 in press. Grothe KB, Mundi MS, Himes SM, Sarr MG, Clark MM, Geske JR, Kalsy SA, Frye MA. Bipolar disorder symptoms in patients seeking bariatric surgery. Obes Surg 2014 in press. Prieto ML, Cuellar Barboza AB, Bobo WV, Roger VL, Bellievier F, Leboyer M, West CP, Frye MA. Systematic review and metaanalysis of myocardial infarction and stroke risk in bipolar disorder: Implications for clinical practice and prevention. Acta Psychiatr Scand 2014 in press. PROFESSIONAL INTERNATIONAL PRESENTATIONS World Psychiatric Association’s XVI World Congress of Psychiatry September 14-18, 2014, Madrid Spain Symposium Chair: Cardiovascular Disease and Obesity in Bipolar Disorder: Translational Research Focused on Epidemiology and Genetics, “Mayo Clinic Bipolar Biobank: Focus on Metabolic Disorders”. International Society of Bipolar Disorder August 22, 2014, Medellin, Colombia Plenary Session. “Bipolar Disorder: Think Global – Treat Local” Prieto ML, Youngstrom EA, Ozerdem A, Altinbas K, Quiroz D, Aydemir O, Yalin N, Geske JR, Feeder S, Angst J, and Frye MA. Different Patterns of Manic / Hypomanic Symptoms in Depression: a Pilot Modification of the Hypomania Checklist – 32 to Assess Mixed Depression. J Affective Disorders 2014, in press. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 15 NOVEL ME THODS FOR UNDERSTANDING Mayo Clinic with a Generous Gift from the Marriott Family Mayo Clinic Individualized Medicine Biobank for Bipolar Disorder Frye/Biernacka (Co-PIs) 12/2008 – 12/2012 Winham SJ, Cuellar-Barboza AB, McElroy SL, Oliveros A, Crow S, Colby CL, Choi D-S, Chauhan M, Frye MA, Biernacka JM. Bipolar disorder with comorbid binge eating history: A genome-wide association study implicates ApoB. J Affect Disord 2014 Aug; 165: 151-158. Doi: 10.1016/j.jad.2014.04.026.Epub 2014 Apr 19. Psychiatric Pharmacogenomics And Pharmacometabolomics of Antidepressant Therapy INVESTIGATORS Richard Weinshilboum, M.D., Liewei Wang, M.D., Ph.D., Kurt B. Angstman, M.D., Joanna M. Biernacka, Ph.D., Meenal Gupta, Ph.D., Daniel K. Hall-Flavin, M.D., Astrid A. Hoberg, R.N., C.N.S., Yuan Ji, Ph.D., David J. Katzelnick, M.D., Balmiki Ray, MBBS, Barbara M. Rohland, M.D., Daniel J. Schaid, Ph.D., Karla A. Schroder, R.N., C.N.S., and Jeffrey P. Staab, M.D. Back row, left to right: Chai, Skime, Ray, Hofschulte Front row: Weinshilboum, Wang The primary objective of this research program is to better understand genetic variability as it relates to antidepressant response. This program has been supported since 2005 by a grant from the National Institute of General Medical Sciences (NIGMS) as part of the NIH Pharmacogenomics Research Network (PGRN), and over 800 Mayo patients with major depressive disorder (MDD) treated with citalopram or escitalopram have been studied. A second arm of this study involved the use of a serotoninnorepinephrine reuptake inhibitor, duloxetine, in patients who did not respond when treated with escitalopram or citalopram. In addition, this program also organized an International SSRI Pharmacogenomics Consortium (ISPC) that included samples from approximately 1000 SSRI-treated MDD patients. In 2010, the RIKEN Institute in Japan conducted a genome-wide association study (GWAS) of an initial PGRN patient cohort of 521 patients, and during the past year, RIKEN also performed a GWAS for the ISPC samples. Left to right: Karpyak, Bobo, Frye A new area of research that our team has recently undertaken involves the use of induced pluripotent stem (iPS) cells. Under the leadership of Dr. Yuan Ji, the PGRN team received funding from the University of Minnesota–Mayo Clinic partnership to study iPS cell-derived neurons from MDD patients treated with SSRIs. Our team partnered with Timothy J. Nelson, MD, PhD, at Mayo Clinic, with colleagues at the University of Minnesota and with the Salk Institute for Biological Studies in California to study iPS cell-derived neurons from a subset of patients who had participated in the PGRN SSRI study. Finally, a pharmacometabolomic study of escitalopram and citalopram response in the PGRN MDD patients has been completed that has identified novel biomarkers that provide insight into both variation in antidepressant therapy response and the pathophysiology of MDD. 6 16 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY GRANTS National Institute of General Medical Sciences (R01): Inherited Variations in Drug Metabolizing Enzymes. Funding period: 06/01/12 – 3/31/16; PI: Weinshilboum. Minnesota Partnership for Biotechnology and Medical Genomics. Funding Period 1/01/211- 1/31/2015; PIs: Ji and Weinshilboum. KEY PUBLICATIONS Abo, R., Hebbring, S., Ji, Y., Zhu, H., Zeng, Z.B., Batzler, A., Jenkins, G.D., Biernacka, J., Snyder, K., Drews, M., Fiehn, O., Fridley, B., Schaid, D., Kamatani, N., Nakamura, Y., Kubo, M., Mushiroda, T., Kaddurah-Daouk, R., Mrazek, D.A. and Weinshilboum, R.M.: Merging pharmacometabolomics with pharmacogenomics using “1000 Genomes” SNP imputation: selective serotonin reuptake inhibitor response pharmacogenomics. Pharmacogenet Genomics 22(4):247-253, 2012. PMID: 22322242; PMCID: PMC3303952 Ellsworth, K., Moon, I., Eckloff, B.W., Fridley, B.L., Jenkins, G.D., Batzler, A., Biernacka, J., Abo, R., Brisbin, A., Ji, Y., Hebbring, S., Wieben, E.D., Mrazek, D.A., Weinshilboum, R.M. and Wang, L. FKBP5 genetic variation: association with SSRI treatment outcomes in major depressive disorder. Pharmacogenet Genomics. 2013 Mar;23(3):156-66. doi: 10.1097/FPC.0b013e32835dc133. PubMed PMID: 23324805; PMCID: PMC3784025. Ji, Y., Biernacka, J.M., Hebbring, S., Chai, Y., Jenkins, G.D., Batzler, A., Snyder, K.A., Drews, M.S., Desta, Z., Flockhart, D., Mushiroda, T., Kubo, M., Nakamura, Y., Kamatani, N., Schaid, D., Weinshilboum, R.M. and Mrazek, D.A.: Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: genome-wide associations and functional genomics. Pharmacogenomics J. 2012 Aug 21. 13(5):456-63. doi: 10.1038/tpj.2012.32. [Epub ahead of print] PubMed PMID: 22907730; PMCID: PMC3941038. Ji, Y., Biernacka, J., Snyder, K., Drews, M., Pelleymounter, L.L., Colby, C., Wang, L., Mrazek, D.A. and Weinshilboum, R.M.: Catechol O-methyltransferase pharmacogenomics and selective serotonin reuptake inhibitor response. The Pharmacogenomics J. 12:78-85, 2012 [Epub ahead of print 2010 Sep 28.]. PMID: 20877297; PMCID: PMC3138818 Mrazek, D., Biernacka, J.M., McAlpine, D.E., Benitez, J., Karpyak, V.M., Williams, M.D., Hall-Flavin, D.K., Netzel, P.J., Passov, V., Rohland, B.M., Shinozaki, G., Hoberg, A.A., Snyder, K.A., Drews, M.S., Skime, M.K., Sagen, J.A., Schaid, D.J., Weinshilboum, R. and Katzelnick, D.J. Treatment outcomes of depression: the pharmacogenomic research network antidepressant medication pharmacogenomic study. J Clin Psychopharmacol. 2014 Jun;34(3):313-7. PubMed PMID: 24743713; PubMed Central PMCID: PMC3992481 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 17 NOVEL ME THODS FOR UNDERSTANDING National Institute of General Medical Sciences (U19): Pharmacogenetics of Phase 2 Drug Metabolizing Enzymes— Pharmacogenomic Clinical Study Core. Funding period: 07/2010 – 06/2015; PI: Weinshilboum. Pharmacokinetics and Pharmacodynamics of SSRIs. Ji, Y., Schaid, D.J., Desta, Z., Kubo, M., Batzler, A., Snyder, K., Mushiroda, T., Kamatani, N., Ogburn, E., Hall-Flavin, D., Flockhart, D., Nakamura, Y., Mrazek, D. and Weinshilboum, R.M. Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations. Br J Clin Pharmacol. 2014 Aug;78(2):373-83. doi: 10.1111/bcp.12348. PubMed PMID: 24528284; PubMed Central PMCID: PMC4137829. Translational Neuroscience Laboratory INVESTIGATORS Susannah J. Tye, Ph.D., Doo-Sup Choi, Ph.D., Joanna M. Biernacka Ph.D., Victor M. Karpyak, M.D., Ph.D., Marin Veldic, M.D., Paul E. Croarkin, D.O., Shari L. Sutor MA, and Mark A. Frye, M.D. Back row, from left to right: Choi, Tye, Croarkin, Sutor, Frye, Veldic Front row: Abulseoud, Karpyak, Biernacka Our Translational Neuroscience Laboratory provides the space and expertise for members of the Department of Psychiatry & Psychology to conduct cutting-edge research in translational neuroscience, genomic psychiatry, and biomarker discovery using the latest cellular, molecular, and genetic technologies. Biomarker discovery has already had an immense impact upon the prevention and treatment of many diseases, but remains in its relative infancy in psychiatry. Our research combines multiple scientific approaches to bring new insight into the causes of psychiatric illness and factors mediating individual treatment outcomes. Our ‘bench to bedside’ and ‘back to bench’ framework is helping us to better understand the interplay between genetic and environmental risk factors so that we can provide more targeted treatments for patients. Recent research projects have focused on defining the role of genetic and environmental factors in depression, bipolar disorder, and alcoholism. In combination with our focused search for biomarkers of treatment response, the outcomes of this research will enable us to individualize patient care and tailor treatments in ways not previously possible. In addition to this, our facility functions as a classroom for trainees and faculty in psychiatry and psychology who are interested in learning how to do preclinical and bench-top research. Several of these individuals have gone on to develop their own research careers in of psychiatric genetics, epigenetics, biomarker development and preclinical modeling. GRANTS Brain and Behavior Research Foundation, NARSAD Young Investigator Award. Glutamatergic Neurotransmission in Youth at Risk for Bipolar Disorder. (PI: Croarkin, Mentor: Frye) 07/2013 – 07/2015. MINH Mentored Patient-Orientated Research Career Development Award 1K23MH10026-01A1, Glutamate Probes in Adolescent Depression. (PI: Croarkin, Mentor: Frye) 02/2013 – 01/2018. 6 18 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY Abulseoud OA, Miller JD, Wu J, Choi DS, Holschneider DP. Ceftriaxone upregulates the glutamate transporter in medial prefrontal cortex and blocks reinstatement of methamphetamine seeking in a condition place preference paradigm. Brain Res. 2012; 1456: 14-21. Anderson RJ, Frye MA, Abulseoud OA, Lee KH, McGillivray J, Berk M, Tye SJ. Deep Brain Stimulation for Treatment-Resistant Depression: Efficacy and Mechanisms of Action. Neurosci Biobehav Rev, 2012; 36(8): 1920-1933. Biernacka JM, McElroy SL, Crow S, Sharp A, Benitez J, Veldic M, Kung S, Post RM, Mrazek D, Frye MA. Pharmacogenomics of Antidepressant Induced Mania: Meta-Analysis of the Serotonin Transporter Gene (5HTTLPR). J Affect Disord. 2012; 136(1-2): e21-29. Karpyak VM, Geske JR, Colby CL, Mrazek DA, Biernacka JM. Genetic variability in the NMDA-dependent AMPA trafficking cascade is associated with alcohol dependence. Addict Biol. 2012; 17(4): 798-806. Karpyak VM, Winham SJ, Preuss UW, Zill P, Cunningham JM, Walker DL, Lewis KA, Geske JR, Colby CL, Abulseoud OA, HallFlavin DK, Loukianova LL, Schneekloth TD, Frye MA, Bazov I, Heit JA, Bakalkin G, Mrazek DA, Biernacka JM. Association of the PDYN gene with alcohol dependence and the propensity to drink in negative emotional states. Int J Neuropsychopharmacol. 2012; 1-11. Lee MR, Ruby CL, Hinton DJ, Choi S, Adams CA, Young Kang N, Choi DS. Striatal adenosine signaling regulates EAAT2 and astrocytic AQP4 expression and alcohol drinking in mice. Neuropsychopharmcology. 2013; 38(3): 437-445. Li X, Frye MA, Shelton RC. Review of Pharmacological Treatment in Mood Disorders and Future Directions for Drug Development. Neuropsychopharmacology 2012; 37(1): 77-101. Nam HW, McIver SR, Hinton DJ, Thakkar MM, Sari Y, Parkinson FE, Haydon PG, Choi DS. Adenosine and glutamate signaling in neuron-glial interactions: implications in alcoholism and sleep disorders. Alcohol Clin Exp Res. 2012; 36(7): 1117-1125. Walker AJ, Burnett SA, Hasebe K, McGillivray JA, Gray L, McGee SL, Walder K, Berk M, Tye SJ. Chronic adrenocorticotrophic hormone treatment alters tricyclic antidepressant efficacy and prefrontal monoamine tissue levels. Behav Brain Res. 2013; 242: 76–83. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 19 NOVEL ME THODS FOR UNDERSTANDING KEY PUBLICATIONS Brain Rehabilitation Research Group INVESTIGATORS Thomas F. Bergquist, Ph.D., L.P. and Allen W. Brown, M.D. Back row, left to right: Moessner, Brown, Bergquist, Kendall Front row, left to right: Mitchell, Dernbach, King The brain rehabilitation research group is composed of a multidisciplinary team with members from the departments of nursing, physical medicine, rehabilitation, neurology, social services, and psychiatry and psychology. Our Center has been continuously funded by the National Institute on Disability and Rehabilitation Research (NIDRR) as a Traumatic Brain Injury Model System (TBIMS) Center, contributing subjects to the TBIMS national database (the largest non-proprietary longitudinal dataset of outcomes for individuals who receive inpatient rehabilitation after TBI, now with greater than 13,000 subjects) and involved in collaborative analyses of this dataset. Current site-specific research includes a community-based randomized pragmatic clinical trial in four upper Midwest states, testing whether a remotely provided coordinated care model improves outcome after TBI compared to a matched group receiving usual care in their communities. Internal collaborators for this study include the Center for Innovation and Center for Social Media. External collaborators include the Departments of Health in Minnesota and Iowa and Trinity and Regional Health systems in the Dakotas. Additional collaborative biotechnology research includes the development of a smartphone-based system to improve transportation access for the cognitively impaired (NIH, with Koronis Biomedical Technologies Corp.) and testing of a low-cost neurocognitive rehabilitation system (NIDRR, with Advanced Medical Electronics Corp.). Internal collaborative work includes the use of shear wave ultrasound elastography to study muscle stiffens after stroke. Current collaborative research projects between Mayo Clinic’s TBIMS Center and other funded centers (a total of 16 nationally) include study of internet use among individuals with TBI and an investigation of their resilience. Mayo’s Brain Rehabilitation Research group networks with academic institutions and agencies that do similar research including regional Departments of Health, Human Services, and Vocational Rehabilitation; the Brain Injury Alliances of Iowa, Minnesota and Wisconsin and surrounding states, and regional VA medical centers. 