Transcript
Sophisticated Life Science Research Instrumentation
TSE SpectroPan For Sophisticated Real-time Particle Analysis
www.TSE-Systems.com
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Contents ■■ Introduction 3 ■■ Working Principle
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■■ Application 6 ■■ Software 7 ■■ Specifications 8 ■■ Ordering Information ■■ Partial List of Users
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Introduction Based on single particle measurement implemented via laser technology the Aerosol Analyzer SpectroPan (Spectrum Particle Analyzer) provides all features necessary for sophisticated approaches in aerosol research and aerosol application.
Advantages The most important features are: ■■ Real-time
Especially the high resolution for different particle classes, the realtime characteristic and the comfortable software package contribute to a system surely meeting your requirements.
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measurement of particle size distribution and aerosol concentration Minimized influence of particle material by using near forward scattering High sensivity due to laser diode technology Usefull for all aerosol concentrations due to a minimized measuring volume User friendly Windows Software Recommended for many applications (especially inhalation studies) Rugged design with optimized dimensions
Measuring display SpectroPan software
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Working Principle The optical measuring setup of SpectroPan uses near forward scattering (due to physically proved advantages) and is especially designed for optical single particle counting in highconcentration aerosols. The technical solution is based on the reduction of the sample volume to a high degree.
The advantages of forming the measuring zone this way are: ■■ the
For this reason both the aerosol stream and illuminating laser beam are one-dimensional focussed and rectangularly superimposed with the detection plan (limited by a slit stop in front of the photo detector).
A laser diode serves as light source. The 128 pulse height classification as a measure of particle size (multi channel pulse height analysis) is the basis for the determination of particle size distribution using the calibration function integrated.
The figure below shows schematically the measuring volume, implemented by an intelligent combination of illuminating, detecting and aerosol plane.
The entire measuring range covers particle sizes from 0.3 to 40 μm. It has been proved that only at number concentrations higher than 104 particle/cm3 losses in the counting rate are caused due to coincidence.
high grade optical particle isolation and particle detection performed in a region which provides the maximum amount of light intensity
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Measuring volume
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Below is a schematic overview of all the essential components. Scattered light is collected by the “light gathering optics”, while the “original“ light beam is removed by a “light trap”.
A coating air stream surrounding the aerosol saves the instrument and reduces maintenance acitivities effectively.
Optical measuring arrangement
First measuring result is a count frequency distribution. All other values are calculated.
Using geometric equations or parameters (e.g. density of the substance) entered by the user.
Count frequency distribution of a 519 nm PSL aerosol used for calibration – channel 31 shows the data for particles of 0.519 mm www.TSE-Systems.com
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Application Due to it´s high technical standard SpectroPan provides all features necessary to meet the requirements of a wide range of approaches.
Application fields … of the aerosol analyzer SpectroPan: ■■ General
The hardware adaptation to an existing piece of equipment can be performed easily. Often a probe fixed into the system of interest is all you need.
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Some applications must take several precautions into account. Please ask our experts how to perform e.g. isokinetic sampling or how to prevent artefacts generated by your system during the sampling procedure.
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measurement of particle size e.g. for aerosol research Inhalation studies Air quality analysis (pollution) Reference measurements performed with calibration aerosols Validation of aerosol generators (e.g. spray cans, MDIs, dust generators and nozzles) Filter testing and characterization
Polynomial calibration function
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Software Based on our experience we developed the user friendly data acquisition and particle sizer control software.
General features provided ■■ Calculation
Simple software operations as well as the possibility to edit calibration data by an experienced user are provided.
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The software offers calculation and realtime display of particle size distribution (number, surface, volume, mass) as either a graph or table.
Application fields module module (measurement duration, number of measurements, remarks) Experiment module (procedure according to the setup, presentation of calculated data in realtime, raw data storage)
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and realtime display of aerosol concentration Up to 128 pulse height classes Summarizing of different measuring ranges Statistical functions Data comparison Software support to other Windows applications (e.g. data export) System test
■■ Calibration ■■ Setup
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■■ Analysis
and export module
Below a result of an aerosol produced for the validation of an inhalation equipment is shown. Due to the preseparation of larger particles the aerosol meets in a perfect manner the requirements important for inhalation studies.
Distribution curve of an analysis
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Specifications Particle size range
0.3 to 40 μm
Number concentration
< 104 particles/cm³
Pulse height classes
User defined (max. 128)
Flow rate
User defined
Laser diode
30 mW / 660 nm / > 20.000 h
Interface
Special interface
AD adapter
110...230 V AC / 50-60 Hz / 12 V DC / 4.2 A
Calibrated by PSL aerosols (particle size standards) and DEHS (Di-Ethylhexyl-Sebacate) droplet aerosols
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Ordering Information Cat. No.