6 20 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY GRANTS KEY PUBLICATIONS National Institute on Disability and Rehabilitation Research (NIDRR): Department of Education (H133A070013). Mayo Clinic TBI Model System Center. Funding period: 10/2012 – 09/2017. PI: Brown. Bergquist TF, Micklewright JL, Yutsis M, Smigielski JS, Gehl C, Brown AW. Achievement of client-centered goals by persons with acquired brain injury in comprehensive day treatment is associated with improved functional outcomes. Brain Inj. 2012; 26(11):1307-14. Mayo Clinic Small Grant Program. The Epidemiology of Traumatic Brain Injury in Olmsted County, MN 1985-1999. Funding period: 10/23/2013 - 10/22/2015. PI: Brown. Brown AW, Watanabe TK, Hoffman JM, Bell KR, Lucas S, Dikmen S. Headache After Traumatic Brain Injury: A National Survey of Clinical Practices and Treatment Approaches. PM R. 2014 Jul 11. [Epub ahead of print] National Institutes of Health. System to Improve Transportation Access for the Cognitively Impaired (R43 HD70828). Funding period: 06/2012 - 02/2014. PI: Brown. National Institute on Disability and Rehabilitation Research (NIDRR): Department of Education (H133S130047). Low-Cost Neurocognitive Rehabilitation System for Traumatic Brain Injury. Funding period: 11/2013 - 03/2014. PI: Brown. Brown AW, Leibson CL, Mandrekar J, Ransom JE, Malec JF. Longterm survival after traumatic brain injury: a population-based analysis controlled for nonhead trauma. J Head Trauma Rehabil. 2014 Jan-Feb; 29(1):E1-8. Davis, L., Sherer, M., Sander, A., Bogner, J., Corrigan, J., Dilkers, M., Hanks, R., Bergquist, T. & Seel, R. Pre-injury predictors of life satisfaction at one year after traumatic brain injury. Archives of Physical Medicine and Rehabilitation 2012; 93(8):1324-1330. Forducey, P., Gluekauf, R., Bergquist, T., Maheu, M., Yutsis, M.. Telehealth for persons with severe functional disabilities and their caregivers: Facilitating self-care management in the home setting. Psychological Services, 2012; 9(2):144-62. Walker WC, Marwitz JH, Wilk AR, Ketchum JM, Hoffman JM, Brown AW, Lucas S. Prediction of headache severity (density and functional impact) after traumatic brain injury: A longitudinal multicenter study. Cephalalgia. 2013 Sep; 33(12):998-1008. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 21 NOVEL ME THODS FOR INTERVENING Yutsis M, Bergquist T, Micklewright J, Gehl C, Smigielski J, Brown AW. Pre-treatment compensation use is a stronger correlate of measures of activity limitations than cognitive impairment. Brain Inj. 2012; 26(11):1297-306. The Pain Rehabilitation Center Research Group INVESTIGATORS Karen E. Weiss, Ph.D., L.P., Jeannie A. Sperry, Ph.D., L.P., Barbara K. Bruce, Ph.D., L.P., Tracy E. Harrison, M.D., Cynthia Harbeck-Weber, Ph.D., L.P., Larissa L. Loukianova, M.D., Ph.D, Julie M. Cunningham, Pharm.D., R.Ph., Marin Veldic, M.D., and Leslie A. Sim, Ph.D., L.P. Mayo Clinic Florida and Mayo Clinic Rochester Left to right: Harbeck-Weber, Cunningham, Weiss, Veldic, Harrison, Loukianova, Sperry We are excited to report that during the past year the Pain Rehabilitation Center Program (PRC) has experienced several major transitions that have resulted in our research team expanding. While our primary research efforts continue to focus on measurement of adult clinical outcomes, we have also been collaborating with faculty outside of PRC and increasing our research efforts in our pediatric program. Specifically, Dr. Jeannie Sperry is interested in physician education regarding evidenced-based chronic pain assessment and treatment, Dr. Cynthia Harbeck-Weber will be examining effects of biofeedback on pain management, and our pediatric research team is examining the nature of anxiety in adolescents with chronic pain and POTS. Dr. Larissa Loukianova is examining factors that relate to outcomes in PRC for patients who have had a hysterectomy and Dr. Tracy Harrison will be examining medication tapers within the pediatric PRC. We have been working with Dr. Leslie Sim on the prevalence of eating disorders in youth with pain and POTS (Postural Orthostatic Tachycardia Syndrome). Dr. Marin Veldic is conducting a pilot study to examine changes in biomarkers for patients who complete PRC. Finally, Dr. Karen Weiss is collaborating with Dr. Emily Law at Seattle Children’s Hospital on a pilot study examining effects of a parent intervention focused on problem-solving skills. Research team members are from all disciplines of our team including anesthesiology, psychology, psychiatry, physical therapy, occupational therapy, nursing, and recreational therapy have been presenting PRC data at regional, national and international conferences. GRANTS Mayo Medical School and Mayo Clinic Department of Psychiatry and Psychology. Grant from Mayo’s OASES Endowment for Educational Research Award (EERA) for “Assessment of Integrated Knowledge, Skill, and Attitudes Regarding Assessing and Treating AntidepressantInduced Sexual Side Effects”. Co-Principle Investigator: Jeannie A. Sperry, Ph.D. (2014) Consultant for West Virginia Family Medicine Foundation grant from Claude Worthington Benedum Foundation to develop a replicable model for treating chronic pain while reducing prescription drug abuse. Study will include assessment of changes in prescribing practices, referral rates for behavioral problems and substance use, implementation of evidence-based practices for chronic pain, and morbidity and mortality associated with medication misuse. Jeannie A. Sperry, Ph.D. (2014-2017) Seattle Children’s Hospital Internal Grant. Co-investigator Karen E. Weiss, Ph.D. (2014-2015) 6 22 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY KEY PUBLICATIONS Cunningham, JL. Opioid Induced Hyperalgesia: A focus on Opioid use in chronic pain. Ment. Health Clin. 2013;2(12):36. Fiske A, Bamonti PM, Nadorff MR, Petts RA, Sperry J. (2013) Control Strategies and Suicidal Ideation in Older Primary Care Patients with Functional Limitations. International Journal of Psychiatry in Medicine 46(3) 269-287. Formea CM, Nicholson WT, McCullough KB, Berg KD, Berg ML, Cunningham JL, Merten JA, Ou NN, Stollings JL. Development and evaluation of a pharmacogenomics educational program for pharmacists. Am J Pharm Educ 2013; 77 (1) Article 9 Harrison, T. E., Bruce, B. K., Weiss, K. E., Rummans, T. A., & Bostwick, M. (2013). Marijuana and chronic nonmalignant pain in adolescents. Mayo Clinic Proceedings, 88, 647-650. Pestka, E, Nash V, Evans M, Cronin J, Bee S, King S, Osborn K, Gehin J, Weis K, Loukianova L. (in press) Assessment of Family History of Substance Abuse for Preventive Interventions with Patients Experiencing Chronic Pain: A Quality Improvement Project. International Journal of Nursing Practice. Schmidt ST, Lapid MI, Sundsted KK, Cunningham JL, Ryan DA, Burton MC. Safety of Electroconvulsive Therapy in Patients Receiving Dabigatran Therapy. Psychosomatics 2014; Jul Aug; 55(4):400-403. Tseng, A. S., Weiss, K. E., Harrison, T., Hansen, D., & Bruce, B. (2014). Pain relief as a primary treatment goal: At what point does functioning and well-being become more important? A case study of an adolescent with debilitating chronic pain. Pain Research and Management, 19, 219-223. NOVEL ME THODS FOR INTERVENING Kizilbash, S. J., Ahrens, S. P., Bruce, B. K., Chelimsky, G., Driscoll, S. W., Harbeck Weber, C., Lloyd, R.M., Mack, K.J., Nelson, D.E., Ninis, N., Pianosi, P.T., Stewart, J.M., Weiss, K. E., Fischer, P. R. (2014). Adolescent fatigue, POTS, and recovery: A guide for clinicians. Current Problems in Pediatric and Adolescent Health Care, 44, 107134. Pestka EL, Nash VR. Genetic aspects of migraine headaches. Nurse Pract. 2013 May10;38(5):12-3. Weiss, K. E., Hahn, A., Wallace, D. P., Biggs, B., Bruce, B. K., & Harrison, T. E. (2013). Acceptance of pain: Associations with depression, catastrophizing, and functional disability among children and adolescents in a multidisciplinary chronic pain rehabilitation program. Journal of Pediatric Psychology. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 23 Psychosomatic Research Group INVESTIGATORS Jeffrey P. Staab, M.D., MS, Richard J. Seime, Ph.D., L.P., Shawna L. Ehlers, Ph.D., L.P., Shirlene M. Sampson, M.D., (Rochester, MN) Cynthia M. Stonnington, M.D., Kari A. Martin, M.D., Lois E. Krahn, M.D. (Scottsdale, AZ) Left to right: Ehlers, Seime, Staab Krahn, Stonnington The Psychosomatic Research Group investigates problems at the interface between medical and psychiatric illnesses. Many of the investigators on this team work in the multidisciplinary Behavioral Medicine Program. Research areas of investigation include functional disorders in multiple medical specialties (e.g., behavioral spells, chronic dizziness, functional movement disorders, functional gastrointestinal tract disorders); somatic symptom disorders and illness anxiety; psycho-oncology; psychiatric morbidity in medically ill patients; and predictors of disability and health care utilization. Our research collaborations, funding, and publications have an international reach. 6 24 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY Cousins S, Cutfield NJ, Kaski D, Palla A, Seemungal BM, Golding JF, Staab JP, Bronstein AM. Visual dependency and dizziness after Co-Principal Investigator: Staab vestibular neuritis. PLoS One. 2014; 9(9):e105426. 7/2014-6/2019 A Phase II Trial on Rizatriptan for Vestibular Migraine Ehlers SL , Bronars CA, Patten CA, Brockman T, Hughes C, Funding: National Institute on Deafness and Other Communicative Decker PA, Cerhan JR, Hogan W, Dispenzieri A, Ansell S, Ebbert Disorders, U01 DC013256-01 A1 J, Gastineau D. Accuracy of self-reported tobacco use status among hematopoietic SCT patients. Bone Marrow Transplant. 2014 Jul; Co-Investigator: Ehlers 49(7):961-5. 1/2014 – 12/2016 Testing a Computerized Interactive Stress Management Chopra A, Abulseoud OA, Sampson S, Lee KH, Klassen BT, Intervention in Early Stage Cancer: A Randomized Controlled Trial Fields JA, Matsumoto JY, Adams AC, Stoppel CJ, Geske JR, Funding: The Norwegian Cancer Society (Kreftforeningen) # Frye MA. Mood stability in Parkinson disease following deep 4602492 brain stimulation: a 6-month prospective follow-up study. Psychosomatics. 2014 Sep-Oct;55(5):478-84. Principal Investigator: Staab 4/2012-12/2014 Indovina I, Riccelli R, Staab JP, Lacquaniti F, Passamonti L. Pharmacologic Dissection of Vestibular Migraine and Chronic Personality traits modulate subcortical and cortical vestibular and Subjective Dizziness Funding: Mayo Clinic Scholarly Opportunity anxiety responses to sound-evoked otolithic receptor stimulation. Award and Department of Psychiatry and Psychology J Psychosom Res. 2014 Sep 16. pii: S0022-3999(14)00326-2. doi: 10.1016/j.jpsychores.2014.09.005. [Epub ahead of print]. Carlson ML, Tveiten OV, Driscoll CL, Neff BA, Shepard NT, Eggers Co-Investigator: Staab SD, Staab JP, Tombers NM, Goplen FK, Lund-Johansen M, Link 9/2012-8/2014 MJ. Long-term Dizziness Handicap in Patients with Vestibular The Role of Acceptance in Adjustment to Meniere’s Disease Schwannoma: A Multicenter Cross-sectional Study. Otolaryngol Funding: Meniere’s Society of the United Kingdom Head Neck Surg. 2014 Oct 1. pii: 0194599814551132. [Epub ahead of print]. Principal Investigator: Staab 9/2013-8/2014 Tatpati LL, Hudson SBA, Ehlers SL, Coddington CC. Impact of A Multidimensional Psychological Construct of Somatic Symptom closure of fertility services on patients’ emotional well-being: The Disorders psychological impact of reduced access to care. 2014; J Reprod Med. Funding: Mayo Clinic Small Grant Program, Department of (in press). Psychiatry and Psychology Rausch Osian S, Leal A, Allmer C, Maurer M, Nowakowski G, Co-Investigator: Staab Inwards G, Macon W, Ehlers SL, Link BK, Habermann TM, Cerhan 9/2013-8/2014 JR, Thompson CA. Widespread Use of Complementary and A Pilot Project to Investigate the Use of an External Vestibular Alternative Medicine (CAM) amongst Non-Hodgkin Lymphoma Prosthesis: Potential to Improve Clinical Management of Chronic (NHL) Survivors. Leukemia and Lymphoma (in press). Subjective Dizziness (CSD) Funding: Mayo Clinic Small Grant Program, Department of Otorhinolaryngology AWARDS AND LEADERSHIP ROLES KEY PUBLICATIONS Richard J. Seime, PhD, Acting President and President Elect, American Board of Clinical Health Psychology. Stonnington CM , Locke DE, Hsu CH, Ritenbaugh C, Lane RD. Somatization is associated with deficits in affective Theory of Mind. J Psychosom Res. 2013 Jun; 74(6):479-85. Shawna L. Ehlers, PhD, Program Chair Elect (2015), Program Chair (2016), American Psychological Association Health Psychology Locke DEC, Dueck AC, Stonnington CM , Knopman DS, Geda YE, Caselli RJ. Depressive Symptoms in Healthy APOE e4 Carriers and Noncarriers: A Longitudinal Study. J Clin Psychiatry. 2013 Dec;74(12):1256-61. Jeffrey P. Staab, MD, MS, Chair, Behavioral Subcommittee of the Classification Committee of the Barany Society Staab JP, Rohe DE, Eggers SD, Shepard NT. Anxious, introverted personality traits in patients with chronic subjective dizziness. J Psychosom Res. 2014 Jan; 76(1):80-3. Staab JP. The influence of anxiety on ocular motor control and gaze. Curr Opin Neurol. 2014 Feb; 27(1):118-24. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 25 MEDICAL DISE ASES INTERFACE WITH PSYCHIATRY & PSYCHOLOGY GRANTS Cancer and Quality of Life INVESTIGATORS Matthew M. Clark, Ph.D., Simon Kung, M.D., Maria I. Lapid, M.D., and Jarrett W. Richardson, M.D., (Rochester, MN) Teresa A. Rummans, M.D., Steven C. Ames, Ph.D., and Shehzad K. Niazi, M.D. (Jacksonville, FL) From left to right: Richardson, Clark, Kung, Lapid The primary goal of the cancer research team is to improve the quality of life for cancer patients and their caregivers by first assessing and treating psychiatric difficulties and then teaching skills for coping with cancer. This multidisciplinary research team spans the Jacksonville, Florida, and Rochester, Minnesota, Mayo Clinic campuses. The team is involved in several externally funded research projects that seek to identify the predictors of quality of life for cancer survivors or that evaluate tailored multidisciplinary interventions designed to improve the quality of life of cancer survivors and their caregivers. Rummans, Ames GRANTS Linse Bock Foundation: Improving Quality of Life of Cancer Caregivers: An Internet Based Intervention. Funding period: 01/2012 – 12/2016; Co-PIs: Lapid, Clark, Rummans. Linse Bock Foundation: A Structured Multidisciplinary Intervention to Improve Quality of Life of Patients Receiving Active Oncological Treatment: A Randomized Trial. Funding period: 03/2004 – 02/2015; Co-PIs: Clark, Rummans. National Cancer Institute: Health and Quality of Life among LongTerm Lung Cancer Survivors. Funding period: 07/2006 – 11/2014; PI: Yang (Cancer Center, Epidemiology), co-investigator: Clark. 6 26 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY ACOSOG Community Clinical Oncology Program (CCOP) Research Base. Funded by the National Cancer Center. Funding period: 08/2011- 08/2016; Co-investigators: Clark, Lapid, Rummans. Examining Reasons for Breast Cancer Disparities in African American Women in Duval County, FL. Funded by Office of Health Disparities Research. 01/01/2014 – 152/31/2014. A computerized interactive stress management intervention in early stage cancer: A randomized controlled trial. The Norwegian Cancer Society; co-investigator: Clark Arnold ML, Thiel DD, Diehl N, Wu KJ, Ames S , Parker AS. Comparison of baseline quality of life measures between renal cell carcinoma patients undergoing partial versus radical nephrectomy. BMC Urol. 2013; 13:52. Epub 2013 Oct 22. PMID:24148752. PMCID:3816591. DOI:10.1186/1471-2490-13-52. Chock MM, Lapid MI, Atherton PJ, Kung S, Sloan JA, Richardson JW, Clark MM, Rummans TA. Impact of a structured multidisciplinary intervention on quality of life of older adults with advanced cancer. Int Psychogeriatr. 2013 Dec; 25(12):2077-86. Epub 2013 Sep 04. PMID:24001635. DOI:10.1017/S1041610213001452. Clark MM , Atherton PJ, Lapid MI, Rausch SM, Frost MH, Cheville AL, Hanson JM, Garces YI, Brown PD, Sloan JA, Richardson JW, Piderman KM, Rummans TA. Caregivers of patients with cancer fatigue: a high level of symptom burden. Am J Hosp Palliat Care. 2014 Mar; 31(2):121-5. Epub 2013 Feb 21. PMID:23434836. DOI:10.1177/1049909113479153. Clark MM , Rummans TA, Atherton PJ, Cheville AL, Johnson ME, Frost MH, Miller JJ, Sloan JA, Graszer KM, Haas JG, Hanson JM, Garces YI, Piderman KM, Lapid MI, Netzel PJ, Richardson JW, Brown PD. Randomized controlled trial of maintaining quality of life during radiotherapy for advanced cancer. Cancer. 2013 Feb 15; 119(4):880-7. Epub 2012 Aug 28. PMID:22930253. DOI:10.1002/ cncr.27776. Frost MH, Novotny PJ, Johnson ME, Clark MM , Sloan JA, Yang P. Spiritual well-being in lung cancer survivors. Support Care Cancer. 2013 Jul; 21(7):1939-46. Epub 2013 Feb 19. PMID:23420557. PMCID:3669652. DOI:10.1007/s00520-013-1757-z. Hu C, Kung S, Rummans TA, Clark MM , Lapid MI. Reducing caregiver stress with internet-based interventions: a systematic review of open-label and randomized controlled trials. J Am Med Inform Assoc. 2014 Aug 14. PMID:25125686. DOI:10.1136/ amiajnl-2014-002817. Lapid MI, Atherton PJ, Kung S, Cheville AL, McNiven M, Sloan JA, Clark MM , Rummans TA. Does gender influence outcomes from a multidisciplinary intervention for quality of life designed for patients with advanced cancer? Support Care Cancer. 2013 Sep; 21(9):2485-90. Epub 2013 Apr 23. PMID:23609927. DOI:10.1007/ s00520-013-1825-4. Piderman KM, Johnson ME, Frost MH, Atherton PJ, Satele DV, Clark MM , Lapid MI, Sloan JA, Rummans TA. Spiritual quality of life in advanced cancer patients receiving radiation therapy. Psychooncology. 2014 Feb; 23(2):216-21. Epub 2013 Sep 9 PMID:24019196. DOI:10.1002/pon.3390. Shahi V, Lapid MI, Kung S, Atherton PJ, Sloan JA, Clark MM , Rummans TA. Do age and quality of life of patients with cancer influence quality of life of the caregiver? J Geriatr Oncol. 2014 Jul; 5(3):331-6. Epub 2014 Apr 14. PMID:24726867. DOI:10.1016/j. jgo.2014.03.003. Tavlarides AM, Ames SC , Diehl NN, Joseph RW, Castle EP, Thiel DD, Broderick GA, Parker AS. Evaluation of the association of prostate cancer-specific anxiety with sexual function, depression and cancer aggressiveness in men 1 year following surgical treatment for localized prostate cancer. Psychooncology. 2013 Jun; 22(6):1328-35. Epub 2012 Aug 01. PMID:22855322. DOI:10.1002/ pon.3138. Tavlarides AM, Ames SC , Thiel DD, Diehl NN, Parker AS. Baseline and follow-up association of the MAX-PC in Men with newly diagnosed prostate cancer. Psychooncology. 2014 Jun 21. PMID:24953309. DOI:10.1002/pon.3605. NATIONAL MEMBERSHIPS National Comprehensive Cancer Network; Distress Management Panel. Dr. Clark 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 27 MEDICAL DISE ASES INTERFACE WITH PSYCHIATRY & PSYCHOLOGY KEY PUBLICATIONS Neuropsychology, Aging, and Cognition Adult Investigators: Back row: Ivnik, Bergquist Front row, left to right: Machulda, Trenerry, Cerhan, Smith, Fields Florida group: From left to right: Rush, Ferman, Lucas, Pedraza 6 28 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY Child Investigators: From left to right: Huebner, Brown, Zaccariello Arizona group: From left to right: Krell-Roesch, Locke, Stonnington, Geda, Pink Thomas F. Bergquist, Ph.D., L.P., Jane H. Cerhan, Ph.D., L.P., Julie A. Fields, Ph.D., L.P., Robert J. Ivnik, Ph.D., L.P., Mary M. Machulda, Ph.D., L.P., Daniel E. Rohe, Ph.D., L.P., Jeffrey S. Smigielski, Ph.D., L.P., Glenn E. Smith, Ph.D., L.P., Max R. Trenerry, Ph.D., L.P. (Rochester, Minnesota) Melanie C. Chandler, Ph.D., Tanis J. Ferman, Ph.D., John A. Lucas, Ph.D., Otto Pedraza, Ph.D., Beth K. Rush, Ph.D. (Jacksonville, Florida) Yonas E. Geda, M.D., Kristin A. Kirlin, Ph.D., Dona E. Locke, Ph.D., David Osborne, Ph.D., Cynthia M. Stonnington, M.D., Jennifer V. Wethe, Ph.D. (Scottsdale, Arizona) PEDIATRIC INVESTIGATORS Tanya M. Brown, Ph.D., L.P., Andrea R. S. Huebner, Ph.D., L.P., Michael J. Zaccariello, Ph.D., L.P. The aging and cognition research group focuses on factors associated with normal and pathological aging. They strongly embrace a multidisciplinary team approach within and among all three Mayo sites, which has afforded them the opportunity to participate in cutting-edge research examining risk factors, progression, and treatment outcomes in neurodegenerative and acquired neurologic disorders. This group collaborates with colleagues in behavioral neurology, neuropsychiatry, neuroimaging, neuropathology, molecular biology, and pharmacology as well as with other investigators at Mayo Clinic and other institutions. The Mayo Clinic Study of Aging, the Alzheimer’s disease Research Center, the TBI Model Systems, and the Centers of Excellence for Parkinson’s Disease are among Mayo’s most multidisciplinary and translational research programs. Group members have identified imaging and cognitive biomarkers for a wide range of dementing illnesses, such as Alzheimer’s disease, Lewy body dementia, frontotemporal dementia, speech and language-based dementias, and amyotrophic lateral sclerosis. They have developed clinical tools, neuropsychological norms (including African American norms), and functional neuroimaging strategies that in combination have helped increase the diagnostic and prognostic accuracy of assessments. Additionally, investigators on these teams are showing that behavioral interventions and brain rehabilitation techniques can mitigate cognitive deficits and improve functional outcomes in mild cognitive impairment and traumatic brain injury. They are also examining outcomes of treatments such as deep brain stimulation for movement and psychiatric disorders, and aerobic exercise in Alzheimer’s disease, and pursuing novel assessment strategies such as computer and mobile-assisted evaluations. The pediatric investigators are focused on developing 1) evidenced-based approaches to neuropsychological assessment, 2) algorithms that reliably assess change across time and 3) effective interventions for children and adolescents who have had a traumatic brain injury. They are also exploring cognition in Niemann-Pick Disease, multiple sclerosis, and the neurodevelopment of children exposed to anesthesia. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 29 MEDICAL DISE ASES INTERFACE WITH PSYCHIATRY & PSYCHOLOGY ADULT INVESTIGATORS GRANTS ALS Association: Discovery and Validation of ALS Biomarkers. Funding period: 08/2013 – 07/2014; Co-Investigator: Pedraza. Alzheimer’s Association: Amyloid-related imaging abnormalities (microbleeds) in atypical AD. Funding period: 11/2012 – 04/2015; Co-Investigator: Machulda. Arizona Department of Health Services: Normal and Pathological Aging (Preclinical Alzheimer ’s disease. Funding period: 7/2011 – 06/2016; Co-Investigators: Geda, Locke, Stonnington. Boston Scientific Neuromodulation Corporation: INTREPID – Implantable Neurostimulator for the Treatment of Parkinson’s Disease. Funding period: 09/2014 – 08/2019; Co-Investigators: Fields, Lucas. Brains Together for a Cure: Impact of Apolipoprotein E Genotype on Baseline Neurocognition and Radiation-Induced Neurocognitive Dysfunction in Patients with Brain Tumors. Funding period: 09/2013 – 08/2014; Principal Investigator: Cerhan. Center for Individualized Medicine, Mayo Clinic: The Cognitive Effects of Lorazepam in Healthy Older Individuals with TOMM40 Variable-Length Polymorphisms. Funding period: 01/2013 – 01/2015; Principal Investigator: Stonnington. National Institute on Aging/State of Arizona: Arizona Alzheimer’s Disease Core Center. Funding period: 12/2005 – 6/2015; CoInvestigator: Locke. National Institute on Aging: Education and Information Transfer Core, Mayo Alzheimer’s Disease Research Center. Funding period: 05/2014 – 04/2019; Principal Investigator: Lucas. National Institute on Aging: Normal and Pathological Aging. Funding period: 12/2005 – 6/2015; Co-Investigator: Locke. National Institute on Aging: Core B: ADCC Clinical Core in: Alzheimer’s Disease Core Center, Cores A, B and C. Funding period: 08/2011 - 06/2016; Co-Investigator: Locke. National Institute on Aging: Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS). Funding period: 09/2014 – 05/2019; Co-Investigator: Fields. National Institute on Aging: Mayo Clinic Alzheimer’s Disease Research Center. Funding period: 05/2014 – 04/2019; CoInvestigators: Ferman, Fields, Geda, Ivnik, Lucas, Machulda, Pedraza, Smith. National Institute on Aging: Mayo Clinic Olmsted Study of Aging/ Alzheimer’s Disease Patient Registry. Funding period: 07/14 – 06/2019; Co-Investigators: Fields, Geda, Ivnik, Machulda. Center for Innovation, Mayo Clinic: Development of a Mobile, Computerized, Cognitive Screening Exam. Funding period: 01/2014 – 12/2014; Principal Investigator: Pedraza, Co-Investigator: Lucas. National Institute on Aging: Sex-specific Risk for Vascular Dysfunction and Cognitive Decline. Funding period: 09/2012 08/2017; Co-Investigator: Fields. Department of Defense: Cortical Lesions as Determinants of White Matter Lesion Formation and Cognitive Abnormalities in MS. Funding period: 05/2103 – 04/2015; Co-Investigator: Rohe. National Institute on Deafness and Other Communication Disorders: Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech. Funding period: 07/2013 – 06/2018; CoInvestigator: Machulda. Mangurian Foundation for Lewy Body Research. Funding period: 02/2011 – 01/2015; Co-Investigators: Ferman, Pedraza. National Cancer Institute: ACOSOG Community Clinical Oncology Program (CCOP) Research Base. Funding period: 08/2011 – 05/2016; Co-Investigator: Cerhan. National Institute of Neurological Disorders and Stroke: LDN: Niemann-Pick Disease, Type C in: LDN: Longitudinal Study of Cognition in Subjects with Niemann-Pick Disease, Type C. Funding period: 09/2009 - 08/2014; Co-Investigators: Brown, Zaccariello. National Institute of Neurological Disorders and Stroke: PET, APOE, & the Preclinical Course of Alzheimer Disease. Funding period: 05/2014 – 04/2019. Co-Investigator: Locke. 6 30 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY National Institute on Deafness and Other Communication Disorders: PIB PET Scanning in Speech and Language-Based Dementias. Funding period: 02/2010 - 01/2015; Co-Investigator: Machulda. National Institute on Disability and Rehabilitation Research: Department of Education, Mayo Clinic TBI Model Systems Center. Funding period: 10/2012 – 09/2017; Co-Investigator: Bergquist. National Institutes of Health: Aerobic Exercise in Alzheimer’s Disease: Cognition and Hippocampal Volume Effects (The FIT-AD Trial). Funding period: 08/2013 – 07/2018; Principal Investigator: Smith. National Institutes of Health: Pathobiology of Neurodegeneration in C9ORF72 Repeat Expansion. Funding period: 10/2014 – 09/2019; Co-Investigators: Pedraza, Rush. National Institutes of Health: Phase III Intergroup Study of Radiotherapy versus Temozolomide Alone versus Radiotherapy with Concomitant and Adjuvant Temozolomide for Patients with 1p/19q Codeleted Anaplastic Glioma. Funding period: 06/2010 – 06/2014; Co-Investigator: Cerhan. cognitive impairment, and Alzheimer’s disease. Neurobiology of Aging, EPub Aug 04. Caselli RJ, Locke DEC, Dueck AC, Knopman DS, Woodruff BK, Hoffman Snyder C, Rademakers R, Fleisher AS, Reiman EM. (2014). The neuropsychology of normal aging and preclinical Alzheimer’s disease. Alzheimer’s & Dementia, 10, 84-92. National Institutes of Health: Neurodevelopment of Children Exposed to Anesthesia: A Population-Based Assessment. Funding period: 04/2012 - 03/2017; Co-Investigator: Zaccariello. Chopra A, Abulseoud OA, Sampson S, Lee KH, Klassen BT, Fields JA, Matsumoto JY, Adams AC, Stoppel CJ, Geske JR, Frye MA. (2014). Mood stability in Parkinson disease following deep brain stimulation: a 6-month prospective follow-up study. Psychosomatics 55(5):478-84. Neuroscience Focused Research Team, Mayo Clinic: Development of a Computerized Screening Exam. Funding period: 10/2014 – 12/2014; Principal Investigator: Pedraza. Conant LL, Wilfong A, Inglese C, Schwarte (Huebner) A. (in press). Dysfunction of executive and related processes in childhood absence epilepsy. Epilepsy and Behavior. St. Anne’s University Hospital: Neuroepidemiology – Aging, Pre-Clinical Alzheimer’s Disease and Dementia. Funding period: 1/2011 – 12/2015; Principal Investigator: Geda; Co-Investigator: Locke. Croarkin PE, Nakonezny PA, Lewis CP, Zaccariello MJ , Huxsahl JE, Husain MM, Kennard BD, Emslie GJ, Daskalakis ZJ. (2014). Developmental aspects of cortical excitability and inhibition in depressed and healthy youth: an exploratory study. Frontiers in Human Neuroscience, Epub Sep 02. KEY PUBLICATIONS Adeli A, Savica R, Lowe VJ, Vemuri P, Knopman DS, DejesusHernandez M, Rademakers R, Fields JA, Crum BA, Jack CR, Petersen RC, Boeve BF. (2014). The GGGGCC repeat expansion in C9ORF72 in a case with discordant clinical and FDG-PET findings: PET trumps syndrome. Neurocase 20(1):110-20. Bergquist TF, Yutsis M, Micklewright J. (2014). Comprehensive assessment. In Sherer, M., Sander, A; (Eds.). Handbook on the Neuropsychology of Traumatic Brain Injury. New York, NY: Springer. Bondi MW, Smith GE. (2014). Mild cognitive impairment: a concept and diagnostic entity in need of input from neuropsychology. Journal of the International Neuropsychological Society 20(2):12934. Canon A, Bieniek KF, Lin WL, Notari S, Zou WQ, Gambetti P, Pedraza O, Graff-Radford NR, Ferman TJ, Dickson DW. (2014). Concurrent variably protease sensitive prionopathy and amyotrophic lateral sclerosis. Acta Neuropathologica 128(2):313315. Carrasquillo MM, Crook JE, Pedraza O, Thomas CS, Pankratz VS, Allen M, Nguyen T, Malphrus KG, Ma L, Bisceglio GD, Roberts RO, Lucas JA, Smith GE, Ivnik RJ, Machulda MM , Graff-Radford NR, Petersen RC, Younkin SG, Ertekin-Taner N. (2014). Lateonset Alzheimer’s risk variants in memory decline, incident mild Ferman TJ, Smith GE, Dickson DW, Graff-Radford NR, Lin SC, Wszolek Z, Van Gerpen JA, Uitti R, Knopman DS, Petersen RC, Parisi J, Silber MH, Boeve BF. (in press). Abnormal daytime sleepiness in dementia with Lewy bodies compared to Alzheimer’s disease using the Multiple Sleep Latency Test. Alzheimer’s Research and Therapy. Geda YE , Roberts RO, Mielke MM, Knopman DS, Christianson TJH, Pankratz VS, Boeve BF, Sochor O, Tangalos EG, Petersen RC, Rocca WA. (2014). Baseline neuropsychiatric symptoms and the risk of incident mild cognitive impairment: A population-based study. American Journal of Psychiatry 171(5):572-81. Graff-Radford J, Murray ME, Lowe VJ, Boeve BF, Ferman TJ, Przybelski SA, Lesnick TG, Senjem ML, Gunter JL, Smith GE, Knopman DS, Jack CR Jr, Dickson DW, Petersen RC, Kantarci K. (2014). Dementia with Lewy bodies: basis of cingulate island sign. Neurology 83(9):801-9. Josephs K, Whitwell J, Weigand S, Murray M, Tosakulwong N, Liesinger A, Petrucelli L, Knopman D, Boeve B, Ivnik R, Smith G, Jack C, Parisi J, Petersen R, Dickson D. (2014). Tdp-43 influences cognition, memory loss and hippocampal atrophy in Alzheimer’s disease. Journal of Neuropathology & Experimental Neurology 73(6):587-8. Josephs KA, Duffy JR, Strand EA, Machulda MM , Senjem ML, Gunter JL, Schwarz CG, Reid RI, Spychalla AJ, Lowe VJ, Jack CR Jr, Whitwell JL. (2014). The evolution of primary progressive apraxia of speech. Brain 137(Pt 10):2783-95. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 31 Josephs KA, Whitwell JL, Weigand SD, Murray ME, Tosakulwong N, Liesinger AM, Petrucelli L, Senjem ML, Knopman DS, Boeve BF, Ivnik RJ, Smith GE, Jack CR Jr, Parisi JE, Petersen RC, Dickson DW. (2014). TDP-43 is a key player in the clinical features associated with Alzheimer’s disease. Acta Neuropathologica 127(6):811-24. Roberts RO, Knopman DS, Cha RH, Mielke MM, Pankratz VS, Boeve BF, Kantarci K, Geda YE, Jack CR Jr, Petersen RC, Lowe VJ. (2014). Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation. Journal of Nuclear Medicine 55(5):759-64. Karver CL, Wade SL, Cassedy A, Taylor HG, Brown TM, Kirkwood MW, Stancin T. (2014). Cognitive reserve as a moderator of responsiveness to an online problem-solving intervention for adolescents with complicated mild-to-severe traumatic brain injury. Child Neuropsychology 20(3):343-57. Roberts RO, Knopman DS, Mielke MM, Cha RH, Pankratz VS, Christianson TJ, Geda YE, Boeve BF, Ivnik RJ, Tangalos EG, Rocca WA, Petersen RC. (2014). Higher risk of progression to dementia in mild cognitive impairment cases who revert to normal. Neurology Jan 28; 82(4):317-25. Kirlin KA, Locke DEC (2014). The role of neuropsychology on an epilepsy monitoring unit: A peek behind the “do not disturb” sign. The Neurodiagnostic Journal 54 (3), 289-298. Shi J, Stonnington CM, Thompson PM, Chen K, Gutman B, Reschke C, Baxter LC, Reiman EM, Caselli RJ, Wang Y for the Alzheimer’s Disease Neuroimaging Initiative (2014). Studying ventricular abnormalities in mild cognitive impairment with hyperbolic Ricci flow and tensor-based morphometry. Neuroimage, EPub Oct 5. Knopman DS, Roberts RO, Pankratz VS, Cha RH, Rocca WA, Mielke MM, Boeve BF, Tangalos EG, Ivnik RJ, Geda YE, Petersen RC. (2014). Incidence of dementia among participants and nonparticipants in a longitudinal study of cognitive aging. American Journal of Epidemiology 180(4):414-23. Lageman, SK, Brown, PD, Anderson, SK, Lachance, DH, Yan, E, Laack, N, Cerhan, JH, (2014). Exploring primary brain tumor patient caregiver needs and preferences in brief educational and support opportunities. Supportive Care in Cancer, EPub Sept 14. Lee RW, Hoogs MM, Burkholder DB, Trenerry MR, Drazkowski JF, Shih JJ, Doll KE, Tatum WO 4th, Cascino GD, Marsh WR, Wirrell EC, Worrell GA, So EL. (2014). Outcome of intracranial electroencephalography monitoring and surgery in magnetic resonance imaging-negative temporal lobe epilepsy. Epilepsy Research 108(5):937-44. Lucas, JA, Mahone, EM, Westerveld, M, Bieliauskas, L, & Baron, IS. (2014). The American Board of Clinical Neuropsychology and American Academy of Clinical Neuropsychology: Updated Milestones from 2005-2014. The Clinical Neuropsychologist 28(6):889-906. Mielke MM, Savica R, Wiste HJ, Weigand SD, Vemuri P, Knopman DS, Lowe VJ, Roberts RO, Machulda MM, Geda YE, Petersen RC, Jack CR Jr. (2014). Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study. Neurology 82(1):70-6. Nedelska Z, Ferman TJ, Boeve BF, Przybelski SA, Lesnick TG, Murray ME, Gunter JL, Senjem ML, Vemuri P, Smith GE, Geda YE, Graff-Radford J, Knopman DS, Petersen RC, Parisi JE, Dickson DW, Jack CR Jr, Kantarci K. (2014). Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies. Neurobiology of Aging, EPub Jul 15. Pedraza O, Allen M, Jennette K, Carrasquillo M, Crook J, Serie D, Pankratz VS, Palusak R, Nguyen T, Malphrus K, Ma L, Bisceglio G, Roberts RO, Lucas JA, Ivnik RJ, Smith GE, Graff-Radford NR, Petersen RC, Younkin SG, Ertekin-Taner N. (2014). Evaluation of memory endophenotypes for association with CLU, CR1, and PICALM variants in black and white subjects. Alzheimer’s & Dementia 10(2):205-13. 6 32 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY Staab JP, Rohe DE, Eggers SD, Shepard NT. (2014). Anxious, introverted personality traits in patients with chronic subjective dizziness. Journal of Psychosomatic Research 76(1):80-3. Stonnington CM, Chen K, Lee W, Locke DEC, Dueck AC, Liu X, Roontiva A, Fleisher AS, Caselli RJ, Reiman EM. (2014). Fibrillar amyloid correlates of preclinical cognitive decline. Alzheimer’s & Dementia, 10, e1-8. Vemuri P, Lesnick TG, Przybelski SA, Machulda M, Knopman DS, Mielke MM, Roberts RO, Geda YE, Rocca WA, Petersen RC, Jack CR Jr. (2014). Association of lifetime intellectual enrichment with cognitive decline in the older population. JAMA Neurology 71(8):1017-24. Wade SL, Karver CL, Taylor HG, Cassedy A, Stancin T, Kirkwood MW, Brown TM. (2014). Counselor-assisted problem solving improves caregiver efficacy following adolescent brain injury. Rehabilitation Psychology 59(1):1-9. Wade SL, Stancin T, Kirkwood M, Brown TM, McMullen KM, Taylor HG. (2014). Counselor-Assisted Problem Solving (CAPS) improves behavioral outcomes in older adolescents with complicated mild to severe TBI. Journal of Head Trauma and Rehabilitation 29(3):198-207. Wershba R, Locke DEC, Lanyon R (in press). Analysis of Minnesota Multiphasic Personality Inventory-2-Restructured Form response bias indicators as suppressors or moderators in a medical setting. Psychological Assessment. Zhang B, Ferman TJ, Boeve BF, Smith GE, Maroney-Smith M, Spychalla AJ, Knopman DS, Jack CR Jr, Petersen RC, Kantarci K. (2014). MRS in mild cognitive impairment: early differentiation of dementia with Lewy bodies and Alzheimer’s disease. J Neuroimaging, EPub Jul 15. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 33 The HABIT (Healthy Actions to Benefit Independence and ThinkingTM) Clinical Research Program INVESTIGATORS Glenn E. Smith Ph.D., L.P., Julie A. Fields Ph.D., L.P., Sherrie M. Hanna, M.A., L.P., Angela M. Lunde M.A. (Rochester, Minnesota) Melanie J. Chandler, Ph.D., Miranda Morris, M.A., Francine C. Parfitt, M.A. (Jacksonville, Florida) Dona E. Locke Ph.D., Andrea V. Cuc, L.C.S.W., Jeanne C. Young (Scottsdale, Arizona) Left to right: Smith, Fields, Lunde, Hanna Left to right: Morris, Graff-Radford, Parfitt, ShanderaOchsner, Chandler Back row, left to right: Caselli, Hoffman Snyder, Hurst, Young Front row: Cuc, Locke The HABIT Healthy Actions to Benefit Independence and ThinkingTM clinical program provides the basis for a robust program of clinical research. This research is aimed at improving patient-centered services for patients and families confronting mild cognitive impairment and risk of developing dementia. This is a true ‘One Mayo’ multi-disciplinary program operating cooperatively and nearly identically across all three Mayo sites. HABIT’s clinical, research, and education activities involve a team of four neuropsychologists, three certified yoga specialists, two dementia education specialists, two masters therapists, psychometrists, and 6 34 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY GRANTS NR012419-02 A Multicenter Rehabilitation Intervention for Amnestic Mild Cognitive Impairment PIs: Chandler, MC. and Locke, D.E.C.: 05/01/2010 – 07/31/2014, National Institute of Nursing Research. CER-1306 01897-1 Comparative Effectiveness of Behavioral Interventions to Prevent or Delay Dementia, PI Smith, GE. 07/01/2014 – 06/30/2017 Patient Centered Outcomes Research Institute. K12 HD065987-01 (Building Interdisciplinary Research Careers in Women’s Health K Scholar, J Fields, PI: Rebecca S. Bahn, MD) 01/03/2011 – 01/18/2013 NIH/NICHD Philanthropic Funding from the Ralph C. Wilson Foundation. KEY PUBLICATIONS Bondi MW, Smith GE. Mild cognitive impairment: a concept and diagnostic entity in need of input from neuropsychology. J Int Neuropsychol Soc. 2014 Feb; 20(2):129-34. Epub 2014 Feb 04. PMID:24490866. DOI:10.1017/S1355617714000010. Greenaway MC, Duncan NL, Smith GE. The memory support system for mild cognitive impairment: randomized trial of a cognitive rehabilitation intervention. Int J Geriatr Psychiatry. 2013 Apr; 28(4):402-9. Epub 2012 Jun 07. PMID:22678947. DOI:10.1002/ gps.3838. Fields, JA & Smith, GE, (2014). Behavioral Interventions to Prevent or Delay Dementia. National Academy of Neuropsychology Bulletin, 28:26-29. Locke, D.E.C., Chandler Greenaway, M, Duncan, NL et al. (in press). A patient centered analysis of enrollment and retention in a randomized behavioral trial of two cognitive rehabilitation interventions in Mild Cognitive Impairment. The Journal of Prevention of Alzheimer’s Disease. Smith, GE & Bondi, MW (2013). Mild Cognitive Impairment and Dementia: Definitions, Diagnosis, and Treatment. New York: Oxford University Press. Yutis M, Castro M, Bailey K, Gonzelz-Barrios P, Fields J, Lunde A., Hanna S and Smith G. (in press). Procedural Memory Differences in Patients with Mild Cognitive Impairment (MCI) and Mild Dementia due to Alzheimer’s Disease. The Clinical Neuropsychologist. INVITED PRESENTATIONS Gonzalez P, Castro M, Hanna S, Lunde A, Fields J, Locke DEC, & Smith G. (2014). Prioritization of treatment outcomes by caregivers of patients with mild cognitive impairment. Poster presentation at the 42nd Annual Meeting of the International Neuropsychological Society. February 12-15, 2014. Seattle, WA. Greenaway, M.C., Locke, D.E., Fields, J., & Smith, G.E. “Behavioral Interventions in Mild Cognitive Impairment.” American Academy of Clinical Neuropsychology annual meeting, Chicago, IL, 2013, June. Greenaway, M.C. “Mild Cognitive Impairment: Treatment after Diagnosis.” National Academy of Neuropsychology annual meeting, Nashville, TN, 2012, November. Locke, D.E.C., Fields, J.A., Cuc. A., Chandler Greenaway, M. et al. “A Multicomponent Intervention for Mild Cognitive Impairment Improves Mood and Cognition in Patients and Caregivers.” Poster presentation at the Arizona Alzheimer’s Consortium Research Symposium, Phoenix, AZ, 2014, June. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 35 MEDICAL DISE ASES INTERFACE WITH PSYCHIATRY & PSYCHOLOGY a licensed clinical social worker that serve as cognitive interventionists. Across the nation, individuals and families confronting mild cognitive impairment can access an innovative 10-day wellness and memory training program that has been shown in preliminary studies to improve overall quality of life and reduce caregiver burden. In 2014 the HABIT team concluded an NIH-funded project entitled “A Multicenter Rehabilitation Intervention for Amnestic Mild Cognitive Impairment”. By demonstrating that individuals with MCI and their care partners can be enrolled into a behavioral intervention program, stay in the program, and adhere to the rehabilitation methods taught, this pilot study helps to show the feasibility of this intervention. Additionally, this study allowed our team to refine delivery of a memory compensation intervention strategy as a formal compensatory program for memory loss in amnestic MCI. These preliminary findings helped our team successfully compete for Patient Centered Outcomes Research Institute (PCORI) funding of a large study entitled “Comparative Effectiveness of Behavioral Interventions to Prevent or Delay Dementia: A Study of HABIT”. This 3-year grant will enable a 3-site Mayo Clinic study examining which outcomes of the HABIT program are most important to which patients, and which of the five components of the HABIT program most impact those outcomes. This will enable Mayo to ensure future versions of the program most efficiently meet individual patient goals. The HABIT (Healthy Actions to Benefit Independence and ThinkingTM) Clinical Research Program continued Locke DEC, Hoffman Snyder C, Cuc AV, Fields JA, Smith GE, Chandler Greenaway M. (2013). Enrollment and retention data from a multi-site randomized rehabilitation intervention trial for individuals with amnestic Mild Cognitive Impairment. Oral platform and poster presentation at the Annual Conference of the Arizona Alzheimer’s Consortium. May 3, 2013. Phoenix, AZ. Smith, G.E., Fields, J., Chandler Greenaway, M.C., & Locke, D.E. “Behavioral Interventions to Prevent or Delay Dementia.” International Neuropsychological Society annual meeting, Seattle, WA, 2014, February. 6 36 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY MEDICAL DISE ASES INTERFACE WITH PSYCHIATRY & PSYCHOLOGY Obesity, Bariatric Surgery, and Eating Disorders Programs INVESTIGATORS Matthew M. Clark, Ph.D., ABPP, L.P., Karen B. Grothe, Ph.D., ABPP, L.P., Bridget K. Biggs, Ph.D., L.P., ABPP, Leslie A. Sim, Ph.D., L.P., ABPP, Karen M. Graszer, MA, LP, Sarah A. Kalsy, MA, LP, (Rochester, Minnesota), and Gretchen E. Ames, Ph.D., ABPP (Jacksonville, Florida) Back row, left to right: Rodgers, Clark, Biggs, Graszer Front, left to right: Sim, Grothe, Kalsy Ames This multidisciplinary research team is involved in several clinical projects and National Institutes of Health–funded clinical trials that examine the influence of psychological functioning and neurobiology on obesity and eating disorders and their treatment, conducted at the Rochester, Minnesota, and Jacksonville, Florida, sites of Mayo Clinic. Current adult investigations focus on primary care–based obesity treatment, and the impact of behavioral interventions, prevalence of food addiction, and response to treatment of chronic pain in bariatric surgery patients. Pediatric studies focus on understanding adolescents’ preferences for social support for development of a healthy lifestyle and the effect of training children and their parents in stress management and mindful eating based on body mass index and cardiovascular risk markers. Eating disorders research focuses on the use of functional magnetic resonance imaging to understand the neurobiological aspects of anorexia and bulimia nervosa. Additional studies examine the role of family functioning in adolescent eating disorders and explore whether athletes with eating disorders differ from non-athletes. The application of nonexercise activity thermogenesis to anorexia nervosa represents a novel method to understand and monitor weight regulation. Through our investigations, we hope to improve long-term treatment outcomes for persons with eating disorders and obesity. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 37 GRANTS National Heart, Lung, and Blood: Healthy Immigrant Families R01): Working Together to Move More and to Eat Well. Funding period: 12/2011 – 11/2016; Co-Investigator. Clark. National Institute of Diabetes and Digestive and Kidney Diseases (R01): Pharmacogenomics of Gastric Function and Weight in Obesity. Funding period: 09/2004 – 09/2015; PI: Camilleri (Division of Gastroenterology and Hepatology). National Institute of Diabetes and Digestive and Kidney Diseases (R01): Adjustable Gastric Banding and its Effects on Postprandial Glucose Metabolism Independent of Weight Loss. Funding period: 07/2010 – 06/2014; PI: Vella (Division of Endocrinology). National Institute of Heart, Lung and Blood (RO1): Healthy Immigrant Families: Working Together to Move More and To Eat Well. Funding period: 12/2011 – 11/2016. PI: Wieland (Primary Care Medicine) Enteromedics: ReCharge: A Prospective, Randomized, Blinded, Parallel-Group, Multicenter Trial to Evaluate the Safety and Efficacy of the Maestro RC2 System in Treating Obesity. Funding period: 05/2011 – 10/2016; PI: Que (Department of Surgery). Orexigen: A Multicenter, Randomized, Double-Blind, PlaceboControlled Study Assessing the Occurrence of Major Adverse Cardiovascular Events (MACE) in Overweight and Obese Subjects With Cardiovascular Risk Factors Receiving Naltrexone SR/ Bupropion SR. Funding period: 08/2012 – 08/2016; PI: Ebbert (Department of Medicine). Health Disparities Pilot Project: A formative study of wellness programming at Boys and Girls Club Rochester. Funding period: 09/2012 – 08/2013. PI: Biggs. Mayo Clinic Department of Psychiatry & Psychology Small Grants Program: An evaluation of an online, family-based indicated prevention program for adolescent eating disorders. Funding period: 05/2012 – 05/2014; PI: Sim. KEY PUBLICATIONS Almandoz JP, Singh E, Howell LA, Grothe K, Vlazny DT, Smailovic A, Irving BA, Nelson RH, Miles JM. Spillover of Fatty Acids during Dietary Fat Storage in Type 2 Diabetes: Relationship to Body Fat Depots and Effects of Weight Loss. Diabetes. 2013 Jan 24. Grothe KB , Mundi MS, Himes SM, Sarr MG, Clark MM, Geske JR, Kalsy SA, Frye MA. Bipolar Disorder Symptoms in Patients Seeking Bariatric Surgery. Obes Surg. 2014 Apr 22. Miranda, WR, Batsis, JA, Sarr, MG, Collazo-Clavell, ML, Clark, MM, Somers, VK, Lopez-Jimenez, F. Impact of bariatric surgery on quality of life, functional capacity, and symptoms in patients with heart failure. Obesity Surgery, 2013, 23 (7), 1011-1015. Prasad, C, Batsis, JA, Lopez-Jimenez, F, Clark, MM, Somers, VK, Sarr, MG, Collazo-Clavell, ML. Risk perception of obesity and bariatric surgery in patients seeking treatment for obesity. European Journal of Preventive Cardiology, 2014, 21 (6), 692-703. 6 38 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY Topazian M, Camilleri M, Enders FT, Clain JE, Gleeson FC, Levy MJ, Rajan E, Nehra V, Dierkhising RA, Collazo-Clavell ML, Talley NJ, Clark MM. Gastric antral injections of botulinum toxin delay gastric emptying but do not reduce body weight. Clin Gastroenterol Hepatol. 2013 Feb; 11(2):145-150. PRESENTATIONS Grothe KB, Mundi MS, Himes SM, Sarr MG, Clark MM, Geske JR, Kalsy SA, Frye MA. Bipolar disorder symptoms in patients seeking bariatric surgery and their relationship to undergoing bariatric surgery. Obesity Week, Atlanta, GA, November 2013. Grothe KB, Moradkhani A, Swain JM, Graszer K, Jensen M, Clark MM. Impact of behavioral therapy on outcomes after bariatric surgery: A pilot study. Obesity Week, Atlanta, GA, November 2013. Mundi M, Grothe KB, Clark MM, Lorentz P, Collazo-Clavell M. Feasibility and Efficacy of Smartphone based education modules and Ecological momentary assessment for Bariatric Surgery. Obesity Week, Atlanta, GA, November 2013. NATIONAL LEADERSHIP ROLES Grothe KB, Editorial Board Member, Bariatric Times. Grothe KB, Director, The Obesity Society Bariatric Section Education Committee. Clark MM, Editorial Board Member, Eating Behaviors. Ames GE, Member, The Obesity Society Membership Committee. Ames GE, Practice Samples Reviewer, American Board of Professional Psychology. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 39 Sleep Medicine INVESTIGATORS R. Robert Auger, M.D. (Rochester, Minnesota), Lois E. Krahn, M.D. (Scottsdale, Arizona), and Paul A. Fredrickson, M.D., Siong-Chi Lin, M.D. (Jacksonville, Florida) Krahn, Auger Fredrickson, Lin Mayo Clinic Department of Psychiatry & Psychology has historically been featured prominently in the field of sleep medicine. The late Peter J. Hauri, PhD, LP (professor emeritus, Mayo Clinic in Rochester) founded the American Sleep Disorders Association, authored the internationally renowned self-care book “No More Sleepless Nights”, and was widely considered to be the world’s authority on insomnia. Dr. Fredrickson is past president of the American Academy of Sleep Medicine (AASM). Drs. Auger, Lin, and Krahn continue this trend of national visibility and scholarship. Dr. Krahn served as joint editor of an influential sleep medicine textbook, Sleep Medicine in Clinical Practice, the second edition of which was recently published. Her research interests include narcolepsy, sleep disorders in women, and the interplay of psychiatric disorders and sleep. She previously has received funding from the Narcolepsy Network. Dr. Lin is investigating genetic research involving patients with restless legs syndrome, which has resulted in many important publications. Dr. Auger has served and/or chaired various AASM task forces, which have resulted in prominent publications and associated practice parameters. He was previously a member of the AASM Research Committee and of the American Sleep Medicine Foundation Executive Board. He chaired the AASM Circadian Rhythms Membership Section and has directed and participated in numerous sleep medicine sessions at national meetings. His primary research interests reside in the realm of circadian-based interventions for the treatment of sleep disorders. 6 40 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY KEY PUBLICATIONS Phillips Corporation: Comparing Wavelengths of Light in Seasonal Affective Disorder (SAD): A Placebo-Controlled Trial of ShortDuration Exposure (“SAD goQuick”). Funding period: 01/2012 – 01/2013; PI: Auger. Auger RR, Varghese R, Silber MH, Slocumb NL. Total sleep time obtained from actigraphy versus sleep logs in an academic sleep center and impact on further sleep testing. Nat Sci Sleep 2013;5:12531. Dejesus-Hernandez M, Rayaprolu S, Soto-Ortolaza AI, Rutherford NJ, Heckman MG, Traynor S, Strongosky A, Graff-Radford N, Van Gerpen J, Uitti RJ, Shih JJ, Lin SC, Wszolek ZK, Rademakers R, Ross OA. Analysis of the C9orf72 repeat in Parkinson’s disease, essential tremor and restless legs syndrome. Parkinsonism Relat Disord. 2012 Oct 17. [Epub ahead of print] PMID:23084342. DOI:10.1016/j. parkreldis.2012.09.013. Stewart CA, Auger RR, Enders FT, Felmlee-Devine D, Smith GE. The effects of poor sleep quality on cognitive function of patients with cirrhosis. J Clin Sleep Med. 2014;10(1):21-6. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 41 MEDICAL DISE ASES INTERFACE WITH PSYCHIATRY & PSYCHOLOGY GRANT Transplant Psychiatry INVESTIGATORS Tamara J. Dolenc, M.D., Shawna L. Ehlers, Ph.D., Daniel K. Hall-Flavin, M.D., Sheila G. Jowsey-Gregoire, M.D., Victor M. Karpyak, M.D., Ph.D., Larissa L. Loukianova, M.D., Ph.D., Teresa A. Rummans, M.D., Terry D. Schneekloth, M.D. (Rochester, Minnesota), Steven C. Ames, Ph.D., Shehzad K. Niazi, M.D., Adriana R. Vasquez, M.D. (Jacksonville, Florida), Robert P. Bright, M.D., Kari A. Martin, M.D., Thomas K. Nelson, M.D. (Scottsdale, Arizona) From left to right: Hall-Flavin, Schneekloth, Jowsey-Gregoire, Karpyak Transplant Center Psychiatry and Psychology research efforts have focused on both pre-transplant assessment and post-transplant outcomes for solid organ and BMT patients. Members of our research team continue a multi-center study of outcomes in alcoholic liver transplant candidates and have published findings on liver transplantation in alcoholic patients with ≤ 6 months abstinence, an area of increasing investigation and discussion in liver transplantation. Mayo’s leadership role in the assessment of hand transplant patients and the development of a multi-center database for hand transplant candidates was supported by the Tarek E. Obaid Grant. Dr. JowseyGregoire, in collaboration with Martin Kumnig, Ph.D., Medical University of Innsbruck, was invited to present at the first ever Transplant Psychiatry Symposium on Hand Transplantation at the American Society of Reconstructive Transplantation. Dr. Jowsey is also collaborating with researchers at the University of Alabama, Washington University, and the University of Minnesota on the NIDDK funded RELIVE study of long-term outcomes in kidney donors. Dr. Ehlers continues her investigation of modifiable unhealthy lifestyle behaviors and behavioral intervention development for hematopoietic stem cell transplant patients. Drs. Schneekloth, Jowsey, Rummans, Niazi and Vasquez are pursuing a series of studies to assess the predictive role of the Psychosocial Assessment of Candidates for Transplantation scale in determination of transplantation outcomes for lung, heart, and liver transplantation patients. Other research initiatives include outcomes in pancreas and lung transplant for patients with psychiatric conditions, the role of health coaching and health literacy in transplantation, the impact of post-transplant smoking on alcohol relapse in liver transplantation, and liver transplant outcomes in patients with Bipolar Disorder. 6 42 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY Early Career Research Development Supplement Award: Behavioral Intervention Development for Hematopoietic Stem Cell Transplant Survivors. Funding period: 2011-2012; PI: Shawna Ehlers, PhD. Tarek E. Obaid Award for Research in Vascularized Composite Transplantation: Development of a Psychosocial Assessment Tool for Reconstructive Hand Transplantation. Funding period: 20112012; PI: Sheila Jowsey, MD; Co-Investigators: Martin Kumnig, PhD, Medical University of Innsbruck, Schneekloth, Rummans, Kremers, Hatem. KEY PUBLICATIONS Cuellar-Barboza AB, Frye MA, Grothe K, Prieto ML, Schneekloth TD, Loukianova LL, Hall-Flavin DK, Clark MM, Karpyak VM, Miller JD, Abulseoud OA. Change in consumption patterns for treatment-seeking patients with alcohol use disorder post bariatric surgery. J Psychosom Res 2014 in press. Ehlers SL, Bronars CA, Patten CA, Brockman T, Hughes C, Decker PA, Cerhan JR, Hogan W, Dispenzieri A, Ansell S, Ebbert J, Gastineau D. Accuracy of self-reported tobacco use status among hematopoietic SCT patients. Bone Marrow Tranplant. 2014 Jul; 49(7):961-5. Epub 2014 Apr 14. PMID: 24732958. DOI: 10.1038/ bmt.2014.70. Jowsey SG, Cutshall SM, Colligan RC, Stevens SR, Kremers WK, Vasquez AR, Edwards BS, Daly RC, McGregor CG. Seligman’s theory of attributional style: optimism, pessimism, and quality of life after heart transplant. Prog Transplant. 2012 Mar; 22(1):49-55. Rivera MN, Jowsey S, Alsina AE, Torres EA. Factors contributing to health disparities in liver transplantation in a hispanic population. P R Health Sci J. 2012; 31(4):199-204. Romanowicz M, Ehlers SL, Walker D, Decker P, Rundell J, Shinozaki G, Litzow M, Hogan W, Mrazek D, Black J. Testing a diathesis-stress model: Potential genetic risk factors for development of distress in context of acute leukemia diagnosis and transplant. Psychosomatics. In press. Schneekloth TD, Jowsey SG, Biernacka JM, Burton MC, Vasquez AR, Bergquist T, Drews MS, Gores GJ. Pretransplant psychiatric and substance use comorbidity in patients with cholangiocarcinoma who received a liver transplant. Psychosomatics. 2012 Mar-Apr; 53(2):116-22. Solberg Nes, Ehlers SL, Patten CA, Gastineau DA. Self-regulatory fatigue in hematologic malignancies: impact on quality of life, coping, and adherence to medical recommendations. INT J Behav Med. 2013 Mar; 20(1):13-21. PMID: 21928059. DOI:10.1007/s12529011-9194-1. Solberg Nes, Ehlers SL, Patten CA, Gastineau DA. Self-regulatory fatigue, quality of life, health behaviors, and coping in patients with hematologic malignancies. Ann Behav Med. 2014 Dec; 48(3):411-23. PMID:24802991. DOI:10.1007/s12160-014-9621-z. Yost KJ, Eton DT, Sinicrope PS, Thompson CA, Rosenstein LJ, Allmer C, Maurer MJ, Slager SL, Ehlers SL, Link BK, Cerhan JR (In press). The FACT-G is valid for monitoring HRQOL in nonHodgkin lymphoma patients. Leukemia and Lymphoma. Kumnig M, Jowsey SG, Rumpold G, Weissenbacher A, Hautz T, Engelhardt TO, Brandacher G, Gabl M, Ninkovic M, Rieger M, Zelger B, Zelger B, Blauth M, Margreiter R, Pierer G, Pratschke J, Schneeberger S. The psychological assessment of candidates for reconstructive hand transplantation. Transpl Int. 2012 May; 25(5):573-85. Epub 2012 Mar 26. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 43 MEDICAL DISE ASES INTERFACE WITH PSYCHIATRY & PSYCHOLOGY GRANTS Integrated Behavioral Health Research INVESTIGATORS Kurt B. Angstman, M.D., Ramona S. DeJesus, M.D., Cesar A. Gonzalez, Ph.D., David J. Katzelnick, M.D., Gabrielle J. Melin, M.D., Victor M. Montori, M.D., Thomas G. Salter, M.D., Craig N. Sawchuk, Ph.D., Mary A. Severson, Ph.D., Nilay D. Shah, Ph.D., Nathan D. Shippee, Ph.D., Kristin J. Somers, M.D., Kristin S. Vickers Douglas, Ph.D., Mark D. Williams, M.D. Back row, left to right: Sawchuk, Katzelnick, Mattson, Salter, Zarling, Bobo Front row, left to right: DeJesus, Williams, Brennan The primary care and behavioral health interface is a rich environment for research. This multidisciplinary team of investigators is from a variety of disciplines and specialities. They have been investigating the implementation of evidence based quality improvement projects for several prevalent mental health conditions presenting in the primary care setting. There are ongoing investigations examining a multidisciplinary treatment team approach for adult depression care (DIAMOND) with several projects led by Drs. Kurt Angstman and Ramona DeJesus on outcomes and qualitative research on care management led by Dr. Kristin Vickers Douglas. A project examining Emergency Department utilization is led by Dr. Gabrielle Melin and research on patients presenting with unexplained medical symptoms is led by Dr. Kristin Somers. The Coordinated Anxiety Learning and Management (CALM) is an innovative model for the provision of evidence-based psychotherapy in primary care for adults with anxiety disorders. Initial outcomes show results for patients with generalized anxiety disorder are robust and clinically significant. This research team has also created an adolescent depression treatment program called Early Management and Evidence-Based Recognition of Adolescents Living With Depression (EMERALD). Both of these patient care models are very well received by patients and primary care providers. These efforts received additional support with a substantial 3-year grant with the Center for Medicare and Medicaid studies as a part of a multisite implementation of a model of care coordination for patients co-morbid for Diabetes, Cardiovascular Disease, and Depression (COMPASS). Our research team is busy starting up implementation of this project in the Mayo Clinic Health System at six primary care sites around our state. 6 44 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY GRANTS Agency for Healthcare Research and Quality (R18): Translation of Comparative Effectiveness of Depression Medications into Practice. Funding period: 09/2010 – 08/2013; PI: Montori; co-investigator: Williams. Center for Medicare and Medicaid Services (CMS): Care Management of Mental, Physical, and Substance use Syndromes (COMPASS). Funding period: 6/2012- 7/2015. PI: Williams and Katzelnick. KEY PUBLICATIONS Chung H, Duffy FF, Katzelnick DJ, Williams MD, Trivedi MH, Rae DS, Regier DA. Sustaining practice change one year after completion of the national depression management leadership initiative. Psychiatr Serv. 2013 Jul 1; 64(7):703-6. PMID:23821170. DOI:10.1176/ appi.ps.201200227. Clark MM, Bradley KL, Jenkins SM, Mettler EA, Larson BG, Preston HR, Liesinger JT, Werneburg BL, Hagen PT, Harris AM, Riley BA, Olsen KD, Vickers Douglas KS. The Effectiveness of Wellness Coaching for Improving Quality of Life. Mayo Clin Proc. 2014 Jul 31. PMID:25107468. DOI:10.1016/j.mayocp.2014.04.028. DeJesus RS, Howell L, Williams M, Hathaway J, Vickers KS. Collaborative care management effectively promotes selfmanagement: patient evaluation of care management for depression in primary care. Postgrad Med. 2014 Mar; 126(2):141-6. PMID:24685978. DOI:10.3810/pgm.2014.03.2750. Meunier MR, Angstman KB, MacLaughlin KL, Oberhelman SS, Rohrer JE, Katzelnick DJ, Matthews MR. Impact of symptom remission on outpatient visits in depressed primary care patients treated with collaborative care management and usual care. Popul Health Manag. 