Description
700800-PA-100
Real-time particle analyzer (laser diode technology) Range: 0.3 to 40 μm, up to 104 particles/ cm³, incl. software package for process control
700800-PA-100-SP
Spare Part Set for SpectroPan 700800-PA-100, 700800-PA-110 or 700800-PA-120
700800-PA-110
SpectroPan with software module for Online Control/ Monitoring System Daco Real-time particle analyzer (laser diode technology), range: 0.3 to 40 μm, up to 104 particles/ cm³, incl. software package for process control
700800-PA-120
SpectroPan with Calibration Certificate and software module for Online Control/ Monitoring System Daco Real-time particle analyzer (laser diode technology), range: 0.3 to 40 μm, up to 104 particles/ cm³, incl. software package for process control Calibration Certificate from an independent institute for calibration of particle size measurement via an alternative method
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Partial List of Users ■■ Almirall
Prodesfarma, S.A., St. Feliu de Llobregat Barcelona, Spain
■■ IVAX
Drug Research Institute Ltd., Budapest, Hungary
■■ KT&G ■■ Astra
Zeneca R&D Charnwood, Loughborough, Leicestershire, Great Britain
Central Research Institute, Yuseong-gu, Daejeon, South Korea
■■ LAB ■■ Bioagri
Pharma, Planaltina, DF, Brazil
■■ Boehringer
Ingelheim Pharma GmbH & Co. KG, Biberach,
Germany
International Research Center Hungary Ltd., Veszprem, Hungary
■■ Lovelace
Respiratory Research Institute, Albuquerque, NM,
USA
■■ Charles
River Laboratories, Tranent, Edinburgh, Great Britain
■■ Mahidol
University, Bangkok, Thailand
■■ Pulmatrix ■■ Chiesi
Inc., Lexington, MA, USA
Farmaceutici S.p.A., Parma, Italy ■■ Schering-Plough
■■ CIEMAT,
Madrid, Spain ■■ The
■■ Dow
Corning Corporation, Midland, MI, USA
■■ DSO
National Laboratories, Singapore, Singapore
Dow Chemical Company, Midland, MI, USA
■■ UFZ,
Leipzig, Germany
■■ Universidad ■■ Elbion
de Salamanca, Salamanca, Spain
AG, Radebeul / Dresden, Germany
■■ GSF-Forschungszentum
Neuherberg, Germany
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Research Institute, Kenilworth, NJ, USA
■■ University
of California, Irvine, CA, USA
■■ University
of Minnesota, Minneapolis, MN, USA
für Umwelt & Gesundheit, GmbH,
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Product Overview This overview illustrates additional products which are supplied by TSE Systems. Detailed information concerning each of the items listed below can be found on our website, for any additional information please do not hesitate to contact us: ■■ Behavior
Conditioning, Activity & Exploration, Video Tracking, Mazes, Startle Response, Anxiety & Depression, Motor Function & Performance, Rotameter ■■ PhenoMaster
/ LabMaster Calorimetry, Drinking & Feeding & Body Weight, Home Cage Activity, Running Wheel
■■ NewBehavior
Products IntelliCage (cognitive screening for up to 16 mice living in a social group in a home cage environment), NeuroLogger (4 channels wireless EEG recording & activity)
■■ Kinematic
Analysis MotoRater (evaluation of locomotor functions using high-speed video tracking: Ladder / Walking / Wading / Swimming)
■■ Analgesia
Hot Plate, Tail Flick, Randall Selitto, Power Meter (Incapacitance Tester) ■■ Physiology
Blood Pressure Monitoring – invasive & non-invasive, Telemetry, Volume Meter, Bronchospasm Measuring, Animal Respirators, Anesthesia Equipment ■■ Inhalation
Head Nose Only, Whole Body and Cell Culture Exposure Units, Aerosol Generation & Conditioning, Cigarette Smoke Generators, Aerosol Analysis, Inhalation Software ■■ Stereotaxic
Instruments
■■ Isolated
Organs Organ Bath Systems, Langendorff and Working Heart Systems
■■ Microtomes
Krumdieck Tissue Slicer ■■ Pumps
& Infusion Syringe Pumps, Animal Infusion Systems
■■ Surgery
& Handling Operating Tables, Homeothermic Blankets, Temperature and ECG Pads
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Sophisticated Life Science Research Instrumentation
Service & Warranty TSE Systems offers additional modules to create a complete exposure system. Please find out more about:
■■ Head
Nose Only Exposure Units Modular, stackable structure for different size conditioning units. Available for animal sizes from mouse to dog with directed-flow principle
■■ Whole
Body Exposure Units Robust, user-friendly design for homogeneous test substance distribution. Different volumes available for variable animal sizes and test animal numbers
■■ Cell
Culture Exposure System Ideally suited system for screening tests with tissue, using Transwell® inserts of varying sizes. Extended viability of cultures by heating/humidification
■■ Nanoparticle
Analysis TSE System offers instrumentation to analyze nanoparticle size and concentration, such as Condensation Particle Counter or Differential Mobility Analyzer
TSE Systems offers a Two (2) Years ALLIN Premium Warranty with all new products, including: 24/7 technical hotline Remote maintenance and update function ■■ On-site visits upon necessity ■■ Free replacement parts ■■ ■■
After the expiry of the warranty period, TSE Systems offers comprehensive extensions of the warranty or economical maintenance and repair contracts to ensure the continued smooth running of your instruments. Please contact us for further details.
■■ Daco
Inhalation Software Control and recording software for inhalation systems with multi-control mode for system extension. Advanced safety and GLP compliance features
■■ Sensors
and Controllers TSE Systems supplies a number of environmental sensors and mass flow controllers specifically designed for each inhalation system
Specifications subject to change without notice Copyright © 2014 TSE Systems International Group - All rights reserved
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