2014 June; 17(3):180-4. Epub 2014 Feb 04. PMID:24495212. DOI: 10.1089/pop.2013.0057. Parsaik AK, Singh B, Hassan Murad M, Singh K, Mascarenhas SS, Williams MD, Lapid MI, Richardson JW, West CP, Rummans TA. Statins use and risk of depression: a systematic review and metaanalysis. J Affect Disord. 2014 May; 160:62-7. Epub 2013 Dec 17. PMID:24370264. DOI:10.1016/j.jad.2013.11.026. Shippee ND, Rosen BH, Angstman KB, Fuentes ME, DeJesus RS, Bruce SM, Williams MD. Baseline screening tools as indicators for symptom outcomes and health services utilization in a collaborative care model for depression in primary care: a practicebased observational study. Gen Hosp Psychiatry. 2014 Nov-Dec; 36(6):563-9. Epub 2014 Jul 10. PMID:25179215. DOI:10.1016/j. genhosppsych.2014.06.014. Shippee ND, Shah ND, Angstman KB, Dejesus RS, Wilkinson JM, Bruce SM, Williams MD. Impact of collaborative care for depression on clinical, functional, and work outcomes: a practice-based evaluation. J Ambul Care Manage. 2013 Jan; 36(1):13-23. Vickers KS, Ridgeway JL, Hathaway JC, Egginton JS, Kaderlik AB, Katzelnick DJ. Integration of mental health resources in a primary care setting leads to increased provider satisfaction and patient access. Gen Hosp Psychiatry. 2013 Sep-Oct; 35(5):461-7. Epub 2013 Jul 30. PMID:23910217. DOI:10.1016/j.genhosppsych.2013.06.011. Hoberg AA, Vickers KS, Ericksen J, Bauer G, Kung S, Stone R, Williams M, Moore MJ, Frye MA. Feasibility evaluation of an interpersonal and social rhythm therapy group delivery model. Arch Psychiatr Nurs. 2013 Dec; 27(6):271-7. Epub 2013 Sep 1 2P.MID:24238006. PMCID:4020708. DOI:10.1016/j.apnu.2013.08.002. Howell LA, Clark SM, Dierkhising RA, Thomas RJ, Vickers KS. Predicting patient expectations about survival following cardiac events. Am J Health Behav. 2013 Nov; 37(6):800-6. PMID:24001629. DOI:10.5993/AJHB.37.6.9. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 45 SCIENCE OF HE ALTH CARE DELIVERY Cook DJ, Moradkhani A, Douglas KS, Prinsen SK, Fischer EN, Schroeder DR. Patient Education Self-Management During Surgical Recovery: Combining Mobile (iPad) and a Content Management System. Telemed J E Health. 2014 Apr; 20(4):312-7. Epub 2014 Jan 20 .PMID:24443928. PMCID:3968874. DOI:10.1089/tmj.2013.0219. McPherson K, Bronars C, Patten C, Decker P, Hughes C, Levine J, Vickers-Douglas K, Williams M, Ussher M. Understanding word preference for description of exercise interventions as a means for enhancing recruitment and acceptability of exercise treatment among adults treated for depression. Mental Health and Physical Activity. 2014; 7(2):73-7. Christi A. Patten, Ph.D. Dr. Patten, Professor of Psychology and a Career Scientist, directs the Behavioral Health Research Program located in the Mayo Clinic Cancer Center. Her research team focuses on developing novel, theory-based behavioral interventions for tobacco cessation targeting Alaska Natives, pregnant women, adolescents, smokers with psychiatric comorbidity and the social network of smokers. The research team recently completed a large effectiveness trial funded by ClearWay Minnesota and enrolling 704 nonsmokers (i.e., support persons). The research team also has a commitment to reducing cancer health disparities among Native Americans. During the past 13 years, the team has established a successful partnership with the Alaska Native community. Community research priorities are focused on reducing tobacco use among pregnant women and youth. This work currently is funded through several NIH grants. Dr. Patten is also nearing completion of a study that developed and is now evaluating a family-based intervention to promote mammography screening among Navajo women. GRANTS National Cancer Institute: Family Cancer Literacy to Promote Mammography Screening Among Navajo Women. Funding period: 09/2010 – 09/2014; PI: Patten. National Cancer Institute: Biomarker Feedback to Motivate Tobacco Cessation in Pregnant Alaska Native Women. Funding period: 09/2010 – 08/2015; PI: Patten. ClearWay Minnesota: Support Person Effectiveness Study to Promote Smoker Utilization of the QUITPLAN Helpline. Funding period: 01/2011 – 12/2014; PI: Patten. National Cancer Institute: Community Intervention to Reduce Tobacco Use among Pregnant Alaska Native Women. Funding period: 07/2013-04/2018; PI: Patten. Hooten WM, Townsend CO, Hays JT, Ebnet KL, Gauvin TR, Gehin JM, Laures HJ, Patten CA , Warner DO. A cognitive behavioral smoking abstinence intervention for adults with chronic pain: a randomized controlled pilot trial. Addict Behav. 2014 Mar; 39(3):593-9. Epub 2013 Nov 21. PMID:24333035. DOI:10.1016/j.addbeh.2013.11.010. McPherson K, Bronars C, Patten C , Decker P, Hughes C, Levine J, VickersDouglas K, Williams M, Ussher M. Understanding word preference for description of exercise interventions as a means for enhancing recruitment and acceptability of exercise treatment among adults treated for depression. Mental Health and Physical Activity. 2014; 7(2):73-7. Patten CA , Fadahunsi O, Hanza MM, Smith CA, Decker PA, Boyer R, Ellsworth L, Brockman TA, Hughes CA, Bronars CA, Offord KP. Tobacco cessation treatment for Alaska native adolescents: group randomized pilot trial. Nicotine Tob Res. 2014 Jun; 16(6):836-45. Epub 2014 Feb 14. PMCID:4015099. DOI:10.1093/ntr/ntu004. National Heart, Lung, and Blood Institute: Healthy Immigrant Families: Working Together to Move More and to Eat Well. Funding period: 12/201111/2016; PI: Sia. Radecki Breitkopf C, Asiedu GB, Egginton J, Sinicrope P, Opyrchal SM, Howell LA, Patten C , Boardman L. An investigation of the colorectal cancer experience and receptivity to family-based cancer prevention programs. Support Care Cancer. 2014 Sep; 22(9):2517-25. Epub 2014 Apr 13. PMID:24728620. DOI:10.1007/s00520-014-2245-9. KEY PUBLICATIONS Solberg Nes L, Ehlers SL, Patten CA , Gastineau DA. Self-Regulatory Fatigue, Quality of Life, Health Behaviors, and Coping in Patients with Hematologic Malignancies. Ann Behav Med. 2014 May 07. PMID:24802991. DOI:10.1007/s12160-014-9621-z. Biggs BK, Lebow J, Smith CM, Harper KL, Patten CA , Sim LA, Kumar S. Adolescents’ Preferences for Social Support for Healthful Eating and Physical Activity. J Dev Behav Pediatr. 2014 Sep 16. PMID:25229275. DOI:10.1097/DBP.0000000000000094. Ehlers SL, Bronars CA, Patten CA , Brockman T, Hughes C, Decker PA, Cerhan JR, Hogan W, Dispenzieri A, Ansell S, Ebbert J, Gastineau D. Accuracy of self-reported tobacco use status among hematopoietic SCT patients. Bone Marrow Transplant. 2014 Jul; 49(7):961-5. Epub 2014 Apr 14. PMID:24732958. DOI:10.1038/bmt.2014.70. Graves KD, Sinicrope PS, Esplen MJ, Peterson SK, Patten CA , Lowery J, Sinicrope FA, Nigon SK, Borgen J, Gorin SS, Keogh LA, Lindor NM. Communication of genetic test results to family and health-care providers following disclosure of research results. Genet Med. 2014; 16(4):294-301. 6 46 Tiedje K, Wieland ML, Meiers SJ, Mohamed AA, Formea CM, Ridgeway JL, Asiedu GB, Boyum G, Weis JA, Nigon JA, Patten CA , Sia IG. A focus group study of healthy eating knowledge, practices, and barriers among adult and adolescent immigrants and refugees in the United States. Int J Behav Nutr Phys Act. 2014; 11:63. Epub 2014 May 16. PMCID:4030459. DOI:10.1186/1479-5868-11-63. AWARDS AND LEADERSHIP ROLES Christi A. Patten, Ph.D., Chair, National Institutes of Health; Risk, Prevention and Intervention in the Addictions (RPIA) Study Section, 07/01/2014-present. Christi A. Patten, Ph.D., Assistant Editor, Addiction. DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY CAREER DE VELOPMENT Marin Veldic, M.D. Dr. Veldic is a Senior Associate Consultant who has a research interest in the molecular pathophysiology of mood disorders. His career research objective is to integrate clinical phenotyping, genetic/epigenetic screening, and neuroimaging for individualized diagnosis and treatment of people living with mental illness. Dr. Veldic’s current clinical research focus is on the translational progression from his bench research on epigenetic regulation of the neuronal gene expression in mood disorders and psychosis. The main project that Dr. Veldic is currently working on is an epigenetic study aimed at identifying potential clinical and molecular differences between bipolar disorder patients with and without comorbid binge eating disorder, nicotine dependence, and alcohol use disorder. Specifically, his study will evaluate how the expression of glutamate system genes is regulated in different phenotypical subtypes of bipolar disorder. Results of that study can potentially open new avenues for individualized treatment algorithms and enhance treatment outcomes for patients diagnosed with bipolar disorders. Dr. Veldic conducts his research under the mentorships of Drs. Mark Frye and Doo-Sup Choi. GRANTS PUBLISHED ABSTRACTS Mayo Clinic Center for Individualized Medicine Career Development Award: Epigenetic DNA Methylation in Patients with Bipolar Disorder with and Without Comorbid Addiction. Funding period: 07/2012-07/2015. PI: Veldic. Cuellar Barboza AB, Abulseoud OA, Prieto ML, Biernacka JM, Kung S, Alarcon RD, Veldic M, Moore MJ, Frye MA: Serotonin Transporter Gene Polymorphism, Alcohol Use Disorders Association in Refractor Mood Disorder Patients. American Psychiatric Association Annual Meeting, 2013. Mayo Clinic Department of Psychiatry and Psychology Small Grants Program: Epigenetic Regulation of the Expression of Metabotropic Glutamate Receptors (mGluR2 and mGluR3) in Patients with Bipolar Disorder with and without Comorbid Alcohol Use Disorder. Funding period: 07/2014-07/2015. Co-PI: Veldic; CoPI: Blacker. KEY PUBLICATIONS Biernacka JM, McElroy SL, Crow S, Sharp A, Benitez J, Veldic M, Kung S, Cunningham JM, Post RM, Mrazek D, Frye MA. Pharmacogenomics of antidepressant induced mania: A review and meta-analysis of the serotonin transporter gene (5HTTLPR) association. Journal of Affective Disorders. 2011; 136(1-2): e21-9. Guidotti A, Dong E, Gavin DP, Veldic M, Zhao W, Bhaumik DK, Pandey SC, Grayson DR. DNA-methylation/demethylation network expression in psychotic patients with a history of alcohol abuse. Alcoholism: Clinical and Experimental Research. 2013; 37(3):417-24. Ringler JA, Kang N, Choi Y, Choi D, Veldic M. Epigenetic regulation of eaat2 (slc1a2) in bipolar disorder patients. Bipolar Disord. 2014 Mar; 16:72. Veldic M, McElroy SL, Biernacka JM, Chauhan M, Ayers-Ringler JR, Cuellar Barbosa AB, Prieto ML, Fuentes Salgado ME, Geske JR, Choi YB, Seymour, LR, Choi DS, Frye MA. Clinical phenotypes of bipolar disorder with differential addiction: potential role of epigenetic regulation. Biol Psychiatry. 2014 May 1; 75(9):43S. HONORS American College of Neuropsychopharmacology Travel Award, 2013. Weinshilboum Prize for Pharmacogenomics, 2012. District Branch Representative, American Psychiatric Association Advocacy Day, 2009. Tueting P, Davis JM, Veldic M, Pibiri F, Kadriu B, Guidotti A, Costa E. L-methionine decreases dendritic spine density in mouse frontal cortex. Neuroreport. 2010; 21 (8): 543-8. Veldic M, Choi DS, Port JD, Biernacka JM, Sharp A, Meng P, Chia K, Mrazek D, Frye MA. Elevated Anterior Cingulate Glutamate Associated with SLC1A2 polymorphisms in patients with depression. Biological Psychiatry. 2010; 67 (9S): 130S. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 47 Stacey J. Winham, Ph.D. Dr. Winham is an Assistant Professor of Biostatistics and a Collaborative Scientist in the Department of Health Sciences Research. She collaborates with numerous investigators in our Department and is a statistical geneticist with specialization in the development of novel statistical tools for high-dimensional genetic data analysis. As an NIH ‘Building Interdisciplinary Research Careers in Women’s Health’ (BIRCWH) scholar. Dr. Winham has a specific interest in integrating the X chromosome into genetic data analysis and studying sex-specific genetic effects in psychiatric diseases. Dr. Winham investigates genetic factors underlying alcohol dependence and related traits (such as craving, depression, and relapse), as well as sex-specific differences. Dr. Winham also examines genetic risk factors for bipolar disorder and related subtypes (such as patients with comorbid obesity), focusing on genetic risk factors that may differ in men and women. GRANTS Fraternal Order of the Eagles Cancer Research Fund: Characterization of X chromosome inactivation patterns in ovarian cancer. Funding period: 10/01/2014-09/30/2015. PI: Winham. NIH Office of Research in Women’s Health: Application of Systems Biology to Study Genetic Factors Underlying Complex Traits in Women’s Health. Funding period: 07/01/2013-07/01/2015. PI: Bahn. KEY PUBLICATIONS Karpyak VM, Winham SJ, Biernacka JM, Cunningham JM, Lewis KA, Geske JR, Colby CL, Abulseoud OA, Hall-Flavin DK, Loukianova LL, Schneekloth TD, Frye MA, Heit JA, Mrazek DA. Association of GATA4 sequence variation with alcohol dependence. Addict Biol. 2014 Mar; 19(2):312-5. Epub 2012 Aug 02. PMID:22862823. PMCID:3504631. DOI:10.1111/j.13691600.2012.00482.x. McElroy SL, Crow S, Biernacka JM, Winham S , Geske J, Cuellar Barboza AB, Prieto ML, Chauhan M, Seymour LR, Mori N, Frye MA. Clinical phenotype of bipolar disorder with comorbid binge eating disorder. J Affect Disord. 2013 Sep 25; 150(3):981-6. Epub 2013 Jun 03. PMID:23742827. DOI:10.1016/j.jad.2013.05.024. Preuss UW, Winham SJ , Biernacka JM, Geske JR, Bakalkin G, Koller G, Zill P, Soyka M, Karpyak VM. PDYN rs2281285 variant association with drinking to avoid emotional or somatic discomfort. PLoS One. 2013; 8(11):e78688. Epub 2013 Nov 06. PMID:24223163. PMCID:3819371. DOI:10.1371/journal. pone.0078688. 6 48 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY Winham S. Applications of multifactor dimensionality reduction to genome-wide data using the R package ‘MDR’. Methods Mol Biol. 2013; 1019:479-98. PMID:23756907. DOI:10.1007/978- 1-62703-4470_23. Winham SJ, Biernacka JM. Gene-environment interactions in genome-wide association studies: current approaches and new directions. J Child Psychol Psychiatry. 2013 Oct; 54(10):1120-34. Epub 2013 Jun 28. PMID:23808649. PMCID:3829379. DOI:10.1111/ jcpp.12114. Winham SJ, Cuellar-Barboza AB, McElroy SL, Oliveros A, Crow S, Colby CL, Choi DS, Chauhan M, Frye MA, Biernacka JM. Bipolar disorder with comorbid binge eating history: a genomewide association study implicates APOB. J Affect Disord. 2014 Aug; 165:151-8. Epub 2014 Apr 19. PMID:24882193. DOI:10.1016/j. jad.2014.04.026. Winham SJ, Cuellar-Barboza AB, Oliveros A, McElroy SL, Crow S, Colby C, Choi DS, Chauhan M, Frye M, Biernacka JM. Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2. Mol Psychiatry. 2014 Sep; 19(9):1010-6. Epub 2013 Dec 10. PMID:24322204. DOI:10.1038/mp.2013.159. Winham SJ, Freimuth RR, Biernacka JM. A Weighted Random Forests Approach to Improve Predictive Performance. Stat Anal Data Min. 2013 Dec 1; 6(6):496-505. PMID:24501613. PMCID:3912194. DOI:10.1002/sam.11196. CAREER DE VELOPMENT Paul E. Croarkin, D.O., M.S.C.S. Dr. Croarkin is a child and adolescent psychiatrist whose research efforts focus on understanding the physiology, treatment, and classification of mood disorders in children and adolescents. This work includes clinical trials in child and adolescent mood disorders; long-term studies of the safety of selective serotonin reuptake inhibitors in youth, studies of novel therapeutics, such as repetitive transcranial magnetic stimulation (rTMS); and neurophysiological studies of the GABA and glutamate neurotransmitter systems. Dr. Croarkin has served as a co-investigator for collaborative trials in child and adolescent depression and as primary investigator for a study funded by Brain and Behavior Research Foundation that involved novel single and paired-pulse transcranial magnetic stimulation (TMS) measures of GABA and glutamate functioning in children and adolescents with major depressive disorder. His ongoing research will examine glutamate neurotransmission in adolescent psychiatric disorders with concurrent TMS paradigms and magnetic resonance spectroscopy. GRANTS Mayo Clinic: Glutamate Probes in Adolescent Depression. Funding period: 05/21/2012 – 05/20/2014. PI: Croarkin. NIMH Mentored Patient-Oriented Research Career Development Award 1K23MH10026-01A1 Glutamate Probes in Adolescent Depression (PI: Croarkin, Mentor: Frye) 02/2013-01/2018. Brain and Behavior Research Foundation, NARSAD Young Investigator Award. Glutamatergic Neurotransmission in Youth at Risk for Bipolar Disorder (PI: Croarkin, Mentor: Frye) 07/201307/2015. KEY PUBLICATIONS Croarkin PE, Nakonezny PA, Husain MM, Port JD, Melton T, Kennard BD, Emslie GJ, Kozel FA, Daskalakis ZJ. Evidence for pretreatment LICI deficits among depressed children and adolescents with nonresponse to fluoxetine. Brain Stimul 2014;7(2):243-51. Noda Y, Daskalakis ZN, Downar J, Croarkin PE, Fitzgerald PB, Blumberger. DM. Magnetic Seizure Therapy in an Adolescent with Refractory Bipolar Depression: A Case Report. Neuropsychiatric Disease and Treatment, 2014 (in press) Wall CA, Croarkin PE, McClintock SM, Murphy LL, Bandel LA, Sim LA, Sampson SM. Neurocognitive effects of repetitive transcranial magnetic stimulation in adolescents with major depressive disorder. Front Psychiatry 2013;12(4):165. Wehry AM, McNamara RK, Adler CM, Eliassen JC, Croarkin P, Cerullo MA, DelBello MP, Strawn JR. Neurostructural impact of co-occuring anxiety in pediatric patients with major depressive disorder: A voxel-based morphometry study. J Affect Disord. 2014 Sep 16;171C:54-59. doi: 10.1016/j.jad.2014.09.004. [Epub ahead of print] AWARDS, HONORS, OFFICES, ETC. National Network of Depression Centers Croarkin PE, Nakonezny PA, Lewis CP, Zaccariello MJ, Huxsahl JE, Husain MM, Kennard BD, Emslie GJ, Daskalakis ZJ. Developmental aspects of cortical excitability and inhibition in depressed and healthy youth: an exploratory study. Front Hum Neurosci 2014;8:669. Member of Biomarker Task Force Croarkin PE, Thomas MA, Port JD, Baruth JM, Choi DS, Abulseoud OA, Frye MA. N-acetylaspartate normalization in bipolar depression after lamotrigine treatment. Bipolar Disorders 2014 (in press). Frontiers in Neuropsychiatric Imaging and Stimulation (Editorial Board-Guest Associate Editor) Member of Child and Adolescent Psychiatry Task Force Scientific Peer Advisory and Review Services Division of the American Institute of Biological Sciences (Ad hoc reviewer) Co-Chair of Annual Meeting, Clinical Society of TMS 2014-2015 Kozel FA, Croarkin PE, Mapes KS. A non-epileptiform event in the course of rTMS: a case for close physician monitoring. Brain Stimul 2013;6(6):970-2. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 49 Maria I. Lapid, M.D. Dr. Lapid is a geriatric psychiatrist with the American Board of Psychiatry and Neurology (ABPN) board certifications in Geriatric Psychiatry and Hospice and Palliative medicine. Her clinical practice includes leading multidisciplinary treatment teams in taking care of geriatric patients with medical and psychiatric comorbidities in the inpatient, outpatient, and longterm care settings; as an attending physician and faculty on the inpatient and outpatient palliative consultation services; and she is also one of the associate medical directors of the Mayo Clinic Hospice Program. She is the founding program director of the Mayo Clinic Geriatric Psychiatry Fellowship. Her clinical research involves quality-oflife (QOL) issues of patients in geriatric, oncologic, or palliative care and their caregivers. She is leading a Psycho-Oncology research study on internet-based interventions for cancer caregivers to improve their quality of life and prevent burnout. MENTORS Teresa A. Rummans, M.D. and Matthew M. Clark, Ph.D. GRANTS Linse Bock Foundation: Improving Quality of Life of Cancer Caregivers. Funding period: 01/2012 – 12/2016; PI; Lapid; Co-PIs: Rummans, Clark. KEY PUBLICATIONS Burton MC, Warren M, Cha S, Stevens M, Blommer M, Lawson D, Kung S, Lapid MI. Identifying Psychiatric Patients who may Benefit from a Palliative Care Approach. Palliative Medicine 2014; (in press). Chock MM, Lapid MI , Atherton PJ, Kung S, Sloan JA, Richardson JW, Clark MM, Rummans TA. Impact of a structured multidisciplinary intervention on quality of life of older adults with advanced cancer. Int Psychogeriatr. 2013 Dec; 25(12):2077-86. Epub 2013 Sep 04. PMID:24001635. DOI:10.1017/S1041610213001452. Hu C, Kung S, Rummans TA, Clark MM, Lapid MI . Reducing caregiver stress with internet-based interventions: a systematic review of open-label and randomized controlled trials. J Am Med Inform Assoc. 2014 Aug 14. PMID:25125686. DOI:10.1136/ amiajnl-2014-002817. Lapid MI , Atherton PJ, Kung S, Cheville AL, McNiven M, Sloan JA, Clark MM, Rummans TA. Does gender influence outcomes from a multidisciplinary intervention for quality of life designed for patients with advanced cancer? Support Care Cancer. 2013 Sep; 21(9):2485-90. Epub 2013 Apr 23. PMID:23609927. DOI:10.1007/s00520-013-1825-4. McKean AJ, Lapid MI , Geske JR, Kung S. The Importance of Code Status Discussions in the Psychiatric Hospital: Results of a Single Site Survey of Psychiatrists. Acad Psychiatry. 2014 Aug 21. PMID:25142252. DOI:10.1007/s40596-014-0218-4. Piderman KM, Johnson ME, Frost MH, Atherton PJ, Satele DV, Clark MM, Lapid MI , Sloan JA, Rummans TA. Spiritual quality of life in advanced cancer patients receiving radiation therapy. Psychooncology. 2014 Feb; 23(2):216-21. Epub 2013 Sep 09. PMID:24019196. DOI:10.1002/pon.3390. Clark MM, Atherton PJ, Lapid MI , Rausch SM, Frost MH, Cheville AL, Hanson JM, Garces YI, Brown PD, Sloan JA, Richardson JW, Piderman KM, Rummans TA. Caregivers of patients with cancer fatigue: a high level of symptom burden. Am J Hosp Palliat Care. 2014 Mar; 31(2):121-5. Epub 2013 Feb 21. PMID:23434836. DOI:10.1177/1049909113479153. Piderman KM, Radecki Breitkopf C, Jenkins SM, Lovejoy LA, Dulohery YM, Marek DV, Durland HL, Head DL, Swanson SW, Hogg JT, Evans JL, Jorgenson SE, Bunkowski LJ, Jones KL, Euerle TT, Kwete GM, Miller KA, Morris JR, Yoder TJ, Lapid MI , Jatoi A. The Feasibility and Educational Value of Hear My Voice, a Chaplain-Led Spiritual Life Review Process for Patients with Brain Cancers and Progressive Neurologic Conditions. J Cancer Educ. 2014 Jun 22. [Epub ahead of print] PMID:24952300. DOI:10.1007/s13187-014-0686-y. Clark MM, Rummans TA, Atherton PJ, Cheville AL, Johnson ME, Frost MH, Miller JJ, Sloan JA, Graszer KM, Haas JG, Hanson JM, Garces YI, Piderman KM, Lapid MI , Netzel PJ, Richardson JW, Brown PD. Randomized controlled trial of maintaining quality of life during radiotherapy for advanced cancer. Cancer. 2013 Feb 15; 119(4):880-7. Epub 2012 Aug 28. PMID:22930253. DOI:10.1002/ cncr.27776. Shahi V, Lapid MI , Kung S, Atherton PJ, Sloan JA, Clark MM, Rummans TA. Do age and quality of life of patients with cancer influence quality of life of the caregiver? J Geriatr Oncol. 2014 Jul; 5(3):331-6. Epub 2014 Apr 14. PMID:24726867. DOI:10.1016/j. jgo.2014.03.003. Feely MA, Havyer RD, Lapid MI , Swetz KM. Management of endof-life care and of difficult behaviors associated with borderline personality disorder. J Pain Symptom Manage. 2013 May; 45(5):934-8. Epub 2012 Aug 24. PMID:22921178. DOI:10.1016/j. jpainsymman.2012.04.004. 6 50 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY Warren MB, Lapid MI, McKean AJ, Cha S, Steven M, Brekke FM, Hegard TL, Kung S, Burton MC. Code Status in Psychiatric and Medical Inpatients. Journal of Clinical Psychiatry 2014; (in press). 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 51 6 52 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY Research Fellows and Residents Left to right: Nassan, Bronars, Hitschfeld Carrie A. Bronars, Ph.D. Christi A. Patten, Ph.D., Mentor Dr. Carrie Bronars’ research interests include health disparities, with an emphasis in tobacco control, smoking cessation among psychiatric populations, behavioral medicine and chronic disease management, and mental health treatment in Primary Care settings. She has published 22 peer-reviewed journal articles and presented 33 abstracts at national conferences. Currently, Dr. Bronars is working on several projects exploring potential physiological mechanisms related to mood, smoking cessation, and immunity among depressed women smokers. Mario J. Hitschfeld, M.D. Terry D. Schneekloth, M.D., Mentor Dr. Hitschfeld completed his psychiatry residency at the University of Valparaiso in Chile in 2012. His two year research fellowship at the Mayo Clinic is focused on addiction and transplant psychiatry. In addiction psychiatry, he is completing a study about the impact of gender and smoking status on alcohol craving and alcohol abstinence and another on the screening of substance misuse among adolescent psychiatric inpatients. He is the recipient of a Travel Award to attend the 2014 American Academy of Addiction Psychiatry Annual Meeting. In transplant psychiatry, he received a Department Small Grant to complete three studies about the pre-transplant psychosocial predictors of post-transplant outcomes among lung, heart and liver transplant recipients. Malik M. Nassan, MBBS Mark A. Frye, M.D., Mentor Dr. Nassan, a recent medical graduate, has been always interested in translating genetic research from the bench to the bedside. While in medical school, he did research training in genetics at Harvard, Brigham, and Women’s Hospital, as well as at King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. His work as a fellow focuses on discovering the underpinning mechanism of bipolar disorder. He is currently investigating the association between brain-derived neurotrophic factor (BDNF) gene and early onset bipolar disorder. His project’s findings have been presented in national meetings and an original manuscript is currently under review. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 53 Resident Researchers C. Jacquetta Blacker, B.M.B.Ch., PGY-3 Resident Marin Veldic, M.D., Mentor Left to right: Lee, Lewis, Blacker, Reyes, Takala Dr. Blacker has a background in surgery and prior research experience with in vitro studies of nitric oxide production in models of sepsis. As a psychiatry resident, she has an interest in epigenetic modifications causing long term alterations in genetic transcription. She is currently working with the Molecular Pharmacology laboratory on a study of epigenetic regulation of glutamate receptor expression in bipolar patients with and without comorbid alcohol use disorder. Folabo Y. Dare, DO, PGY-3 Resident Kathryn M. Schak, M.D. and Keith G. Rasmussen, M.D., Co-Mentors Dr. Dare’s primary research interests include topics related to forensic psychiatry, including court-approved ECT and chemical dependency treatment, as well as court-ordered medication administration. She has presented her work on the tolerability and efficacy of court-approved ECT at the American Academy of Psychiatry and the Law Annual Meeting. Her paper on court-approved ECT has recently been accepted for publication in the Journal of ECT. Dr. Dare’s current project focuses on the long-term postdischarge outcomes of patients for whom a court order for the administration of neuroleptic medication was required. Jung In (Kristin) Lee, M.D., PGY-4 Resident Simon Kung, M.D., Mentor Dr. Lee has an interest in geriatric psychiatry and her primary research focus is on dementia and neurodegenerative disorders. She is currently studying trends in the treatment of behavioral and psychiatric symptoms of dementia. She has presented her data regarding antipsychotic use in dementia patients in an inpatient setting at the American Association of Geriatric Psychiatry annual meeting. Recent research interests include deep brain stimulation for psychiatric applications. Charles P. Lewis, MD., Child & Adolescent Psychiatry Fellow Paul E. Croarkin, DO., Mentor Dr. Lewis has previous research experience in the study of child and adolescent mood disorders and adult substance use disorders utilizing neuroimaging techniques. His primary current research interests are the neurobiological correlates of mood disorders and suicidal behavior in child and adolescent populations and the development of biological markers for these conditions. His current projects focus on investigating potential biomarkers of depression severity and suicidal risk in adolescents utilizing transcranial magnetic stimulation (TMS) neurophysiologic techniques and proton magnetic resonance spectroscopy (MRS) to examine potential dysfunction of excitatory and inhibitory neurotransmitter systems. 6 54 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY Asfia Qaadir, D.O., Child & Adolescent Psychiatry Fellow Paul E. Croarkin, D.O., Mentor Dr. Qaadir has a prior research background in the study of childhood ADHD and candidate genes utilizing pharmacogenomics. She has presented a poster on the neuropsychiatric manifestations of SREAT (Steroid responsive encephalopathy associated with autoimmune thyroiditis) at the American Association of Geriatric Psychiatry meeting. Dr. Qaadir also participated in a symposium at the American Academy of Child and Adolescent Psychiatry annual meeting focusing on the anatomy and physiology of GABA (gamma-aminobutyric acid) as it pertains to dysregulation in adolescent depression. She has explored models of inpatient adolescent female group psychotherapy. Currently evolving research interest is in exploring patterns of mental health-seeking behaviors among Rochester’s Muslim community. Maria M. Reyes, M.D. PGY-4 Resident Terry D. Schneekloth, M.D., Mentor Dr. Reyes has a broad research background that includes grand rounds presentations on sleep disturbances in substance dependent populations and parental attitudes regarding school-based immunizations. She has participated in several presentations at national meetings including the Pediatric Academic Society, American Medical Association, American Association for Geriatric Psychiatry and the American Psychiatric Association. Dr. Reyes has co-authored two prior scientific publications, “Parental Attitudes about Influenza Immunization and School-Based Immunization for School-Aged Children,” and “Identifying the Human Research Subject in Cluster Randomized Controlled Trials”. She is currently studying the clinical utility of ADHD testing instruments in adults with alcoholism. She is also conducting research on gender differences in the psychiatric comorbidity among adults with both alcoholism and ADHD. Both studies are being reviewed for publication in peer reviewed journals. Christopher R. Takala, D.O., Child & Adolescent Psychiatry Fellow Brian A. Palmer, MD and Leslie A. Sim, Ph.D., L.P., Co-Mentors Dr. Takala’s primary research interests have been broad during his tenure. He is involved in a project that aims to provide greater exposure to child-adolescent psychiatry and complement existing curricula at various medical schools throughout the nation by using video-teleconferencing technology. The goal is to ultimately help address the chronic child psychiatry workforce shortage. A separate project focuses on parental perceptions of mental illness in adolescents admitted to inpatient psychiatry. Findings to date have led to a presentation at a national meeting, as well as a manuscript currently submitted for publication. In addition, a separate project assesses concurrent use of ECT with bupropion. Findings will be presented at a national conference and a manuscript will be submitted for publication. He has publications in several journals including: General Hospital Psychiatry, Academic Psychiatry, and the Annals of Pharmacotherapy. He has reviewed articles for the Journal of Psychiatry: Open Access and Journal of Pharmacy Technology. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 55 Medical Psychology Fellows Alissa M. Butts, Ph.D. – Clinical Neuropsychology Fellow Mary M. Machulda, Ph.D., L.P. and Jane H. Cerhan, Ph.D., L.P., Co-Mentors Dr. Butts is broadly interested in the neurocognitive correlates of neurodegenerative and neurologic diseases. As part of the Speech/Language Neurodegenerative Disorders research group, she has Back row, left to right: Craner, Green, Butts, Junghans-Rutelonis, Early been investigating the utility of neuropsychological Front row, left to right: McTate, Koball, Morrison, Krishnan testing and potential biomarkers associated with advanced neuroimaging techniques (e.g., structural MRI, DTI, and FDG PET) in differentiating between various neurodegenerative disorders that present with primary language disturbance. She is also involved in exploring the neurocognitive correlates of various brain tumors. Under the direction of Dr. Jane Cerhan and her collaborators, Dr. Butts is examining the neurocognitive function of individuals with incidental meningioma, which they have found during the workup as a healthy control through the Mayo Clinic Study of Aging. Julia R. Craner, Ph.D. – Clinical Health Psychology Fellow Kristin Vickers Douglas, Ph.D. and Craig N. Sawchuk, Ph.D., Co-Mentors Dr. Craner is a first year Clinical Psychology Fellow and has a research background in the study of psychological responses to physiological changes, particularly with regard to women’s health issues. Her current interests are developing and evaluating programs to integrate psychological services in medical settings in order to better address these mind-body relationships, and she is involved in several projects within Integrated Behavioral Health (IBH). Martha C. Early, Ph.D. – Clinical Child Psychology Fellow Karen E. Weiss, Ph.D., L.P., Bridget K. Biggs, Ph.D., L.P., Stephen P. Whiteside, Ph.D., L.P., and Leslie A. Sim, Ph.D., L.P., Mentors Dr. Early’s primary research interest is in emotion regulation in children as it relates to psychopathology and chronic medical conditions. As a part of her doctoral dissertation Dr. Early focused on regulation of positive emotion and developed a self-report measure of positive emotion regulation for children and adolescents. She has presented data collected from this project in a symposium for the Association for Behavioral Cognitive Therapy annual meeting as well as numerous posters at national and international conferences. She presented a poster at the National Conference on Child Clinical and Adolescent Psychology examining emotion regulation and family functioning in psychiatrically hospitalized adolescents. Her current research includes examining emotion regulation in adolescents with chronic pain as well as peer competence in youth with Anxiety Disorders. 6 56 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY Cassie M. Green, Psy.D. – Clinical Pediatric Neuropsychology Fellow Tanya M. Brown, Ph.D., L.P., Mentor Dr. Green is researching neuropsychological outcomes in a pediatric brain tumor population. She is specifically interested in identifying demographic and treatment variables that may place children with brain tumors at higher risk for poor cognitive, behavioral, and psychosocial outcomes. Dr. Green is also conducting research based out of the outpatient Brain Rehabilitation Clinic with Dr. Thomas Bergquist. They are interested in describing patient and injury characteristics of a traumatic brain injury sample upon admission to the clinic, as well as identifying relationships among injury severity, demographics, psychosocial functioning, and overall outcome. Ashley N. Junghans-Rutelonis, Ph.D. – Clinical Child Psychology Fellow Karen E. Weiss, Ph.D., Mentor Dr. Junghans-Rutelonis has a research background in the study of child, young adult, and family adjustment to chronic illness. Her interests include the transactional nature of child and parental adjustment and the manner in which cognitions shape understanding of and functioning with illness. She has previously assessed psychological well-being and cognitive affective variables in individuals with allergies, asthma, juvenile rheumatic disease, Turner’s syndrome and Huntington’s Disease. She is currently involved in projects focused on child outcome variables, including functional disability, in pediatric chronic pain and Postural Orthostatic Tachycardia Syndrome. Afton M. Koball, Ph.D., L.P. – Clinical Health Psychology Fellow Karen B. Grothe, Ph.D., L.P., Mentor Dr. Koball’s primary research interests are focused broadly in obesity. Particularly, she has been involved in several published investigations of novel behavioral weight management interventions, psychological correlates of weight loss, and the impact of weight bias and stigma on weight and psychological distress. Currently, she is working on a study examining food addiction in bariatric-surgery seeking patients. She has presented this work at Obesity Week, the joint annual meeting of the American Society for Metabolic and Bariatric Surgery and The Obesity Society, in November 2014. Dr. Koball also has been involved in multidisciplinary research projects, including with the Mayo Clinic Healthy Weight Initiative and the Neuropsychiatric Research Institute in Fargo, ND. Kamini Krishnan, Ph.D. – Clinical Neuropsychology Fellow Mary M. Machulda, Ph.D., L.P., Mentor Dr. Krishnan’s research interests include investigating the relationship between neuroimaging findings and neurocognitive function. Currently, she is involved in a preliminary project categorizing patients diagnosed with logopenic aphasia based on hypometabolism patterns observed on their PET scans. Future investigations will examine whether identified regions with hypometabolism correlate with cognitive deficits. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 57 Emily A. McTate, Ph.D., L.P. – Clinical Child Psychology Fellow Karen E. Weiss, Ph.D., L.P., and Jarrod M. Leffler, Ph.D., L.P., Co-Mentors Dr. McTate’s primary research interests include projects that bridge the world of research and clinical practice. She is involved in several research projects, which include a multi-site study evaluating a problem-solving intervention for use with parents of adolescents with chronic pain and a study evaluating psychological symptoms as they relate to functional impairment in adolescents with postural orthostatic tachycardia syndrome. Additionally, she has presented posters at the International Symposium on the Autonomic Nervous System, the National Conference in Clinical Child and Adolescent Psychology, the International Conference on Child and Adolescent Psychopathology, and has abstracts submitted to Society of Pediatric Psychology Annual Conference and accepted at the Association of Psychologists in Academic Health Centers 7th National Conference. Eleshia J. Morrison, Ph.D., L.P. – Clinical Health Psychology Fellow Shawna L. Ehlers, Ph.D., L.P.; Matthew M. Clark, Ph.D., L.P., Co-Mentors Dr. Morrison’s research examines the biopsychosocial aspects of oncology. Her interests cover the spectrum of the cancer experience across different phases of cancer survivorship, treatment modalities, disease types, and psychosocial correlates. Current projects include the examination of employment status as a marker of adjustment post-stem cell transplantation for hematologic cancers; and psychological distress, physical symptom burden, and quality of life in lung and breast cancer survivors. 6 58 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY The Research Psychometrics Resource Jane H. Cerhan, Ph.D., L.P., Shelly J. Kotyk Sellnow, Kimberly J. Bailey, and Blair N. Cronk From left to right: Bailey, Cerhan, Cronk, Kotyk Sellnow The Research Psychometrics Resource (RPR) provides psychological and cognitive testing for researchers throughout the institution. The RPR matches investigators across Mayo Clinic seeking validated psychometric questionnaires and testing in collaboration with a psychologist investigator who can assist in proper test selection, study design, and data interpretation. RPR psychometrists have expertise in the administration of psychological testing, have research training and backgrounds, and they provide test procurement, scheduling, test-administration, quality control and certain data management services under the auspices of the Psychological Assessment Laboratory in the Department of Psychiatry and Psychology. Established in 2000, the RPR has facilitated collaborations between the Department of Psychiatry and Psychology and numerous other departments including Cardiology, Neurology, Anesthesiology, Radiation Oncology, Gynecology, Physical Medicine and Rehabilitation, Internal Medicine, and Surgery. Example protocols have included: • Characterization of Silent Cerebral Lesions in Patients Undergoing Left Heart Ablation for Ventricular Arrhythmia and Atrial Fibrillation. PI – Asirvatham • A Longitudinal Study of Alterations in Cognitive Function and Brain Metabolites among Women Receiving Chemotherapy for Primary Breast Cancer. PI -- Kholi • Effects of Estrogen Replacement on Atherosclerosis Progression in Recently Menopausal Women: The Kronos Early Estrogen Prevention Study. • Neurodevelopment of Children Exposed to Anesthesia: A Population Based Assessment. PI – Warner Department of Psychiatry and Psychology Research Team Jilian Foxen, Lisa Seymour, Michelle Skime, Christine Hughes, Shari Sutor, Lorelei Bandel, Almila Erol, Scott Feeder, Judy Gebhard, Lee Gunderson, Barb Hall, Allison Hanson, Deanna Hofschulte, Tara Johnson, Angel McPhee, Malik Nassan , Katie O’Connor, Blair Price, Jose Rico, Katrina Schafer, and Cynthia Stoppel. Third row, left to right: Price, Johnson, Gunderson, Feeder, Second row, left to right: Hofschulte, Nassan, O’Connor, Schaefer, Sutor, Skime, Hanson First row, left to right: Mc Phee, Bandel, Hall, Erol, Stoppel The primary role of the departmental research team is to serve as facilitators and offer support services that encourage research activities for any staff member who has an interest in engaging in research. The scope of expertise includes administration of pre/post grant submission related activities, clinical trials research as well as basic science research. In 2014, the research structure in our department underwent reorganization. As a result, Jilian Foxen has joined the department to lead the research team as Senior Program Coordinator- Research Operations. A core group of talented allied health professionals support the administrative function of the department’s research and include Lisa Seymour, Program Coordinator; Barb Hall, Protocol Specialist III; and Lori Solmonson, Research Secretary. Over the past decade these individuals have supported research related activities for the department and their expertise in research finance, protocol development, grant submission, manuscript submission, and preparations for national and international scientific educational sessions serve as a key resource for any provider pursuing research activities. To support the department’s growth of research activities related to clinical trials, Michelle Skime, Senior Clinical Research Coordinator, leads a team of well-trained associate and clinical research coordinators. On average ten dedicated clinical coordinators support over 80 active clinical research protocols throughout the department including, but not limited to the Pain Rehabilitation Program, Addiction Center, and Mood Clinic. A second group dedicated to Community Health Education Outreach is the Behavioral Health Research Program led by Dr. Christi Patten. Christine Hughes is the Program Coordinator. Their research focuses on developing behavioral interventions for tobacco cessation and reducing cancer health disparities. Their current research targets Alaska Natives, Native Americans, pregnant women, smokers with psychiatric comorbidity and the social network of smokers. 6 60 DEPARTMENT OF PSYCHIATRY AND PSYCHOLOGY In addition to clinical studies, a basic science laboratory led by Dr. Tye and Shari Sutor, Principle Research Technologist, focuses on supporting the molecular and small animal research protocols of neurologic translational research. Two research technicians and a wealth of research facilities are located on the second floor of the Generose Building alongside the inpatient and outpatient Psychiatry and Psychology Department. The laboratory is equipped for protein work (western blotting and ELISA), molecular biology (PCR, RT-PCR, SNP analysis, and gene expression), immunohistochemistry of tissues, cell culture and immortalization of cells, and also the processing of clinical samples. The animal research area is located at the downtown campus in the Stabile Building. In the animal facilities we are looking at pharmacotherapies, deep brain stimulation and the combinations of the two, as well as analyzing multiple behavioral tests for efficacy of the treatments. These facilities are available to support clinicians engaged in translational neuro science. 507.266.5100 | WWW.MAYOCLINIC.ORG/PSYCHIATRY-RST 61 MC0710-11rev0115